Abstract
Background:
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder that can manifest as thrombosis in the pediatric population, characterized by persistently positive antiphospholipid antibodies. APS is infrequently observed in children and could represent non-criteria manifestations.
Case presentation:
A six-year-old Chinese female presented with jaundice and dark urine, leading to a diagnosis of hemolytic anemia. Prednisone therapy initially improved her complexion, but she later developed neurological symptoms. Further laboratory tests showed intravascular hemolysis, coagulation abnormalities, and a positive lupus anticoagulant (LA) test result. Magnetic resonance imaging (MRI) scan revealed abnormal signals in the pons and cerebellar hemispheres, and an occluded part of the basilar artery. She was subsequently diagnosed with autoimmune encephalitis and received IG(immunoglobulin) and high-dose glucocorticoid (GC) treatment, leading to improvement in her clinical symptoms. However, the symptoms of hemolytic anemia worsened after two years. Subsequent laboratory assessments demonstrated the presence of intravascular hemolysis, coagulation abnormalities, and positive tests of anticardiolipin, LA, and anti-beta2 glycoprotein I antibodies. Elevated troponin I and N-terminal pro-brain natriuretic peptide levels, along with electrocardiogram and echocardiogram findings, indicated a myocardial infarction and a thrombus-like mass in the left auricle. Brain MRI showed multifocal infarction and cerebrovascular obstruction. She was diagnosed with APS accompanied by hemolytic anemia, cerebrovascular obstruction, and myocardial infarction. After several weeks of treatment with GC, IG, rituximab, hydroxychloroquine alone with low-molecular-weight heparin sodium, and warfarin, there was a marked improvement in the patient's condition.
Conclusion:
Pediatricians should be familiar with various presentations of pediatric APS to promptly detect possible aPL-related complications and initiate appropriate management strategies early on.
Background
Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by an increased risk of thrombosis or pregnancy complications. Currently, there is no universally accepted set of criteria for pediatric APS, so the classification criteria established for adult-onset APS are often utilized for pediatric patients as well. The updated Sapporo criteria, currently the most widely utilized standard, mandates the existence of at least one clinical event (confirmed thrombosis in arteries, veins, or small vessels and/or pregnancy-related morbidity) and at least one persistently positive antiphospholipid antibody (aPL) test [lupus anticoagulant (LA), anticardiolipin (aCL), or anti-beta2 glycoprotein 1(aB2GP1)] for a formal diagnosis of APS (1). However, given the absence of pregnancy in the pediatric population, APS can only be diagnosed in instances of thrombosis, whether unprovoked, minimally provoked, or atypical. It's important to highlight that risk factors such as cigarette smoking, atherosclerosis, hypertension, and hyperlipidemia are more prevalent among adults. Therefore, non-thrombotic clinical manifestations such as thrombocytopenia, hemolytic anemia, and neurological disorders often precede overt thrombosis in children with APS (2). This implies that applying diagnostic criteria designed for adult-onset APS to pediatric cases might lead to underdiagnosing or delayed diagnosis in children.
The American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR) have collaboratively formulated the classification criteria for APS in 2023, which offer more comprehensive coverage of clinical domains, expanding beyond the Sapporo criteria to encompass cardiac valve damage and thrombocytopenia. While these revised criteria may enhance the identification of pediatric APS, it is essential to note that their specificity and sensitivity for the pediatric demographic remain to be empirically validated (3). This is due to the potential divergence in atypical manifestations between the pediatric and adult populations, let alone pediatric APS seems to be more severe (4). Furthermore, the optimal treatment for arterial thrombotic complications in patients with APS has not yet been fully established. Evidence on the use of anticoagulation for thromboembolism is primarily inferred from adult practice, and data on INR ranges and dose adjustments for children are also extrapolated from adult practice (5). Hence, it is crucial to summarize the clinical manifestations and clinical practice experiences in pediatric patients.
Herein, we report a rare case of a six-year-old female Chinese patient with hemolytic anemia and accompanied cardiocerebral events, who was eventually diagnosed with APS at eight years of age.
Case presentation
In January 2021, a six-year-old Chinese girl with a yellowish tint to her skin and scleras and dark urine was diagnosed with hemolytic anemia. She had no past or family history of autoimmune diseases. Prednisone (PDN) treatment improved her complexion slightly, but her urine color remained dark. Later in June, she presented with paroxysmal vertigo several times a day, lasting for a few minutes per time. Ten days later, she exhibited unsteady walking, followed by slurred speech a few hours afterward, with occasional choking on liquids. She also experienced pain in her left toe and leg. A physical exam revealed red macules on her left foot and toe, and positive finger-nose and heel-to-toe tests. Bilateral Babinski signs were present.
