REVIEW article
Front. Pain Res.
Sec. Clinical Trials, Methods, and Evidence Synthesis
Volume 6 - 2025 | doi: 10.3389/fpain.2025.1576168
Development and refinement of the sore throat pain model as an assay for measuring therapeutic effects on acute pain
Provisionally accepted
- 1Schachtel Research Company Inc, Jupiter, United States
- 2School of Public Health, Yale University, New Haven, Connecticut, United States
- 3Reckitt Benckiser Healthcare International, Slough, United Kingdom
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The physical and subjective status of patients with acute throat pain has been developed and refined over the past 40 years as an acute pain model to measure changes in patient-reported symptoms attributed to active pharmacologic intervention when patients with painful pharyngitis are evaluated under randomized, double-blind, placebo-controlled conditions. Acute, painful pharyngitis is a familiar experience for the majority of adults and children ("a sore throat" is the most common example of the aches and pains of the common cold). As such, the condition has served as a general acute pain model to demonstrate the acute effects of non-prescription-strength analgesic agents (for mild-to-moderate pain) and prescription-strength analgesics (for moderate-to-severe pain). Here we discuss the methodologic features of this clinical pharmacology assay as it was refined from its original examinations of classic, orally administered, acute analgesics (aspirin, acetaminophen, aspirin with caffeine, ibuprofen) to its more recent evaluations of celecoxib, valdecoxib, topical benzydamine, and topical flurbiprofen.
Keywords: Acute Pain, sore throat, pain model, Pharyngitis, methodology, rating scales, treatment effects, symptoms. (Min. 5 -Max. 8)
Received: 13 Feb 2025; Accepted: 23 May 2025.
Copyright: © 2025 Schachtel and Shephard. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bernard Schachtel, Schachtel Research Company Inc, Jupiter, United States
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