Frontiers in Oncology | Cancer Genetics

Original Research

Accepted on 22 Sep 2025

Whole-Exome Sequencing in Saudi Colorectal Cancer Patients Reveals Distinct Mutational Patterns and Population Specific Pathogenic Variants

in Cancer Genetics

Hanan E Alatwi
Amnah A Alharbi
Rashid Mir
Othman Alzahrani
Abdulrahman H Alessa
Yousef MohammedRabaa Hawsawi
Mohammed Ali Arishi
Aziz Dhaher Albalawi

Frontiers in Oncology

doi 10.3389/fonc.2025.1679528

Case Report

Accepted on 22 Sep 2025

Paired DNA/RNA testing uncover a deep intronic PTEN pathogenic variant associated with clinical Cowden Syndrome a Case Report

in Cancer Genetics

Michael J Hall
Dong Won Kim
Devang Namjoshi
Michelle McSweeny
Marcy Richardson
Ashley PL Marsh
Felicia Hernandez
Demitrios Dedousis

Frontiers in Oncology

doi 10.3389/fonc.2025.1679432

Original Research

Accepted on 22 Sep 2025

Unraveling the Role of Coagulation-related Genes in Esophageal Squamous Cell Carcinoma: Development of a Prognostic Model and Exploration of Potential Clinical Significance

in Cancer Genetics

Langlang Deng
Chen Fang
Weiran Zhang
Zheng Zhu
Yu Gu
Pinchao Gu
Xiaoyan Tan
Jiamin Yuan
Yu Feng
Haitao Ma

Frontiers in Oncology

doi 10.3389/fonc.2025.1573279

Original Research

Published on 22 Sep 2025

Association between genetic mutations in lung adenocarcinoma and adult body mass index: a retrospective cohort study

in Cancer Genetics

Yan qiao Wu
Lei Yang
Depeng Jiang

Frontiers in Oncology

doi 10.3389/fonc.2025.1661143

565 views

Correction

Accepted on 17 Sep 2025

Authorship change

in Cancer Genetics

Liang Lin
Zuolian Xie
Peilin Zhong
Jian Chen
Ning Ma
Ling Li
An Lin
Li Chen

Frontiers in Oncology

doi 10.3389/fonc.2025.1697794

505 views

Review

Accepted on 15 Sep 2025

Super-enhancer DNA methylation in cancer: The mechanism of action and therapeutic directions

in Cancer Genetics

Yue Bi
Kang Zou
Ke Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1610579

630 views

Review

Published on 15 Sep 2025

The role of extrachromosomal DNA in tumorigenesis and progression

in Cancer Genetics

Xiaoyang Ma
Xiaolin Yu
Chuan Wu
Lixing Song

Frontiers in Oncology

doi 10.3389/fonc.2025.1665024

705 views

Original Research

Accepted on 12 Sep 2025

Identification and prognostic prediction of high-risk multiple myeloma by exosomal microRNA

in Cancer Genetics

Tian Ying
Wenjiao Tang
Chunlan Zhang
Juan Xu
Yunfan Yang
Qinyu Liu
Xushu Zhong
Jie Wang
Caigang Xu

Frontiers in Oncology

doi 10.3389/fonc.2025.1659708

924 views

Review

Accepted on 08 Sep 2025

Research progress on sirtuin family genes in colorectal cancer

in Cancer Genetics

Tong Liu
Tianhua Wu
Wei Li
Lijun Luo
Zhang Minglin

Frontiers in Oncology

doi 10.3389/fonc.2025.1570030

789 views

Original Research

Accepted on 08 Sep 2025

Transcriptome Analyses Identify Deregulated 10 Hub Genes and Essential Molecular Mechanisms in Early Onset Colorectal Cancer

in Cancer Genetics

Hieu Duc Nguyen
Ming-Jenn Chen
Chung Ying Lee
Yi-Chun Ni
Ke Xin Yee
Yung-Fu Wu
Kuen-Haur Lee

Frontiers in Oncology

doi 10.3389/fonc.2025.1655143

655 views

Original Research

Published on 02 Sep 2025

Integrated single-cell and bulk RNA-seq analysis reveals prognostic stemness genes in leiomyosarcoma

in Cancer Genetics

Aiju Lou
Yu Cai
Tuquan Zheng
Long Zhang
Yupeng Hu
Huachi Li
Lang Ying

Frontiers in Oncology

doi 10.3389/fonc.2025.1604413

1,168 views

Original Research

Published on 01 Sep 2025

Combination of BRCA deep targeted sequencing and shallow whole genome sequencing to detect homologous recombination deficiency in ovarian cancer

in Cancer Genetics

Thien-Phuc Nguyen Hoang
Nam H. B. Tran
Tien Anh Nguyen
My T. T. Ngo
Anh Duong Doan
Du Quyen Nguyen
Hung Sang Tang
Duy Sinh Nguyen
Cam Tu Nguyen Thi
Thanh Thuy Do Thi

Frontiers in Oncology

doi 10.3389/fonc.2025.1593881

1,249 views

Review

Published on 01 Sep 2025

Interactions between ALKBH5 and reader proteins in tumors: functions and molecular mechanisms

in Cancer Genetics

Jiahui Ou
Bingchen Liu
Yi Yu
Yingchun He
Yuyu Gao
Lingli Chen
Xia Chen
Huai Tao

Frontiers in Oncology

doi 10.3389/fonc.2025.1611007

746 views

Review

Published on 27 Aug 2025

POLE-mutated endometrial cancer: new perspectives on the horizon?

in Cancer Genetics

Daniele Fanale
Lidia Rita Corsini
Paola Piraino
Erika Pedone
Chiara Brando
Tancredi Didier Bazan Russo
Pietro Ferraro
Alisia Simone
Silvia Contino
Ornella Prestifilippo

Frontiers in Oncology

doi 10.3389/fonc.2025.1633260

1,222 views

Original Research

Published on 27 Aug 2025

Integration of single-cell and bulk RNA sequencing to identify unique tumor stem cells and construct novel prognostic markers for assessing ESCA prognosis and drug sensitivity

in Cancer Genetics

Jia Shi
Danni Qiao
Qiongyang Lv
Yaliang Fan
Haibin Yu
Guiming Hu
Longhao Wang
Beibei Sha

Frontiers in Oncology

doi 10.3389/fonc.2025.1649877

858 views

Original Research

Published on 22 Aug 2025

Application of low-coverage whole-genome sequencing technology in risk stratification of colorectal adenomas

in Cancer Genetics

Guo Zhili
Xue Yuyue
Yu Fang
Ren Dianqun
Zhang Qin
Liu Jie

Frontiers in Oncology

doi 10.3389/fonc.2025.1591548

966 views