Laboratory tests showed intravascular hemolysis with a negative direct Coombs test, significantly extended activated partial thromboplastin time (APTT), and a positive LA test result (Table 1). Magnetic resonance imaging (MRI) scan revealed abnormal signals in the pons and cerebellar hemispheres. Longitudinal relaxation time (T1) weighted imaging showed low signals and diffusion-weighted imaging showed partially high and isointense signals (Data not shown), transverse relaxation time(T2) weighted and fluid-attenuated inversion recovery (FLAIR) imaging showed high signals (Figure 1A). Magnetic resonance angiography (MRA) suggested part of the basilar artery was not visualized, which was considered a congenital variation at that time (Figures 1B,C). Based on these findings, the patient was diagnosed with autoimmune encephalitis. She received IG and methylprednisolone (mPDN) therapy (dose and duration of each treatment are detailed in Figure 2). Symptoms improved, and she was prescribed oral PDN (Figure 2). One month later, the MRI showed reduced inflammation (Data not shown). One year later in the second follow-up visit, laboratory tests were normal, except for a positive LA and slightly extended APTT (Table 1). The patient has not had any recurrence of symptoms in two years.
Table 1
| Variable | Normal range | First hospitalization | First follow-up visit | Second follow-up visit | Second hospitalization |
|---|---|---|---|---|---|
| 2021-06 | 2021-12 | 2022-06 | 2023-05 | ||
| APTT(S) | (28–42) | 77.8 | 84.1 | 67.2 | 79.5 |
| FIB(g/L) | (4–2) | 1.88 | NA | 2.94 | 6.16 |
| INR | (0.8–1.5) | 1.13 | NA | 0.93 | 1.23 |
| WBC(109 /L) | (4–10) | 8.70 | 12.31 | 9.80 | 14.69 |
| HB(g/L) | (120–165) | 108.0 | 136 | 113.0 | 48 |
| PLT(109 /L1) | (100–300) | 318 | 342 | 341 | 219 |
| TBIL(umol/L) | (2–22) | 35.8 | NA | NA | 107.2 |
| IBIL(umol/L) | (0–20) | 24.8 | NA | NA | 86.0 |
| ANA | <1:100 | NA | <1:100 | 1:320+ | |
| Coombs test | (−) | NA | NA | (+) | |
| Antiphospholipid antibodies | |||||
| aCLaIgM(MPL/ml) | (0–18) | 6.22 | NA | NA | 24.90 |
| aCLaIgG(GPL/ml) | (0–18) | 5.80 | NA | NA | 90.60 |
| LAb | (0–1.2) | 2.06 | 2.49 | 2.12 | 1.78 |
| aB2GP1c(RU/ml) | (0–20) | NA | 71.50 | NA | NA |
| aB2GP1aIgM(AU/ml) | (16–24) | NA | NA | NA | 156.00 |
| aB2GP1aIgG(AU/ml) | (16–24) | NA | NA | NA | 89.40 |
Laboratory findings.
APTT, activated partial thromboplastin time; FIB, fibrinogen; INR, international normalized ratio; WBC, white blood cell count; HB, hemoglobin; TBIL, total bilirubin; IBIL, indirect bilirubin; ANA, antinuclear antibody; PLT, platelet; LA, lupus anticoagulant; aCL, anticardiolipin; Ig, immunoglobulin; aB2GP1, anti-beta2 glycoprotein 1.
Detected by chemiluminescence immunoassay.
Detected through Russell viper venom time.
Detected via enzyme-linked immunosorbent assay.
Figure 1
Figure 2
Then the patient presented with a yellowish tint to her skin and scleras and tea-colored urine again. Subsequent laboratory assessments demonstrated elevated levels of troponin I of 2.240 μg/L (normal range: 0.00–0.02 μg/L) and N-terminal pro-brain natriuretic peptide of 5525 pg/ml (normal range: 0–115 pg/ml), along with a positive direct Coombs test. Additionally, laboratory findings indicated the presence of intravascular hemolysis, significantly extended APTT again, and a positive aPL test, encompassing aCL, LA, and aB2GP1 antibodies (Table 1). An electrocardiogram (ECG) showed sinus tachycardia and ST elevation in leads II, III, aVF, and V4–V6 (Figure 3A). A subsequent computed tomography angiography (CTA) test was conducted, revealing no evidence of embolism in the coronary arteries (Data not shown). Echocardiography (ECHO) revealed left ventricular wall motion abnormalities, a thrombus-like clot in the left auricle, decreased systolic function, and trace pericardial effusion (Figure 3B). MRI of the brain showed new abnormal signals in the right frontal and parietal lobes, with scattered signals in the brainstem and cerebellar hemispheres that had decreased in size. Compared to the previous MRA, the proximal part of the basilar artery was still not visualized, but the middle and distal segments were visualized, although were slender (Figures 1B,C). The original lesions in the cerebellum and pons have evolved into softening foci, indicating possible previous ischemic damage, suggestive of obstruction rather than congenital variation (Figure 1A).
