Your new experience awaits. Try the new design now and help us make it even better

CASE REPORT article

Front. Oncol.

Sec. Cancer Imaging and Image-directed Interventions

Volume 15 - 2025 | doi: 10.3389/fonc.2025.1638850

Imaging Features of Pancreatic Extragastrointestinal Stromal Tumors: A Case Report and Literature Review

Provisionally accepted
Jian-Xia XuJian-Xia Xu1Meng-Yin GuMeng-Yin Gu1Yi-Hua WangYi-Hua Wang1Xiao-Shan HuangXiao-Shan Huang1Jia-Qi DuanJia-Qi Duan1Xiong-Zhong ZhengXiong-Zhong Zheng1Xi-Xi ChenXi-Xi Chen2Ri-Sheng YuRi-Sheng Yu3*Jun-Yi XiangJun-Yi Xiang1*
  • 1Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China
  • 2The First People's Hospital of Wenling, Wenling, China
  • 3The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China

The final, formatted version of the article will be published soon.

Select one of your emails

You have multiple emails registered with Frontiers:

Notify me on publication

Please enter your email address:

If you already have an account, please login

You don't have a Frontiers account ? You can register here

Pancreatic extra-gastrointestinal stromal tumors (pEGISTs) are exceedingly rare, accounting for less than 5% of all extra-gastrointestinal stromal tumors (EGISTs). We report a case involving a 62-year-old woman who presented with a hypervascular pancreatic mass.Postoperative histopathological examination confirmed the diagnosis of a gastrointestinal stromal tumor (GIST). The neoplastic cells exhibited a spindle-shaped morphology without evident necrosis on histologic sections. Immunohistochemical analysis demonstrated strong, diffuse positivity for CD117, DOG-1, and CD34. Notably, the imaging characteristics of this pEGISTs displayed several distinctive features, including intralesional "island-like" enhancement, peripheral nodular enhancement, and prominent vascular "staghorn" patterns. Although histopathology remains the gold standard for definitive diagnosis of pEGISTs, correlating clinical presentation with these unique radiologic features can substantially improve diagnostic accuracy for radiologists.Additionally, we provide a comprehensive review and discussion of the current literature on the clinical and imaging hallmarks of pEGISTs.

Keywords: Pancreas, Extragastrointestinal stromal tumors, literature review, case report, Imaging features

Received: 31 May 2025; Accepted: 09 Jul 2025.

Copyright: © 2025 Xu, Gu, Wang, Huang, Duan, Zheng, Chen, Yu and Xiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Ri-Sheng Yu, The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou, China
Jun-Yi Xiang, Second Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Supplementary Material