Frontiers in Neuroscience | Neurodegeneration

Original Research

Published on 23 May 2025

Bidirectional modulation of Alzheimer’s disease via gut microbiota: rescue by fecal transplantation from healthy donors and aggravation by colitis-associated dysbiosis

in Neurodegeneration

Chenglong Zhou
Xin Feng
Huina Liu
Ting Cai
Yihong Li
Huadong Fan

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1593854

4,142 views
2 citations

Original Research

Published on 21 May 2025

Expression and potential regulatory mechanism of cellular senescence-related genes in Alzheimer’s disease based on single-cell and bulk RNA datasets

in Neurodegeneration

Dujuan Sha
Jingxuan Zhang
Xu Fang
Xinyu Wang
Xuan He
Xin Shu

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1595847

5,846 views
4 citations

Original Research

Published on 20 May 2025

Differential retinal ganglion cell resilience to optic nerve injury across vertebrate species

in Neurodegeneration

Julie D. De Schutter
Anyi Zhang
Pieter-Jan Serneels
Lieve Moons
Luca Masin
Steven Bergmans

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1596464

4,371 views
3 citations

Original Research

Published on 14 May 2025

Improved dementia screening for elderly with low education in South Korea using the Cognitive Impairment Screening Test (CIST)

in Neurodegeneration

Kyung Wook Kang
Gilsoon Park
Hyunsoo Kim
Soo Hyun Cho
Seong-Min Choi
Kang-Ho Choi
Hak-Loh Lee
Gwangsoon Shon
Byeong C. Kim
Hosung Kim

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1599019

3,318 views
3 citations

Review

Published on 12 May 2025

Biological engineering approaches for modulating the pathological microenvironment and promoting axonal regeneration after spinal cord injury

in Neurodegeneration

Xiaohong Chen
Rong Huang
Zhe Yang
Jun Zhang
Yanling Yang
Feng Gao
Minli Liu
Shengjun Zhang

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1574763

3,751 views
1 citation

Review

Published on 12 May 2025

The key role of the ferroptosis mechanism in neurological diseases and prospects for targeted therapy

in Neurodegeneration

Chenyu Xie
Nan Wu
Jiaojiao Guo
Liangliang Ma
Congcong Zhang

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1591417

3,527 views
4 citations

Review

Published on 08 May 2025

Significance of gene therapy in neurodegenerative diseases

in Neurodegeneration

Lingling Wang
Lin Ma
Zihan Gao
Ying Wang
Jiaoxue Qiu

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1515255

7,637 views
3 citations

Editorial

Published on 08 May 2025

Editorial: Olfactory dysfunction in neurodegenerative diseases

in Neurodegeneration

Debanjan Dasgupta
Thomas Heinbockel
Swagata Ghatak

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1611870

2,966 views

Review

Published on 07 May 2025

The roles of microglia and astrocytes in neuroinflammation of Alzheimer’s disease

in Neurodegeneration

Jialin Han
Zhi Zhang
Pengfei Zhang
Qian Yu
Qian Cheng
Zhiming Lu
Shuai Zong

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1575453

11,598 views
20 citations

Original Research

Published on 07 May 2025

TREM2 supports neuronal protection and microglial reactivity without an effect on misfolded protein deposition in chronic neurodegenerative prion disease

in Neurodegeneration

Sarah M. Carpanini
Barry M. Bradford
Alessio Alfieri
Pedro Piccardo
Jimena Monzón-Sandoval
Deborah Brown
Aileen Boyle
Aleksandra Pokrovskaya
Neil A. Mabbott
Jean Manson

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1525017

4,028 views

Original Research

Published on 06 May 2025

NFκB1: a common biomarker linking Alzheimer's and Parkinson's disease pathology

in Neurodegeneration

Adam Cunningham
Emma Barrett
Sebastian Risch
Peter H. U. Lee
Chan Lee
Abhay Moghekar
Prabir Patra
Joon W. Shim

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1589857

5,789 views
3 citations

Original Research

Published on 29 Apr 2025

Peak alpha frequency and alpha power spectral density as vulnerability markers of cognitive impairment in Parkinson’s disease: an exploratory EEG study

in Neurodegeneration

Yuqing Zhao
Jiayu Cai
Jian Song
Haoran Shi
Weicheng Kong
Xinlei Li
Wei Wei
Xiehua Xue

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1575815

3,691 views
7 citations

Review

Published on 29 Apr 2025

Comparative analysis of neuroinflammatory pathways in Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis: insights into similarities and distinctions

in Neurodegeneration

Julia Doroszkiewicz
Izabela Winkel
Barbara Mroczko

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1579511

6,502 views
15 citations

Review

Published on 28 Apr 2025

VPS13 and bridge-like lipid transporters, mechanisms, and mysteries

in Neurodegeneration

Laura Elizabeth Swan

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1534061

4,953 views
5 citations

Original Research

Published on 28 Apr 2025

Sweet spot mapping and structural connectivity in subthalamic stimulation: predicting neuropsychiatric outcomes in Parkinson’s disease

in Neurodegeneration

Jiuqi Yan
Jian Sun
Xiang Wei
Chang Qiu
Liang Zhao
Bei Luo
Wenwen Dong
Jingxuan Liu
Guanghan Lu
Wenbin Zhang

