REVIEW article
Front. Pain Res.
Sec. Neuropathic Pain
Volume 6 - 2025 | doi: 10.3389/fpain.2025.1642306
Innate Immunity in Chemotherapy-Induced Peripheral Neuropathy: Recent Advances
Provisionally accepted
Tongtong Lin1*
Nana Dong2- 1Nanjing University of Chinese Medicine, Nanjing, China
- 2Yantaishan Hospital - North Campus, Yantai, China
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Summary Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect in patients undergoing chemotherapy. Many commonly used chemotherapeutic agents simultaneously induce neurotoxicity and modulate the immune system. Emerging evidence highlights a critical role of the innate immune system in the development of various neuropathic pain conditions. As a natural immune defense mechanism formed during phylogenetic evolution, innate immunity elicits a robust response during CIPN pathogenesis. This review summarizes the roles of the innate immune system—including the skin barrier, innate immune cells, and innate immune molecules—in the context of CIPN.
Keywords: Chemotherapy-induced peripheral neuropathy, Innate immune system, Neurotoxicity, Quality life, macrophage
Received: 06 Jun 2025; Accepted: 08 Oct 2025.
Copyright: © 2025 Lin and Dong. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Tongtong Lin, 925703439@qq.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.