REVIEW article
Front. Oncol.
Sec. Thoracic Oncology
Volume 15 - 2025 | doi: 10.3389/fonc.2025.1550075
This article is part of the Research TopicProgress in Molecular Mechanisms and Targeted Therapies for Solid Tumor MicroenvironmentsView all 9 articles
Endoplasmic reticulum stress in lung cancer
Provisionally accepted
- 1Deqing People's Hospital, Huzhou, China
- 2First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian Province, China
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Endoplasmic reticulum is the primary site of eukaryotic cells involved in biosynthesis, lipid metabolism, glucose metabolism, protein folding and secretion. Multiple factors in the tumor microenvironment may induce the accumulation of unfolded and misfolded proteins in the endoplasmic reticulum and trigger endoplasmic reticulum (ER) stress. Adaptive mechanisms including unfolded protein response (UPR) and endoplasmic reticulum associated degradation (ERAD) are activated in response to ER stress. Previous studies have revealed that ER stress may participate in epithelial mesenchymal transformation, apoptosis, metabolic regulation and drug resistance of lung cancer cells. Herein, we summarized the potential effects and regulatory mechanisms of ER stress on the biological process of lung cancer, which may provide scientific significance and clinical value for elucidating the adaptability of lung cancer cells under stress and developing novel targeted therapies.
Keywords: lung cancer, Tumor Microenvironment, Endoplasmic Reticulum Stress, Unfolded Protein Response, targeted therapy
Received: 22 Dec 2024; Accepted: 25 Aug 2025.
Copyright: © 2025 Zhang, Lin, Jin, Mao, Wang, Ma and Lao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Donghuan Zhang, Deqing People's Hospital, Huzhou, China
Zhenghong Lao, Deqing People's Hospital, Huzhou, China
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