SYSTEMATIC REVIEW article

Front. Pain Res., 15 April 2025

Sec. Non-Pharmacological Treatment of Pain

Volume 6 - 2025 | https://doi.org/10.3389/fpain.2025.1447075

Assessment of non-pharmacological nursing strategies for pain management in tumor patients: a systematic review and meta-analysis


Shen YanShen YanFeng YanFeng YanPei LiangyuPei LiangyuXu Fei

Xu Fei*
  • Department of Cancer V, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

Summary background: Cancer is a multifactorial disease associated with intense pain and fatigue. Pain is the main discomfort experienced during cancer treatment, particularly as a major side effect of chemotherapy.

Objective: This study has aimed to investigate the effectiveness of non-pharmacological nursing strategies, including reflexology, aromatherapy, acupressure, massage therapy and acupuncture, in the management of cancer-associated pain. Moreover, it provides evidence-based recommendations for integrating these interventions into standard pain management protocols.

Search methodology: We gathered data from three major online databases; PubMed, the Cochrane Library and Embase. For the analysis, we exclusively targeted randomized controlled trials (RCTs) assessing the effectiveness of non-pharmacological interventions in managing cancer-related pain. No language restrictions were applied, and pain was considered the primary outcome measure.

Results: Seventeen RCTs (n = 1,070) were included in this meta-analysis from 166 eligible studies. The pooled effect size demonstrated that all evaluated non-pharmacological nursing strategies, including aromatherapy, massage, reflexology, acupressure and acupuncture significantly reduced cancer-related pain compared to usual care (p < 0.001). Moreover, the reflexology and massage showed negligible heterogeneity among other interventions.

Conclusion: This meta-analysis found the significant effectiveness of non-pharmacological nursing strategies, particularly reflexology and massage in reducing cancer-related pain. The findings support their integration into clinical practice, providing evidence-based recommendations for enhancing standard pain management protocols.

1 Introduction

In cancer, pain is a severe discomfort and pain management is a highly critical aspect of patient care for cancer survivors. Comprehensive strategies are based on the patient’s condition, pain severity and disease pathogenesis (1). Despite the advancements and novelty in the healthcare system, the optimization of pain management remains a challenging step. However, nursing strategies for pain assessment and management play an important role in the survival of cancer survivors (24). We aimed to evaluate the effectiveness of non-pharmacological nursing interventions for the pain management among tumor patients in this systematic meta-analysis.

Cancer-related pain involves a complex interplay of psychological, physiological and social factors that ultimately have a significant impact on patients’ quality of life and the healthcare system (5). According to the World Health Organization (WHO), effective pain management is a fundamental human right, which emphasizes the importance of comprehensive approaches to alleviate suffering and improve quality of life (6). Nurses are frontline healthcare providers who play a significant role in pain assessment, therapeutic intervention and monitoring. Moreover, nurses can develop therapeutically effective strategies that are important for tumor-related pain management (7).

In the cancer care, pain management involves both pharmacological and non-pharmacological nursing approaches. In the pharmacological approach, analgesics are administered via several routes as prescribed by the oncologist. while, the therapeutic effectiveness of the prescribed analgesic is monitored and the dosage is adjusted or the medications are switched as needed (8, 9). In case of non-pharmacological interventions aromatherapy, massage, reflexology, acupressure and acupuncture are included (10). In this study, we gathered data on non-pharmacological strategies to evaluate their effectiveness in managing cancer-related pain.

Aromatherapy is a widely recognized therapeutic intervention for pain management. Moreover, several studies have demonstrated its effectiveness in reducing cancer-related pain. It is administered through inhalation, massage, or, in some cases, oral administration under professional supervision. Notably, the combination of aromatherapy with massage is widely practiced and has been proven effective for pain alleviation, as massage with essential oils is frequently used to reduce discomfort in cancer patients (11). In reflexology, pressure is applied to specific reflex points on the feet or hands to induce relaxation and promote healing. Foot reflexology is a highly practiced nursing strategy for alleviating pain in cancer patients (12). Similarly, acupressure, an ancient healing technique, offers potential relief for cancer-related pain. In this intervention, pressure is applied to specific points on the body, which stimulates the body’s natural healing abilities and promotes relaxation. Investigational studies revealed the significant effectiveness of acupressure for pain, anxiety and quality of life management among cancer patients (13). Furthermore, acupuncture is a traditional Chinese therapy in which the energy flow is rebalanced by inserting thin needles into specific points on the body, which ultimately promotes healing. Individual responses may vary; many individuals find relief from symptoms and experience improved quality of life through this holistic approach (14, 15).