Figure 3
The patient was diagnosed with APS accompanied by hemolytic anemia, cerebrovascular obstruction, and myocardial infarction (MI). After several weeks of treatment with glucocorticoid (GC), IG, rituximab (RTX), and hydroxychloroquine (HCQ) alone with simultaneous administration of warfarin and low-molecular-weight heparin sodium (Figure 2), the patient's skin and urine color returned to normal, indicating improvement in the condition. The ECG results demonstrated significant improvement, with only minor abnormalities in Q and T waves observed in leads II, III, aVF, and V5–V6, and ECHO confirmed the resolution of the blood clot (Data not shown). The patient's international normalized ratio (INR) was maintained within the target range of 2.0–3.0 (2), indicating effective anticoagulation therapy. The patient was discharged with a prescription for maintenance therapy with HCQ and PDN. Warfarin and low-molecular-weight heparin sodium were also prescribed to maintain the INR within the desired range. The patient is currently under close follow-up at the outpatient clinic and is well tolerated with the treatments according to the feedback.
Discussion and conclusions
The onset of APS during childhood can occur at any age, typically between the ages of 9 and 14. Although the prevalence of thrombosis among aPL-positive patients is generally lower than among adults, pediatric APS is almost always associated with thrombosis (6), which can manifest as venous thrombosis(60%), arterial thrombosis(32%), small vessel thrombosis (6%), or a combination of arterial and venous thrombosis (2%) (7). While the proportion of arterial thrombosis cases is relatively small, the risk of recurrence is higher compared to venous thrombosis cases of APS (2).
It is also important to note that non-thrombotic manifestations are more frequent in children and may even precede thrombotic manifestations (8, 9). A recent cohort study of aPL-positive children showed 90% did not develop any thrombotic event while hematological manifestations were the most frequent (42%), followed by neurological (19.8%) manifestations (10). Similar results were obtained in pediatric APS patients. Hematologic disorders were observed in 38% of patients, making them the most frequently associated non-thrombotic manifestation (7). Neurological manifestations such as ischemic stroke represent the most commonly observed arterial thrombotic event among children (9), even more so than in adults (7). However, some neurologic manifestations may also be attributed to immune-mediated vascular, inflammatory, and direct neuronal effects (11, 12). As shown in Table 2, symptoms like hemiparesis, and altered consciousness could be found in patients with or without evidence of occlusion of cerebral vessels.
Table 2
| Reference | Year | Demographic features | Scenario | Complications | Management/outcome |
|---|---|---|---|---|---|
| Nordal et al. (13) | 1999 | 12-year-old girl | Chorea, diffculty speaking. CT revealed decreased circulation in both basal ganglia and parts of the temporal lobes. | Primary APS | Anticoagulation, glucocorticoids, cyclophosphamide, azathioprine. |
| Shabana et al. (14) | 2009 | 9-year-old Saudi girl | Recurrent attacks of delirium with drooling of saliva. Depressive with abnormal behaviour, hallucinations, drowsiness, confusion and increased hours of sleep. | Primary APS | Aspirin, hydroycloroquine, and antidepressants. |
| Freeman et al. (15) | 2014 | Case 1: 13-year-old girl | Weakness right arm and leg, recurrent episodes of involuntary movements of right shoulder, arm and hand. Intermittent episodes of the sensation of burning or pain in fingers and toes. Extreme fatigue and occasional dizziness. | Secondary to SLE | Anticoagulant, hydroxychloroquine. glucocorticoids, hycophenolatemofeti. |
| Case 2: 9-year-old girl | Seizures (generalised tonic–clonic, left sided focal which secondarily generalised), left hemiparesis and slurred speech. | Primary APS | Anticoagulation therapy | ||
| Marzooq (16) | 2023 | 2-year-old girl | Sudden right-sided hemiparesis and altered consciousness. CT revealed a massive left middle cerebral artery ischemic stroke. | Primary APS | Anticoagulation and antiplatelet therapy |
| Qinghua et al. (17) | 2024 | 14-year-old girl | Cognitive impairment and chorea-like movements. MRI revealed a left-sided infarct in the midbrain. | Primary APS | Anticoagulation, glucocorticoids, intravenous immunoglobulin, and multiple plasma infusions. |
Pediatric APS with neurological manifestations.
CT, computed tomography; MRI, magnetic resonance imaging; SLE, systemic lupus erythematosus.
