Progress in Molecular Mechanisms and Targeted Therapies for Solid Tumor Microenvironments

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SYSTEMATIC REVIEW

Published on 14 Aug 2025

Comparative analysis of first-generation epidermal growth factor receptor inhibitors combined with chemotherapy versus third-generation epidermal growth factor receptor inhibitors in the treatment of advanced non-small cell lung cancer: a systematic review and meta-analysis

Siyan Peng
Zhixin Yu
Honglin Zhu
Chuwen Liang
Huijuan Qiu
Shaodong Hong
Yixin Zhou

doi 10.3389/fphar.2025.1586332

221 views

ORIGINAL RESEARCH

Published on 12 Aug 2025

Comprehensive single-cell sequencing reveals the tumor microenvironment and tumor-specific characteristics in trachea squamous cell carcinoma

Hongwu Wang
Hongli Li
Heng Zou
Han Meng
Yan Liu
Chengjun Ban
Weixia Yu
Miao Cheng
Jun Teng

doi 10.3389/fonc.2025.1575647

343 views

REVIEW

Accepted on 22 Jul 2025

The potential role of miR-155 in the tumorigenesis of cervical cancer

Xu Chen
Liying Zheng
Xianxu Zeng

doi 10.3389/fcell.2025.1572373

130 views

REVIEW

Published on 09 Jul 2025

Harnessing the interaction between redox signaling and senescence to restrain tumor drug resistance

Hao Wu
Yang Yu
Xiangning He
Yanju Gong
Jianqing Huang
Peijie Wu

doi 10.3389/fcell.2025.1639772

944 views

REVIEW

Published on 24 Jun 2025

Plant-derived extracellular vesicles as a novel tumor-targeting delivery system for cancer treatment

Hanjin Wu
Mengya Shi
Liwei Meng
Jie Qiu
Yuancong Jiang
Da Qian
Fengqing Shen

doi 10.3389/fcell.2025.1589550

1,402 views

ORIGINAL RESEARCH

Published on 19 Jun 2025

Machine learning developed an immune evasion signature for predicting prognosis and immunotherapy benefits in lung adenocarcinoma

Dongxiao Ding
Gang Huang
Liangbin Wang
Ke Shi
Junjie Ying
Wenjun Shang
Li Wang
Chong Zhang
Maofen Jiang
Yaxing Shen

doi 10.3389/fcell.2025.1622345

1,019 views

ORIGINAL RESEARCH

Published on 04 Jun 2025

Identifying a prognostic signature for clear cell renal cell carcinoma: the convergence of single-cell and bulk sequencing with machine learning

Yude Hong
Xiao Hu
Libo Chen
Mingyong Li
Mingxiao Zhang
Weiming Deng

doi 10.3389/fcell.2025.1560095

1,383 views

REVIEW

Published on 19 Feb 2025

The role of tenascin-C in tumor microenvironments and its potential as a therapeutic target

Yaran Wang
Xiaohui Wen
Chao Su
Yanyi You
Ziqing Jiang
Qin Fan
Daoqi Zhu

doi 10.3389/fcell.2025.1554312

1,934 views

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Frontiers in Cell and Developmental Biology

Cancer Cell Biology

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Articles

Comparative analysis of first-generation epidermal growth factor receptor inhibitors combined with chemotherapy versus third-generation epidermal growth factor receptor inhibitors in the treatment of advanced non-small cell lung cancer: a systematic review and meta-analysis

Comprehensive single-cell sequencing reveals the tumor microenvironment and tumor-specific characteristics in trachea squamous cell carcinoma

The potential role of miR-155 in the tumorigenesis of cervical cancer

Harnessing the interaction between redox signaling and senescence to restrain tumor drug resistance

Plant-derived extracellular vesicles as a novel tumor-targeting delivery system for cancer treatment

Machine learning developed an immune evasion signature for predicting prognosis and immunotherapy benefits in lung adenocarcinoma

Identifying a prognostic signature for clear cell renal cell carcinoma: the convergence of single-cell and bulk sequencing with machine learning

The role of tenascin-C in tumor microenvironments and its potential as a therapeutic target

Frontiers in Cell and Developmental Biology

Cancer Cell Biology