Given the growing interest in non-pharmacological interventions, this study hypothesizes that integrating evidence-based non-pharmacological nursing strategies, including aromatherapy, massage, acupressure, acupuncture and reflexology can significantly enhance pain management outcomes in cancer patients.

2 Materials and methods

2.1 Literature search and search strategy

During April–May 2024, we extracted relevant data from three databases, namely, the Cochrane Library, PubMed, and Embase. The relevant potential studies between 1990 and 2023 were included in this meta-analysis. For the data search, several Medical Subject Headings (MeSH) terms were used: “aromatherapy”, “cancer-related pain”, “cancer or malignancies”, “massage”, “reflexology”, “acupressure” and “acupuncture”. We included the data from search databases without language limitations. The study selection process is illustrated in the PRISMA flow chart (Figure 1).

Figure 1
PRISMA flow diagram outlining the study selection process for a meta-analysis. From 788 records identified across three databases, 113 duplicates were removed. After screening 675 records, 29 were excluded based on abstract review and 480 more during retrieval. Of 166 full-text articles assessed, 149 were excluded due to duplicate data, small sample size, multifactor data, or irrelevant outcomes. Seventeen studies were included in the final quantitative synthesis.

Figure 1. PRISMA flow diagram illustrating the study selection process, including the identification, screening, eligibility assessment and final inclusion of studies for meta-analysis.

2.2 Inclusion and exclusion criteria

The following inclusion criteria were considered for the data retrieval and measuring effects: (1) the targeted population included humans, (2) the study design was randomized controlled trials, (3) the population included adult males and females of all age groups, (4) only cancer patients were included, (5) research studies with sufficient sample sizes, based on statistical guidelines and previous research, were included to ensure reliable findings, (6) the experimental group received aromatherapy or massage or reflexology or acupressure or acupuncture to relieve pain, while the control group received usual care, (7) data from various periods were included to ensure complete coverage of the available literature, and (8) studies with robust statistical analyses, validated findings and clearly defined methodologies were included.

During the study selection process, to uphold the exclusion criteria, the following points were considered: (1) studies with unpublished data were restricted, (2) animal trials were excluded, (3) articles lacking proper methodology and outcomes were eliminated, and (4) derivative data sources such as review articles were limited.

2.3 Data analysis and validity assessment

To ensure the data accuracy and reliability, two independent reviewers screened and extracted the data from each study. Any discrepancies were resolved via the consultation with a third reviewer and no language restrictions were imposed. We compiled the extracted standardized data into a Microsoft Excel spreadsheet, creating a comprehensive database for our meta-analysis. The characteristics of the selected research studies are summarized in Table 1, which includes the following points: first author, publication year, country of publication, population, population size, participant types, age, pain management intervention and duration of treatment, measured outcomes and treatment evaluation.

Table 1
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Table 1. Summary of the included studies on non-pharmacological nursing intervention in the pain alleviation in cancer patients including study characteristics.

For the analysis, we gathered the data and evaluated the validity across studies using a random-effects model, ensuring that the data were free from self-report bias. The extracted variables included sample sizes, means and standard deviations. Heterogeneity was quantified using the I2 statistic and assessed with Cochran’s Q test.

2.4 Risk of bias

We used the Cochrane Collaboration tool to evaluate the risk of bias in the included trials. This assessment covered the following domains: random sequence generation, allocation concealment, blinding of participants and personnel, blinding of outcome assessment and incomplete outcome data (attrition bias, referring to systematic differences between groups due to withdrawals leading to incomplete outcome data). The risk of bias assessment plot is visually summarized in Figure 2. Each domain is color-coded: green indicates low risk (+), yellow indicates unclear risk (?) and red indicates high risk (−). Most studies showed a mixture of low and unclear risks, with notably high risks in allocation concealment and blinding of participants and personnel. This comprehensive assessment highlights the variability in methodological quality among the included studies, providing a clear overview of potential biases impacting the meta-analysis.

