Frontiers in Oncology | Cancer Molecular Targets and Therapeutics

Case Report

Accepted on 16 Jul 2025

A Rare Case of MET-Amplified Gastric Cancer with Systemic Metastasis: Remarkable Efficacy of Crizotinib and the Role of Precision Medicine

in Cancer Molecular Targets and Therapeutics

Yan Shen
Yaxin Xu
Jing Sun

Frontiers in Oncology

doi 10.3389/fonc.2025.1555801

Original Research

Accepted on 16 Jul 2025

Combined treatment with CDK4/6, CDK2, and CXCR1/2 inhibitors effectively halt the growth of BRAF wild-type melanoma tumors

in Cancer Molecular Targets and Therapeutics

Jinming Yang
Chi Yan
Weifeng Luo
Patricia A Ward
Sheau-Chiann Chen
John Zebala
Dean Maeda
Ann Richmond

Frontiers in Oncology

doi 10.3389/fonc.2025.1609735

Review

Accepted on 16 Jul 2025

The Pathogenesis of Benign Prostatic Hyperplasia and the Roles of Prdx3, Oxidative Stress, Pyroptosis and Autophagy: A Review

in Cancer Molecular Targets and Therapeutics

Junjie Xiang
Yuxuan Zheng
Diang Chen
Yining Zeng
Jingqi Zhang
Degui Chang
Cheng Chang

Frontiers in Oncology

doi 10.3389/fonc.2025.1579539

Review

Published on 16 Jul 2025

Polyploid giant cancer cells and tumor budding: translation from basic research to clinical application

in Cancer Molecular Targets and Therapeutics

Peng Huang
Rong Wu
Zhimou Yang
Yuwei Li
Fei Fei
Yongjun Yu

Frontiers in Oncology

doi 10.3389/fonc.2025.1611920

171 views

Original Research

Accepted on 15 Jul 2025

Prognostic Stratification Through Smoking Status and Cumulative Smoking Dose in Advanced Non-Small Cell Lung Cancer Immunotherapy: A Dose-Dependent Real-World Analysis

in Cancer Molecular Targets and Therapeutics

Lan Yang
Haoyu Wang
Panwen Tian
Weimin Li

Frontiers in Oncology

doi 10.3389/fonc.2025.1590825

111 views

Brief Research Report

Accepted on 14 Jul 2025

Current practices and challenges in the management of cancer-associated thrombosis: a survey of Italian oncologists

in Cancer Molecular Targets and Therapeutics

Andrea Antonuzzo
Paola Ermacora
Gaetano Lanzetta
Maurizio Lucchesi
Marco Platania
Paolo Bossi

Frontiers in Oncology

doi 10.3389/fonc.2025.1579464

Original Research

Accepted on 14 Jul 2025

Oxidative Stress-Related Genes in Uveal Melanoma: the Roles of CALM1 in Modulating Oxidative Stress, Apoptosis, and Prognostic Significance

in Cancer Molecular Targets and Therapeutics

Yue Wu
Xiaoyan Cai
Menghan Hu
Runyan Cao
Yong Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1618601

Review

Accepted on 14 Jul 2025

Physical Activity and Glioblastoma: A Paradigm Shift in Neuro-Oncology Therapy

in Cancer Molecular Targets and Therapeutics

Lin Xie
Feng Wang

Frontiers in Oncology

doi 10.3389/fonc.2025.1638060

174 views

Original Research

Published on 14 Jul 2025

Elevated plasma levels of WAP four-disulfide core domain 2 as a potential prognostic biomarker for various cancers

in Cancer Molecular Targets and Therapeutics

Makoto Watanabe
Katsuaki Ieguchi
Nobuyuki Onishi
Takashi Shimizu
Ryotaro Ohkuma
Risako Suzuki
Emiko Mura
Nana Iriguchi
Tomoyuki Ishiguro
Yuya Hirasawa

Frontiers in Oncology

doi 10.3389/fonc.2025.1614102

497 views

Case Report

Published on 14 Jul 2025

Case Report: Gefitinib in EGFR 19del recurrent aggressive fibromatosis

in Cancer Molecular Targets and Therapeutics

Yanjing Guo
Jingjing Wu
Qianming Bai
Juefeng Wan
Qifeng Wang
Xinhong He
Xiaowei Zhang
Zhiguo Luo
Liju Xing
Xin Liu

Frontiers in Oncology

doi 10.3389/fonc.2025.1537714

254 views

Original Research

Published on 14 Jul 2025

Glyoxalase 1 gene expression in various types of cancer cells immunopathology: a pan-cancer analysis study

in Cancer Molecular Targets and Therapeutics

Ali M. Alaseem
Jehad A. Aldali
Glowi Alasiri
Muhanad Alhujaily
Khalid I. AlHussaini
Osama A. AlKhamees

Frontiers in Oncology

doi 10.3389/fonc.2025.1610886

438 views

Case Report

Accepted on 11 Jul 2025

A Case Report of advanced small intestinal stromal tumor with KIT gene mutation and BRCA2 deletion after multi-line treatments

in Cancer Molecular Targets and Therapeutics

Shiyun Cui
Lei Fan
Yu Bai
Xinnan Sun
Cai Yucheng
Jingqi Dai
Ting Wang
Chongqi Sun
Rong Wang
Lianke Liu

Frontiers in Oncology

doi 10.3389/fonc.2025.1630699

Original Research

Published on 11 Jul 2025

Analysis of cancer-associated glycosyltransferases reveals novel targets of non-small cell lung cancer pathogenesis

in Cancer Molecular Targets and Therapeutics

Chang Liu
Thomas van Ee
Jurriaan Janssen
Ernesto Rodríguez
Yongsoo Kim
Teodora Radonic
Victor W. van Beusechem
Marieke F. Fransen
Idris Bahce
Yvette van Kooyk

Frontiers in Oncology

doi 10.3389/fonc.2025.1601368

527 views

Review

Published on 11 Jul 2025

The NLRP3 inflammasome in urogenital cancers: structure, dual function, and therapeutic potential

in Cancer Molecular Targets and Therapeutics

Weiming Sun
Ruiting Ma
Rui Zhao
Jiaju Tian
Wenhui Liu

Frontiers in Oncology

doi 10.3389/fonc.2025.1593774

255 views

Systematic Review

Accepted on 10 Jul 2025

Immune Checkpoint Inhibitors in Pancreatic Adenocarcinoma: A Systematic Review and Meta-Analysis of Clinical Outcomes

in Cancer Molecular Targets and Therapeutics

Aisha Al-Khinji
Dhafer Malouche
Noora Al Korbi
Shaikha Al Kuwari
Abdullatif Al Hor

Frontiers in Oncology

doi 10.3389/fonc.2025.1569884

122 views

Original Research

Published on 10 Jul 2025

Lamins regulate cancer cell plasticity and chemosensitivity

in Cancer Molecular Targets and Therapeutics

Guofang Chen
Tingyi Wei
Ao Huang
Junwei Shen
Furong Ju
Shichao Huang
Haisen Li

Frontiers in Oncology

doi 10.3389/fonc.2025.1599175

343 views