Frontiers in Neuroscience | Neurodegeneration

Original Research

Published on 23 Jan 2026

MicroRNA profiling in post-mortem spinal cord of C9ORF72-related ALS patients reveals molecular pathways involved in motor neuron degeneration

in Neurodegeneration

Giorgia Farinazzo
Eleonora Giagnorio
Matteo Marcuzzo
Marco Cattaneo
Claudia Malacarne
Paola Cavalcante
Silvia Bonanno
Emanuela Maderna
Viviana Pensato
Cinzia Gellera

Frontiers in Neuroscience

doi 10.3389/fnins.2026.1741065

1,202 views

Original Research

Published on 22 Jan 2026

Comparative effect of vortioxetine and sertraline on clinical and inflammatory profile in Parkinson’s disease with comorbid depression

in Neurodegeneration

Marika Alborghetti
Camilla Moliterni
Edoardo Bianchini
Domiziana Rinaldi
Daniela Caissutti
Antonella Capozzi
Fabiana Giada Radicati
Antonella Moschillo
Martina Marino
Isabella Berardelli

Frontiers in Neuroscience

doi 10.3389/fnins.2026.1761550

1,181 views

Original Research

Published on 16 Jan 2026

Cerebral responses to famous face recognition as a potential functional biomarker of mild cognitive impairment

in Neurodegeneration

Michihiko Koeda
Yumiko Ikeda
Yoshiro Okubo
Amane Tateno

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1698395

879 views

Review

Published on 15 Jan 2026

The controversial role of nutraceuticals vs. drugs in proliferative retinopathies

in Neurodegeneration

Dario Rusciano
Paola Bagnoli

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1727089

809 views

Editorial

Published on 13 Jan 2026

Editorial: The role of glial cells in the pathophysiology and treatment of Alzheimer's disease

in Neurodegeneration

Simone M. Crivelli
Zainuddin Quadri
Daan van Kruining
Pilar Martinez-Martinez
Erhard Bieberich
Jean-Yves Chatton

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1749170

956 views

Original Research

Published on 13 Jan 2026

Glutathione metabolism as a key regulator of oxidative hippocampal injury in sepsis-associated encephalopathy: an integrated proteomics and metabolomics study

in Neurodegeneration

Yanning Li
Linan Wang
Teng Ma
Tao Peng
Lijuan Wang
Junyan Wang
Yunhong Li
Yin Wang

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1671955

968 views

Original Research

Published on 12 Jan 2026

Depression mediates motor dysfunction’s effect on sleep quality in ALS: a mediation analysis study

in Neurodegeneration

Yuchen Zhu
Gan Zhang
Hong Liu
Tielun Yin
Jiaying Zhang
Yanjing Yang
Linna Bai
Xiaoxuan Liu
Dongsheng Fan
Shan Ye

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1643367

580 views

Original Research

Published on 12 Jan 2026

Clinical characteristics and risk factors of depression in prodromal Parkinson’s disease

in Neurodegeneration

Jianxia Xu
Yali Wang
Yuqian Li
Hui Wang
Weiguo Liu

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1708805

736 views

Review

Published on 12 Jan 2026

Ferroptosis in Alzheimer’s disease: molecular mechanisms and advances in therapeutic strategies

in Neurodegeneration

Ze Zhou
Yiting Zhang
Siyi Liu
Haixia Tang
Lianhao Yang
Yanming Lu
Jiaobao Liao
Shuowei Zhang
Zukun Chen
Ling Yang

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1673315

1,435 views

Original Research

Published on 12 Jan 2026

Neuroprotective, eco-friendly iron oxide nanoparticles to alleviate Parkinson’s disease symptoms and improve nursing care

in Neurodegeneration

Shuangyan Chen
Ting Jiang

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1692707

546 views

Original Research

Published on 07 Jan 2026

P75NTR blockading inhibits Trem2+ M1 phenotype microglia activation and myelin damage following mild traumatic brain injury

in Neurodegeneration

Xu Li
Zhen Xu
Jing Fang
Hua-Dong Huang

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1641112

1,124 views

Review

Published on 06 Jan 2026

Tank-binding kinase 1 regulates inflammation and autophagy in glaucoma

in Neurodegeneration

Autumn B. Morgan
Denise M. Inman

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1735403

1,124 views

Original Research

Published on 05 Jan 2026

Superoxide dismutase is associated with cerebral small vessel disease burden and vascular mild cognitive impairment in elderly patients

in Neurodegeneration

Xiaohua Xie
Meixi Li
Tianyuan Guan
Zhenjie Teng
Jing Feng
Jing Xu
Qianqian Qi
Yining Xiao
Peiyuan Lv
Yanhong Dong