Figure 2
Forest plot comparing mean differences in outcomes between reflexology and control groups across four studies. All studies show negative mean differences, favoring reflexology, with a pooled mean difference of −0.63 (95% CI: −0.71 to −0.54). Kim et al. 2008 contributes the highest weight at 63.8%. Heterogeneity is low (I2 = 0%), indicating consistent results across studies. The overall effect is statistically significant (Z = 14.63, P < 0.00001).

Figure 2. Risk of bias assessment for the included studies. The assessment was conducted using the Cochrane Risk of Bias Tool. Green circles (+) indicate a low risk of bias, yellow circles (?) represent an unclear risk of bias and red circles (−) denote a high risk of bias. This visual representation of outcomes provides an overview of the methodological quality and potential limitations of the studies included in the analysis.

2.5 Selectivity analysis

To ensure the accuracy and of our findings, we conducted a sensitivity analysis to assess the influence of multi-intervention studies on the meta-analysis results. Specifically, we examined the impact of the Hodgson et al. study on the pooled effect sizes of reflexology and massage therapy. However, in this study, reflexology and massage were administered separately with a washout period to minimize carryover effects and each intervention was assessed independently. This analysis aimed to determine whether the inclusion or exclusion of this study significantly altered the overall effect size. In a case, if results remain consistent with insignificant change in the overall effect size of analysis after excluding the study, confirming the robustness of the findings.

2.6 Statistical analysis

In this systematic meta-analysis, all the statistical analyses were performed using Review Manager, version 5.3 (Cochrane Collaboration, Oxford, England). We extracted the means, standard deviations (SDs) and sample sizes from the included studies. The meta-analysis was conducted in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. We used a random effects model to estimate the effective mean size and pooled estimator of the continuous outcomes. To assess heterogeneity, χ2 and I2 inconsistency statistics were calculated. If the value of Cochran’s Q test was less than 0.10 (p < 0.10), heterogeneity was considered significant.

3 Results

3.1 Description of studies

This meta-analysis included 17 RCTs. Initially, we identified 788 studies related to pain alleviation techniques in cancer patients. After critical review, 166 RCTs were selected for the eligibility stage. Finally, after screening multifactorial data, inadequate assessment methods, etc., and removing duplicate publications, a total of 17 RCTs were selected for analysis. The study design for the meta-analysis is visually depicted in the PRISMA flow chart (Figure 1). These trials were published between 1990 and 2023, with sample sizes ranging from 18 to 231 patients. All of the included studies were randomized controlled trials.

3.2 Non-pharmacological strategies to alleviate cancer-related pain

3.2.1 Aromatherapy

Based on the 4 studies with 400 samples, aromatherapy for pain management in cancer patients was significantly more effective than usual care (SMD, −0.67; 95% CI, −0.98, −0.36; p < 0.001). Between-study heterogeneity was moderate (I2 = 42%). The pooled effect size of the outcome measures demonstrated the significant effectiveness of aromatherapy in alleviating cancer-related pain (Figure 3).

Figure 3
Forest plot comparing massage versus control across seven studies on a continuous outcome. Green squares represent individual study effect sizes with 95% confidence intervals. The pooled mean difference is −0.88 with a 95% confidence interval of −1.31 to −0.45, indicating a significant effect favoring massage. Study weights vary, with the largest contribution from Chang et al. 2008. Heterogeneity is high, with I2 at 85 percent. The diamond represents the overall effect size, positioned left of zero on the x-axis, supporting the conclusion that massage is more effective than control.

Figure 3. Forest plot showing the effect of aromatherapy on pain reduction compared to the control group. The X-axis represents the mean difference with a 95% confidence interval (CI), where negative values favor aromatherapy. Each study’s effect size is depicted as a green square, with the size proportional to its weight in the meta-analysis. The black diamond represents the overall pooled estimate. moderate heterogeneity (I2 = 42%) suggests variability in study design, sample sizes or intervention protocols. The overall effect (p < 0.00001) indicates a statistically significant benefit of aromatherapy.

