REVIEW article
Front. Pain Res.
Sec. Headache
This article is part of the Research TopicAdvances in Neuromodulation for Chronic Pain: Mechanisms and Clinical ImplicationsView all articles
The potential application of electrophysiological indicators in TMS treatment for MOH
Provisionally accepted
- 1Department of neurology, Peking University People's Hospital, Beijing, China
- 2Peking University People's Hospital, Beijing, China
- 3Peking University People's Hospital Department of Neurology, BEIJING, China
- 4Peking University Health Science Center, Beijing, China
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Medication Overuse Headache (MOH) can lead to central sensitization (CS), habituation deficits (HD), shortened cortical silent period duration (CSPD), and increased pre-activation levels (PAL), all of which are quantifiable electrophysiological objective indicators related to MOH. Transcranial magnetic stimulation (TMS) is a treatment method for MOH and is primarily divided into three types: single-pulse TMS (sTMS), repetitive TMS (rTMS), and quadruple-pulse TMS (qTMS). Among these, sTMS is convenient for patients of self-administration, qTMS significantly improves the effectiveness of TMS treatment, and rTMS is suitable for widespread use in developing countries. Numerous studies have reported clinical symptom improvements in MOH patients treated with TMS, with statistically significant results. However, only a few studies have observed electrophysiological changes in MOH patients before and after treatment. Whether quantifiable objective indicators can be reversed requires further investigation.
Keywords: Headache, Medicant overuse headache, Electrophysiological indicators, Transcranial Magnetic Stimulation, Treatment
Received: 21 Aug 2025; Accepted: 28 Oct 2025.
Copyright: © 2025 Hsiao, Han, Guo, Li, He, Ma and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hong Jiang, jh1991@sina.com
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