ORIGINAL RESEARCH article
Front. Pain Res.
Sec. Musculoskeletal Pain
Volume 6 - 2025 | doi: 10.3389/fpain.2025.1532867
Rotating-Pulling-Poking Manipulation Effectively Alleviates Pain Symptoms of Lateral Ankle Sprain: An Animal Experimental Study
Provisionally accepted
- Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
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This study aimed to explore the analgesic mechanism of the Rotating -Pulling -Poking Manipulation in treating ALAS. Thirty rats were randomly divided into 5 groups in the first experiment to determine the dose -effect relationship by detecting ankle pain thresholds at different time points. The results showed that the 5 -minute manipulation group had the best analgesic effect, with the bipedal weightbearing difference decreasing over time and pain relief time shortened. In the second experiment, 30 rats were divided into 3 groups. After manipulation, samples from PAG and RVM were tested. The results indicated that compared with the model group, the 5 -minute manipulation group had increased MOR expression in PAG and 5 -HT concentration in cerebrospinal fluid, decreased expressions of BDNF, p -TrkB/TrkB in PAG and NR2A in RVM, and reduced contents of IL -6, IL -1β, TNF -α in ankle soft tissues. In conclusion, the Rotating -Pulling -Poking Manipulation can
Keywords: rotating-pulling-poking manipulation, ankle lateral sprain, analgesic mechanisms, biological effects, Animal experimental
Received: 25 Nov 2024; Accepted: 22 Apr 2025.
Copyright: © 2025 Wen, Jianguo, Fu, Feng, Li, Gao, Zhu and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Haibao Wen, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China
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