3.2.2 Massage therapy

Massage therapy found significant effectiveness in pain management across 5 RCTs involving 215 cancer patients, compared to the control group receiving usual care (SMD: −0.1; 95% CI: −1.08 to −0.92; p < 0.001). Notably, between-study heterogeneity was negligible (0%), highlights the consistency and reliability of the results. Moreover, to assess the impact of including the Hodgson et al. study, a sensitivity analysis was performed, revealing a substantial change in effect size upon its exclusion. Given its significant influence on the pooled results, the study was removed from the massage therapy analysis to minimize heterogeneity and ensure a more accurate estimation of the intervention’s efficacy. The pooled effect size confirmed the substantial impact of massage therapy in alleviating cancer-related pain (Figure 4).

Figure 4
Forest plot showing the comparison of acupressure versus control across three studies, with individual mean differences and 95% confidence intervals depicted as green squares. The pooled mean difference is −1.06 with a 95% confidence interval of −1.28 to −0.85, indicating a statistically significant benefit of acupressure. The largest weight is assigned to Yeh et al. 2015. Moderate heterogeneity is indicated by an I2 value of 67 percent. The overall effect, represented by a black diamond, lies entirely on the left of the null line, favoring acupressure.

Figure 4. Forest plot showing the effect of massage on pain reduction compared to the control group. The X-axis represents the mean difference with a 95% confidence interval (CI), where negative values favor massage. Each study’s effect size is depicted as a green square, with the size proportional to its weight in the meta-analysis. The black diamond represents the overall pooled estimate. Low heterogeneity (I2 = 0%) suggests consistency across studies. The overall effect (p < 0.00001) indicates a statistically significant benefit of massage.

3.2.3 Reflexology

Four clinical studies with a population size of 167 showed significant effectiveness in the management of cancer-related pain compared to usual care (SMD, −0.63; 95% CI, −1.71, −0.54; p < 0.001). Outcomes revealed no heterogeneity between studies (I2 = 0%). However, a sensitivity analysis was conducted to evaluate the impact of including data points from the Hodgson et al. study, as in this study combination intervention was employed. The analysis revealed no substantial differences in overall findings (effect size: −0.63, 95% CI: [−0.72, −0.55] vs. −0.63, 95% CI: [−0.71, −0.54]), confirming the robustness of the outcomes. The pooled effect size of the outcome measures revealed the significant effectiveness of reflexology in alleviating pain among patients with cancer (Figure 5).

Figure 5
Forest plot comparing aromatherapy versus control across four studies, with green squares representing individual study mean differences and 95% confidence intervals. The pooled mean difference is −0.67 with a 95% confidence interval of −0.98 to −0.36, indicating a statistically significant effect favoring aromatherapy. Chang et al. 2008 contributes the largest weight. Moderate heterogeneity is present with I2 at 42 percent. The overall effect, shown by a black diamond, lies to the left of the null line, supporting the efficacy of aromatherapy.

Figure 5. Forest plot showing the effect of reflexology on pain reduction compared to the control group. The X-axis represents the mean difference with a 95% confidence interval (CI), where negative values favor reflexology. Each study’s effect size is depicted as a green square, with the size proportional to its weight in the meta-analysis. The black diamond represents the overall pooled estimate. Low heterogeneity (I2 = 0%) suggests consistency across studies. The overall effect (p < 0.00001) indicates a statistically significant benefit of reflexology in pain alleviation.

3.2.4 Acupressure and acupuncture

Three RCTs out of 17 clinical studies with a population size of 183 patients showed statistically significant effectiveness of acupressure (Figure 6). Similarly, three RCTs out of 17 studies with a sample size of 237 demonstrated the effectiveness of acupuncture in managing cancer-related pain compared to the control group receiving usual care (SMD, −1.06; 95% CI, −1.28, −0.85; p < 0.001; I2 = 67%; SMD, −2.09; 95% CI, −2.92, −1.26; p < 0.001; I2 = 88% respectively). The outcomes revealed moderate to high between-study heterogeneity. The pooled effect size of the outcome measures indicated the significant effectiveness of both acupressure and acupuncture in alleviating pain in cancer patients (Figures 6, 7).

Figure 6
Forest plot illustrating the effect of acupuncture versus control across three studies, with individual mean differences and 95% confidence intervals represented by green squares. The pooled mean difference is −2.09 with a 95% confidence interval of −2.92 to −1.26, indicating a significant benefit of acupuncture. Bao et al. 2013 contributes the greatest weight. High heterogeneity is indicated by an I2 value of 88 percent. The overall effect, shown as a black diamond, is positioned left of the null line, favoring acupuncture.

