MINI REVIEW article
Front. Pain Res.
Sec. Neuromodulatory Interventions
Volume 6 - 2025 | doi: 10.3389/fpain.2025.1607102
This article is part of the Research TopicNon-invasive Therapy for Pain ReliefView all 3 articles
The treatment of chemotherapy-induced peripheral neuropathy: a review of current management options and a potential role for scrambler therapy
Provisionally accepted
- University Hospitals Cleveland Medical Center, Cleveland, United States
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Chemotherapy-induced peripheral neuropathy (CIPN) presents a growing medical and financial burden on patients and the healthcare system alike. This has been treated with conservative and interventional care limited by efficacy, side effects, and lack of coverage. As such, there is an unmet treatment need for effective non-invasive or minimally invasive therapies for the treatment of CIPN. Scrambler therapy (ST) is a peripheral, non-invasive neuromodulation technique, which uses transcutaneous electrical stimulation to modulate pain signals. ST has shown mixed results in clinical trials; while some patients report symptom relief, more robust evidence is required before it can be widely recommended. This review article outlines the burden of CIPN and the current state of treatment, including pharmacological and interventional therapies. The emerging data on ST and its role in treating CIPN is highlighted, including a review of published observational and randomized controlled trials. We also discuss the gaps and challenges ahead in establishing this therapy as a standard of care.
Keywords: Cancer, Chemotherapy-induced peripheral neuropathy, Chronic Pain, neuropathic pain, Neuropathy, review, Scrambler therapy
Received: 07 Apr 2025; Accepted: 23 Jun 2025.
Copyright: © 2025 Aboumerhi, Vucetic, Gruenzel, Moftakhar, Gupta, Rao and Staudt. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Michael D Staudt, University Hospitals Cleveland Medical Center, Cleveland, United States
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