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1720400

783 views

Review

Published on 02 Jan 2026

Structure and function of the blood–brain barrier in perioperative neurocognitive disorders

in Neurodegeneration

Yipeng Su
Yiting Chen
Bingqi Zheng
Yiting Huang
Zhongxiao Liao
Xiaochun Zheng
Fei Gao

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1690354

1,525 views

Original Research

Accepted on 29 Dec 2025

A novel TGFβ1–Hs3st2–tau axis regulates tau pathology and reduces synaptic alterations in hippocampal neurons

in Neurodegeneration

Rafael Castillo-Negrete
Heloise Merrick
Sethupathiraj SELVARAJ
Minh Bao Huynh
Xavier LAFFRAY
Ajitha Thuraisamy
Martin Diener
Peter Jedlicka
Mohand Ouidir OUIDJA
Dulce PAPY-GARCIA

Frontiers in Neuroscience

490 views

Original Research

Accepted on 26 Dec 2025

Teneurin-2 and related proteins in reactive astrocytes after status epilepticus induction in adult rats

in Neurodegeneration

Gestter Willian Lattari Tessarin
David William Hogg
Alaide Gonçalves
Daniel Vieira Casatti
Vitória Morelli Savenhago
Bárbara Stéfani Silva da Costa
Viviam Barbuglio Del Priore
David A Lovejoy
José de Anchieta Castro Horta-Junior
Cláudio Aparecido Casatti

Frontiers in Neuroscience

240 views

Review

Published on 19 Dec 2025

Sigma receptors and mitochondria-associated ER membranes are converging therapeutic targets for Alzheimer’s disease

in Neurodegeneration

Madhura S. Lotlikar
Jacob C. Zellmer
Raja Bhattacharyya

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1733659

2,859 views

Systematic Review

Published on 17 Dec 2025

Effects of transcranial direct current stimulation on non-motor functions in individuals with Parkinson’s disease: a systematic review and meta-analysis

in Neurodegeneration

Qiyu Li
Hanmei Ye
Cheng Ye
Mi Huang

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1713623

1,666 views
1 citation

Original Research

Published on 16 Dec 2025

Sex differences in depression in Parkinson’s disease: cognitive dysfunction and female-specific associations

in Neurodegeneration

Huashuo Zhao
Yi Sun
Qiushuang Wang
Zixuan Zhao

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1704461

1,273 views

Review

Published on 15 Dec 2025

ER stress sensors at the ER-mitochondrial interface, controlling mitochondrial health in neurodegenerative diseases

in Neurodegeneration

Chaitanya Kunja
Vaishali Kumar
Pradeep Kodam
Chamundeshwari Devi Gopu
Shuvadeep Maity

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1665272

1,777 views

Original Research

Published on 08 Dec 2025

Modeling and validation in Parkinson’s disease patients with frailty

in Neurodegeneration

Guoyang Li
Guo Hong
Jing Huang
Wenli Zhang
Fengju Mao
Xiaoguang Luo

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1723707

1,220 views

Review

Published on 08 Dec 2025

Advancements in the application of brain-computer interfaces based on different paradigms in amyotrophic lateral sclerosis

in Neurodegeneration

Tong Li
Yuling Gao
Jiaqi Zhou
Yize Chen
Shengchao Zhang
Xiaoyang Gong
Yong Liu

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1658315

3,084 views
1 citation

Original Research

Published on 04 Dec 2025

Depletion of CD169+ border-associated macrophages induces Parkinson’s disease-like behavior

in Neurodegeneration

Takuto Ohki
Kai Kitamura
Katsuhiro Tokutake
Sota Saeki
Michiro Yamamoto
Masaki Takasu
Hitoshi Hirata

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1688394

1,408 views

Correction

Published on 04 Dec 2025

Correction: Network pharmacology analysis reveals neuroprotective effects of the Qin-Zhi-Zhu-Dan Formula in Alzheimer's disease

in Neurodegeneration

Wenxiu Xu
Beida Ren
Zehan Zhang
Congai Chen
Tian Xu
Shuling Liu
Chongyang Ma
Xueqian Wang
Qingguo Wang
Fafeng Cheng

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1752611

816 views