Figure 6. Forest plot showing the effect of acupressure on pain alleviation compared to the control group. The X-axis represents the mean difference with a 95% confidence interval (CI), where negative values favor acupressure. Each study’s effect size is shown as a green square, with the black diamond representing the overall pooled estimate. High heterogeneity (I2 = 67%) suggests variability in study design, sample sizes or intervention protocols. The overall effect (p < 0.00001) indicates a statistically significant benefit of acupressure.

Figure 7
Risk of bias summary table showing methodological quality assessments for eighteen studies across nine bias domains. Each cell contains a color-coded symbol indicating risk: green plus for low risk, yellow question mark for unclear risk, and red minus for high risk. Most studies show a mix of low and unclear risk across domains, with high risk appearing most frequently in allocation concealment and blinding-related categories. Yeh et al. 2015 and Bao et al. 2013 display multiple high-risk assessments, while Jane et al. 2011 and Kim et al. 2008 show consistently low risk across all domains.

Figure 7. Forest plot showing the effect of acupuncture on pain alleviation compared to the control group. The X-axis represents the mean difference with a 95% confidence interval (CI), where negative values favor acupuncture. Each study’s effect size is shown as a green square, with the black diamond representing the overall pooled estimate. High heterogeneity (I2 = 88%) suggests variability in study design, sample sizes or intervention protocols. The overall effect (p < 0.00001) indicates a statistically significant benefit of acupuncture.

4 Discussion

Cancer is a multifactorial disease associated with severe pain that affects both the physical and psychological well-being of patients (16). Cancer-related pain is often severe and uncontrolled, disrupting the emotional health of cancer patients and leading to increased depression and anxiety and a decline in functional and social activities (17). Therefore, effective pain management strategies are required to improve the quality of life of cancer survivors (16). Pain management strategies, including pharmacological interventions, like medication and non-pharmacological interventions, such as aromatherapy and acupressure (18). Nurses play an important role in managing cancer-related pain by providing continuous assessment, administering pain relief interventions and providing non-pharmacological interventions to improve patients’ quality of life. Their holistic approach ensures personalized care and effective pain management strategies (19).

This comprehensive meta-analysis included 17 randomized controlled clinical trials to demonstrate the effectiveness of frequently employed non-pharmacological nursing strategies in alleviating pain associated with cancer. We targeted five often used non-pharmacological interventions for analysis, namely, aromatherapy, massage therapy, reflexology, acupressure and acupuncture. According to our findings, all five interventions were significantly more effective at alleviating pain among cancer patients than among those in the control group receiving only usual care (p < 0.001). While all interventions demonstrated statistically significant effectiveness in managing cancer-related pain, some analyses exhibited moderate to high heterogeneity. Massage therapy and reflexology provided the most reliable evidence, with significant effect sizes (SMD: −0.1 and −0.63 respectively) and no between-study heterogeneity (I2 = 0%), ensuring consistency and low risk of bias. Aromatherapy (SMD: −0.67; p < 0.001) showed moderate heterogeneity (I2 = 42%), indicating some variability across studies. However, acupressure and acupuncture demonstrated the strongest effect sizes (SMD: −1.06 and −2.09 respectively), but their high heterogeneity (I2 = 67% and 88%) suggests the methodological inconsistencies and potential variability among studies. These findings highlight the effects of study design, sample size and outcome measures on effect estimates. Despite statistical significance across interventions, the robustness of massage therapy and reflexology findings makes them the most reliable approaches for pain relief in cancer patients. Further large-scale, high-quality trials are needed to validate the findings and minimize uncertainty in interventions with high heterogeneity.

Our results revealed the positive effects of aromatherapy on the management of cancer-related pain. Similarly, numerous studies have shown that aromatherapy has therapeutic benefits in alleviating pain for cancer patients (2022). Similarly, consistent with our analysis, various investigational studies have revealed the effectiveness of reflexology (23), massage (24, 25), acupuncture (26, 27) and acupressure (28, 29) in alleviating pain associated with cancer.