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1577588

3,261 views

Review

Published on 23 Apr 2025

Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases

in Neurodegeneration

Fengjiao Wang
Guangjie Zhang
Qingfeng Zhai

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1576773

9,097 views
5 citations

Clinical Trial

Published on 16 Apr 2025

16 weeks of moderate intensity resistance exercise improves strength but is insufficient to alter brain structure in Gulf War Veterans with chronic musculoskeletal pain: a randomized controlled trial

in Neurodegeneration

Stephanie M. Van Riper
Jacob V. Ninneman
Aaron J. Stegner
Brady A. Riedner
Laura D. Ellingson
Ryan J. Dougherty
Patrick J. O’Connor
Gunnar A. Roberge
Andrew L. Alexander
Doug C. Dean

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1488397

3,096 views

Editorial

Published on 10 Apr 2025

Editorial: Translational research in hereditary spastic paraplegias: filling the diagnosis gap and therapeutic perspectives

in Neurodegeneration

Andrea Martinuzzi
Craig Blackstone
Giovanni Stevanin

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1595717

3,712 views

Review

Published on 08 Apr 2025

The interplay between α-synuclein aggregation and necroptosis in Parkinson’s disease: a spatiotemporal perspective

in Neurodegeneration

Haoran Xiang

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1567445

4,054 views
8 citations

Original Research

Published on 01 Apr 2025

Intrastriatal injection of alpha-synuclein preformed fibrils to rats results in L-DOPA reversible sensorimotor impairments and alterations in non-motor function

in Neurodegeneration

Sheila M. Fleming
Sophia Scott
Edward J. Hamad
Danielle E. Herman
John G. Holden
Lily Yan
Katrina Linning-Duffy
Christopher J. Kemp
Joseph R. Patterson
Kathryn M. Miller

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1556447

4,144 views
1 citation

Review

Published on 27 Mar 2025

α-synuclein and tau: interactions, cross-seeding, and the redefinition of synucleinopathies as complex proteinopathies

in Neurodegeneration

Francisco J. Padilla-Godínez
Eunice Ruth Vázquez-García
María Isabel Trujillo-Villagrán
Luis O. Soto-Rojas
Marcela Palomero-Rivero
Omar Hernández-González
Francisco Pérez-Eugenio
Omar Collazo-Navarrete
Oscar Arias-Carrión
Magdalena Guerra-Crespo

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1570553

8,065 views
18 citations

Original Research

Published on 25 Mar 2025

Association between serum sodium and sporadic Parkinson’s disease

in Neurodegeneration

Wen Zhou
Qingqing Xia
Duan Liu
Jun-ying Li
Liang Gong

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1555831

3,791 views
2 citations

Editorial

Published on 18 Mar 2025

Editorial: Innovative approaches to catalyze preclinical and clinical research on amyotrophic lateral sclerosis (ALS) and related disorders

in Neurodegeneration

Thibaut Burg
Laura Tzeplaeff
Raphaelle Cassel
Paul Lingor

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1582539

2,140 views

Perspective

Published on 17 Mar 2025

High efficacy therapy to prevent the formation of meningeal tertiary lymphoid organs after CXCL13 index screening in early multiple sclerosis

in Neurodegeneration

Ana C. Londoño
Carlos A. Mora

Frontiers in Neuroscience

doi 10.3389/fnins.2025.1558810

1,918 views

2,274 articles

articles

Bidirectional modulation of Alzheimer’s disease via gut microbiota: rescue by fecal transplantation from healthy donors and aggravation by colitis-associated dysbiosis

Expression and potential regulatory mechanism of cellular senescence-related genes in Alzheimer’s disease based on single-cell and bulk RNA datasets

Differential retinal ganglion cell resilience to optic nerve injury across vertebrate species

Improved dementia screening for elderly with low education in South Korea using the Cognitive Impairment Screening Test (CIST)

Biological engineering approaches for modulating the pathological microenvironment and promoting axonal regeneration after spinal cord injury

The key role of the ferroptosis mechanism in neurological diseases and prospects for targeted therapy

Significance of gene therapy in neurodegenerative diseases

Editorial: Olfactory dysfunction in neurodegenerative diseases

The roles of microglia and astrocytes in neuroinflammation of Alzheimer’s disease

TREM2 supports neuronal protection and microglial reactivity without an effect on misfolded protein deposition in chronic neurodegenerative prion disease

NFκB1: a common biomarker linking Alzheimer's and Parkinson's disease pathology

Peak alpha frequency and alpha power spectral density as vulnerability markers of cognitive impairment in Parkinson’s disease: an exploratory EEG study

Comparative analysis of neuroinflammatory pathways in Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis: insights into similarities and distinctions

VPS13 and bridge-like lipid transporters, mechanisms, and mysteries

Sweet spot mapping and structural connectivity in subthalamic stimulation: predicting neuropsychiatric outcomes in Parkinson’s disease

Role and mechanism of molecular hydrogen in the treatment of Parkinson’s diseases

16 weeks of moderate intensity resistance exercise improves strength but is insufficient to alter brain structure in Gulf War Veterans with chronic musculoskeletal pain: a randomized controlled trial

Editorial: Translational research in hereditary spastic paraplegias: filling the diagnosis gap and therapeutic perspectives

The interplay between α-synuclein aggregation and necroptosis in Parkinson’s disease: a spatiotemporal perspective

Intrastriatal injection of alpha-synuclein preformed fibrils to rats results in L-DOPA reversible sensorimotor impairments and alterations in non-motor function

α-synuclein and tau: interactions, cross-seeding, and the redefinition of synucleinopathies as complex proteinopathies

Association between serum sodium and sporadic Parkinson’s disease

Editorial: Innovative approaches to catalyze preclinical and clinical research on amyotrophic lateral sclerosis (ALS) and related disorders

High efficacy therapy to prevent the formation of meningeal tertiary lymphoid organs after CXCL13 index screening in early multiple sclerosis