CASE REPORT article
Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1544858
This article is part of the Research TopicThe Gut Microbiome's Role in Gastric Cancer: Mechanisms and TherapiesView all 11 articles
Mucosal healing of ileum mucosa-associated lymphoid-tissue lymphoma after Helicobacter pylori eradication: a case report and literature review
Provisionally accepted
- Tianjin Medical University General Hospital, Tianjin, China
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Mucosa-associated lymphoid-tissue (MALT) lymphoma of small intestine is relatively rare, and the treatment guideline has not been established yet. Here, we present a case of MALT lymphoma in the terminal ileum, which regressed after Helicobacter pylori (H. pylori) eradication. A 53-year-old man had complained of abdominal discomfort and underwent a gastrointestinal endoscopic examination.H. pylori associated erosive gastritis was diagnosed, and superficial ulcerated lesions were also found in the terminal ileum. Histopathologic examination and immunohistochemical analyses of ileal biopsy specimens confirmed the diagnosis of MALT lymphoma. No distant lymph node metastasis or other organs involvement was detected in Positron emission tomography/computed tomography. Surprisingly, the ileum reached mucosal healing after quadruple therapy regimens for H. pylori eradication without additional treatments. There were no signs of recurrence during the follow-up for 18 months. The unique case which located only in the ileum revealed that eradication of H. pylori might be an effective treatment and deserved further studies. Moreover, we also provide a detailed overview of recently published literature regarding the eradication treatment for intestinal MALT lymphoma.
Keywords: Mucosa-associated lymphoid tissue, Lymphoma, Ileum, Helicobacter pylori eradication, case report
Received: 13 Dec 2024; Accepted: 31 Jul 2025.
Copyright: © 2025 Huang, Jiang, Jiang, Wang, Liu and Cao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tianyu Liu, Tianjin Medical University General Hospital, Tianjin, China
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