However, some included studies reported insignificant outcomes, which may be attributed to various factors, including sample size, study design, intervention protocols and differences in patient populations. For instance, the RCTs on aromatherapy conducted by Wilkinson et al. (30) and Soden et al. (21) revealed a mild improvement in pain reduction, potentially due to variations in essential oil composition, duration of therapy or individual patient responses. Similarly, acupuncture trials, including Kim et al. (27) and Bao et al. (31) have reported insignificant outcomes, suggesting the possibility of a placebo effect or a need for refined methodologies in assessing acupuncture’s efficacy in pain management. These findings highlight the necessity for further large-scale, high-quality randomized controlled trials with standardized methodologies to confirm the effectiveness of non-pharmacological nursing interventions.

In 2011, a meta-analysis on the efficacy of acupuncture in the management of cancer-related pain was carried out by extracting data from three randomized clinical trials. Six databases were searched to extract relevant studies, and the outcomes revealed the effectiveness of acupuncture for pain alleviation among cancer patients (32). Similarly, a meta-analysis was carried out in 2011 to demonstrate the effectiveness of foot reflexology. The outcomes of that analysis revealed significant effectiveness in relieving pain and improving the quality of life in cancer patients (33).

The findings of our comprehensive meta-analysis suggest that non-pharmacological nursing strategies such as aromatherapy, massage therapy, reflexology, acupressure and acupuncture are significantly effective in alleviating cancer-related pain. The findings of our comprehensive meta-analysis suggest that non-pharmacological nursing strategies such as aromatherapy, massage therapy, reflexology, acupressure and acupuncture are significantly effective in alleviating cancer-related pain. However, moderate heterogeneity was observed due to the variation in sample sizes and outcome measures, the overall findings highlight the potential integration of these therapies into standard pain management protocols for cancer patients.

Our meta-analysis provides valuable new insights by providing evidence on the effectiveness of non-pharmacological nursing strategies for cancer-related pain management. By synthesizing data from multiple RCTs, this study strengthens the foundation for integrating these interventions into clinical practice. Despite the promising results, certain limitations must be acknowledged. The included studies exhibited variability in sample sizes and lacked subgroup analyses based on age, gender and type of cancer, which may affect the generalizability of our findings. Additionally, potential publication bias remains a concern, as studies with negative results are less likely to be published, potentially overestimating the effectiveness of these interventions. These factors necessitate the careful interpretation of the findings. To enhance the reliability of future research, standardized methodologies, diverse patient populations and long-term follow-ups should be prioritized. Further well-designed, large-scale RCTs are needed to validate these interventions and establish their sustained benefits in cancer pain management.

5 Conclusion

This meta-analysis highlights the effectiveness of non-pharmacological nursing strategies in alleviating cancer-related pain, offering valuable insights for clinical pain management. However, variations in sample sizes, intervention protocols and potential publication bias may impact generalizability. Future research should focus on large-scale, high-quality RCTs with standardized methodologies and diverse populations to confirm these findings. Integrating these non-pharmacological nursing interventions into standard care requires a balanced approach, ensuring both their proven effectiveness and practical feasibility within the healthcare system.

Data availability statement

The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author.

Author contributions

SY: Conceptualization, Formal analysis, Methodology, Writing – original draft. FY: Conceptualization, Formal analysis, Methodology, Writing – original draft. PL: Software, Validation, Writing – original draft. XF: Supervision, Writing – review & editing.

Funding

The author(s) declare that no financial support was received for the research and/or publication of this article.

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest.

Publisher's note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

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Keywords: aromatherapy, massage, cancer-related pain, reflexology, acupuncture, acupressure

Citation: Yan S, Yan F, Liangyu P and Fei X (2025) Assessment of non-pharmacological nursing strategies for pain management in tumor patients: a systematic review and meta-analysis. Front. Pain Res. 6:1447075. doi: 10.3389/fpain.2025.1447075

Received: 20 June 2024; Accepted: 31 March 2025;
Published: 15 April 2025.

Edited by:

Mery Paroli, Pisana University Hospital, Italy

Reviewed by:

Xiaodong Sheldon Liu, Beijing University of Chinese Medicine, China
Zachary Kohutek, Vanderbilt University Medical Center, United States

Copyright: © 2025 Yan, Yan, Liangyu and Fei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Xu Fei, ZHJ4ZmVpODhAb3V0bG9vay5jb20=

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.