MINI REVIEW article
Front. Pain Res.
Sec. Pharmacological Treatment of Pain
Volume 6 - 2025 | doi: 10.3389/fpain.2025.1609095
This article is part of the Research TopicPain-Related Sleep Impairment: Expression, Mechanisms, and Treatment StrategiesView all articles
Widespread Pain Syndrome in Long COVID-19: Melatonin as an Adjuvant Treatment
Provisionally accepted
- 1University of Sousse, Sousse, Tunisia
- 2Prince Sultan University, Riyadh, Riyadh, Saudi Arabia
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Long coronavirus disease 2019 (LC19) represents a complex global health challenge. Survivors frequently report persistent problems like widespread pain syndrome (WPS), cognitive dysfunction, cardiovascular complications, and sleep disturbances. These health problems, which are worsened by oxidative stress and inflammaging, open the prospect of treatment strategies targeting these mechanisms. Melatonin is a potential option for treating LC19 problems because of its antiinflammatory, antioxidant, and pain-modulating properties. Melatonin targets shared pathological pathways, offering a promising approach to reducing inflammation, oxidative stress, and neuroendocrine dysfunction. The present mini-review explores the therapeutic potential of melatonin in the treatment of LC19, focusing on its effects on WPS and inflammation.
Keywords: Antioxidants, Chronic Pain, Inflammaging, long COVID-19, Melatonin, Oxidative Stress, widespread pain syndrome
Received: 09 Apr 2025; Accepted: 13 May 2025.
Copyright: © 2025 Souissi, Prieto-González and BEN SAAD. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Amine Souissi, University of Sousse, Sousse, Tunisia
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