Editorial on the Research TopicVisibility matters – women in neonatology By McGillick EV, Gizzi C, Volpe MA, Nakstad B, Kooi EMW, Wixey J, Tolcos M. (2022) Front. Pediatr. 10: 1059426. doi: 10.3389/fped.2022.1059426
We are delighted to present the inaugural Frontiers in Pediatrics Women in Neonatology series. Gender inequity in health and medical research has been perpetuated by long-standing biases (including unconscious bias), stereotypes and structural barriers to the recruitment, retention, career progression and recognition of women's achievements. While many structural changes are required to address these factors towards achieving equity, active allyship and visibility is also important to support and encourage the next generation of women and girls to pursue research careers. This article collection includes 5 original research papers, 2 brief research reports and 1 review article demonstrating a diversity of neonatology-related research led by women.
Depicolzuane et al. reviewed and presented a summary of animal and translational studies, and clinical observations on the role of lung surfactant protein A in lung function and importantly in lung protection from both infectious and non-infectious agents. Surfactant protein A has a unique role in the lung through its interactions with lung macrophages where it impacts the activity of alveolar macrophages in response to injurious agents or stimuli. Interestingly, surfactant protein A also has a role in control of the in utero environment.
In a mixed methods study, Eidger et al. investigated the perceptions of, and barriers to, effective teamwork within the multi-disciplinary context of neonatal resuscitation. The study explored the interconnected themes of team composition, hierarchy, leadership, communication and training. They highlighted the importance of team environments that value diversity of individuals training and experience, active leadership, effective communication, and modelling of supportive environments that enable all team members to feel comfortable speaking up.
In the neonatal intensive care unit (NICU), mothers are at risk of developing maternal distress and depression. Mautner et al. analyzed questionnaires on postnatal depression and resilience from mothers of term and preterm babies admitted to the NICU. The mothers with high resilience experienced significantly less depression compared to the mothers with low resilience scores. The authors suggest that evaluation of resilience should be included in standardized psychological follow-up enabling mothers to develop personalized strategies to cope with the distressing situation of having a child in the NICU. Further, social support from the partners, family members, friends and health care providers should be facilitated.
Preterm infants are at a higher risk of adverse neurodevelopmental outcomes than infants born at term. As an adverse fetal environment may play a key role in these outcomes, Van Dokkum et al. investigated potential underlying mechanisms of neurodevelopmental impairments using placental tissue. The study assessed whether placental DNA methylation of several genes affected early neurological functioning in preterm infants. In a cohort of 43 infants, the authors showed hypomethylation of NR3C1 (gene encoding for the glucocorticoid receptor) in placental tissue to be associated with poorer neurological outcomes at 3 months of age.
Helguera-Repetto et al. described infant seropositivity in the context of maternal SARS-CoV-2 infection and infant outcomes. This retrospective nested case-control study enrolled pregnant women with a positive SARS-CoV-2 RT-PCR test and their term infants. SARS-CoV-2 antibodies were present in 76% of neonates from seropositive mothers with a positive association between maternal IgG concentration and cycle threshold values with infant antibodies. Most neonates were asymptomatic, but 14% of seronegative neonates presented with respiratory disease compared to non-seropositive neonates. In addition, the odds of infant respiratory morbidity tended to decrease when infant IgG levels increased.
In a retrospective study, Mulot et al. reviewed infants <34 weeks gestation, hospitalized before 12 months due to a confirmed Respiratory Syncytial Virus (RSV)-related lower respiratory tract infection (LRTI). LRTI was considered very severe (VS-LRTI) when patients needed positive pressure ventilation. The main risk factor for VS-LRTI was a younger age corrected for prematurity at the onset of infection. Surprisingly, infants with VS-LRTI had higher gestational age and birthweight, a lower incidence of bronchopulmonary dysplasia and attended community childcare less often. Efforts to better understand risk factors associated with severity of RSV infections are necessary to elaborate early intervention strategies and monitoring plans.
In a preclinical study by Forbes et al., mRNA expression of TRPM6 and TRPM7, transmembrane cation channels thought to regulate intracellular cardiac calcium in the neonatal period, was examined in the preterm and term piglet heart; the effect of sex, antenatal glucocorticoids and the transition to postnatal life was also assessed. Increased TRPM7 mRNA in the piglet heart is a mature response to term birth, but is absent in preterm piglets, particularly those that did not receive antenatal glucocorticoids. Interestingly, TRMP7 mRNA was reduced in male preterm piglets. If this reduction limits myocardial calcium handling, this finding might contribute to the poorer outcomes for male preterm infants. The authors propose that targeting TRMP7 might improve cardiac function in preterm infants.
In a retrospective single centre study, Xodo et al. investigated how postnatal outcomes differ between preterm infants exposed to single dose or complete course of antenatal glucocorticoids. A complete course of antenatal glucocorticoids has significant clinical benefits for preterm infants including decreased respiratory morbidity and mortality, decreased neurological complications, improved maturation, and improved neurodevelopmental outcomes. Unfortunately, preterm infants often need to be delivered prior to a complete steroid course. This cohort showed that infants receiving one dose of antenatal glucocorticoids had an increased incidence of severe grades of intraventricular haemorrhage, periventricular leukomalacia, and worse respiratory course, conditions that impact neurodevelopmental outcome.
This article collection highlights work led by women in neonatology and their teams across 8 countries, including 64 authors spanning 39 clinical and research departments. It presents advances in theory, experiment, and methodology with applications to critical problems in neonatology, supporting healthcare teams and parents. In addition to presenting diverse research topics, it also demonstrates a breadth of diversity and intersectionality of the neonatology research community. As this Frontiers in Paediatrics series grows to support gender equity, we must continue to address inequities facing women, non-binary and gender diverse clinicians and researchers. Our community is richer and possibilities greater when we each actively advocate for and work towards equitable, diverse, and inclusive environments in the clinic, our research and teams.
Statements
Author contributions
All authors contributed to drafting of the editorial and approved final version for submission.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
neonatology, gender equity, diversity & inclusion, clinical, preclinical
Citation
McGillick EV, Gizzi C, Volpe M, Nakstad B, Kooi EMW, Wixey J and Tolcos M (2022) Editorial: Visibility matters – women in neonatology. Front. Pediatr. 10:1059426. doi: 10.3389/fped.2022.1059426
Received
01 October 2022
Accepted
10 October 2022
Published
07 November 2022
Volume
10 - 2022
Edited by
Dmitry Dukhovny, Oregon Health and Science University, United States
Updates
Copyright
© 2022 McGillick, Gizzi, Volpe, Nakstad, Kooi, Wixey and Tolcos.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Erin McGillick erin.mcgillick@unisa.edu.au
Specialty Section: This article was submitted to Neonatology, a section of the journal Frontiers in Pediatrics
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.