REVIEW article
Front. Pain Res.
Sec. Pain Mechanisms
Volume 6 - 2025 | doi: 10.3389/fpain.2025.1693399
Pain mechanism and management strategy of rheumatoid arthritis
Provisionally accepted
- Changzhou Municipal Hospital of Traditional Chinese Medicine, Changzhou, China
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Rheumatoid arthritis (RA) pain is one of the most common chronic pain in clinic. A large number of RA related literature have been reported. At present, although some analgesic measures are used in clinic, the pain management of patients after drug treatment is not ideal in real life, and clinically meaningful pain after treatment is still mentioned. RA pain is a complex pathological process, which involves inflammatory response, neuroimmune interaction, peripheral and central nerve sensitization, auto-antibodies, structural damage and other dimensions.Although inflammatory reaction is the most common cause of RA induced pain, neuroimmune interaction is the key and core of RA pain, and auto-antibodies are one of the significant characteristics of RA, which can directly or indirectly lead to pain.In addition, joint structural damage is the final pathological stage and serious consequence in the late stage of RA.This article aims to summarize the mechanism of RA pain, which is helpful to further clarify the diagnosis and provide targeted treatment.
Keywords: Pain, ra, Neuroimmune interaction, therapy, Inflammation
Received: 27 Aug 2025; Accepted: 30 Sep 2025.
Copyright: © 2025 Wang, Li, Wang, Ruan, Cai and Yan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaojing Yan, yanxiaojing963@njucm.edu.cn
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