According to Lóczi et al., the majority of MI cases in APS patients initially manifest as MI, accounting for 73% of cases (2). These cases exhibit specific clinical characteristics, including a relatively young age at onset, absence of gender preponderance, predominantly without signs of atherosclerosis, and a heightened risk of recurrent thrombotic events. The literature on pediatric APS patients presenting with cardiac manifestations is scarce. Based on the limited number of pediatric case reports available (Table 3), the majority of cases involve primary APS, and there is no significant gender preponderance. It appears that MI in pediatric APS patients is more likely associated with thrombus formation in the coronary arteries as suggested in Table 3, although we have not found evidence of embolism in the coronary arteries in our case. The underlying pathophysiology of MI in APS is intricate and involves multiple factors. Other potential contributors to the development of MI include coronary spasm and spontaneous coronary dissection, apart from coronary thrombosis (2). Unlike our case where thrombosis was observed in the left atrium, two reported cases indicate thrombosis occurred in the right coronary artery, and one case in the left ventricle. The analysis may be prone to biases arising from the limited size of the available data. Therefore, it is imperative to acquire additional data, such as a larger cohort, to ensure a comprehensive and unbiased analysis of the clinical features.
Table 3
| Reference | Published year | Demographic features | Scenario | Complications | Management/outcome |
|---|---|---|---|---|---|
| Miller et al. (18) | 1995 | 8-year-old African-American girl | Transmural MI associated with thrombosis of coronary artery, small intramural arteries, and coronary arteriopathy. | Secondary to SLE | N/A |
| Clauss et al. (19) | 2003 | 2-year-old American boy | A history of cardiogenic shock, severe mitral and tricuspid regurgitation and recurrent thrombosis. | Primary APS | N/A |
| Al-Kiyumi et al. (20) | 2003 | 11-year-old Omani boy | Left ventricular thrombi and dilated cardiomyopathy. | Primary APS | Expired due to multiorgan failure. |
| Morchi et al. (21) | 2009 | 17-year-old boy | Acute MI associated with thrombus in the right coronary artery. | Primary APS | Eptifibatide, heparin, and aspirin for 48 h, then started on warfarin. |
| Moreno-Ruiz et al. (22) | 2010 | 14-year-old girl | MI (anterolateral and apical) | Primary APS | Warfarin, prednisone, and chloroquine |
| Waisayarat et al. (23) | 2019 | 12-year-old Thai boy | Thrombosis in the right atrium. | Primary APS | Expired from heart failure. |
| Yan et al. (24) | 2020 | 8-year-old Chinese girl | Thrombus in the right atrium. | Secondary to SLE, complicated with LN | Heparin for 2 weeks. Methylprednisolone for 3 days followed by oral steroids. |
Pediatric APS with cardiac manifestations.
SLE, systemic lupus erythematosus; LN, lupus nephritis; MI, myocardial infarction; N/A, not available.
There are some other limitations in our presentation, such as the lack of detailed profiles at the onset of the disease and no full scale of her past and family histories. However, upon retrospective analysis, the patient initially exhibited autoimmune hemolytic anemia, albeit with aberrant blood coagulation test results, an atypical presentation in hemolytic anemia, which prompted consideration of a potential aPL-related etiology, and aPL panel could be a valuable diagnostic tool. Subsequently, the patient developed symptoms such as paroxysmal vertigo, gait instability, and dysarthria, which are indicative of the diverse neurological manifestations that can accompany APS and therefore warranted a comprehensive neuroimaging evaluation, like CTA or MRA, to rule out the presence of ischemic stroke or thrombotic events. Additionally, routine ECG and ECHO may aid in detecting subtle myocardial infarction or cardiovascular thrombosis. A comprehensive autoimmune panel would be useful in identifying secondary APS.
In conclusion, pediatricians should be well-versed in the diverse presentations of pediatric APS to promptly identify potential aPL-related complications and implement appropriate management strategies early on. Non-criteria manifestations should be carefully considered, along with factors such as the patient's aPL profile and other thrombotic or bleeding risks.
Statements
Data availability statement
The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding authors.
Ethics statement
Written informed consent was obtained from the minor(s)' legal guardian/next of kin for the publication of any potentially identifiable images or data included in this article.
Author contributions
JZ: Writing – original draft, Conceptualization, Formal Analysis. Z-YW: Data curation, Writing – original draft. S-CL: Investigation, Writing – original draft. YW: Writing – review & editing, Validation. XF: Supervision, Writing – review & editing.
Funding
The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
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Summary
Keywords
antiphospholipid syndrome, hemolytic anemia, neurological manifestations, myocardial infarction, case report
Citation
Zheng J, Wei Z-Y, Lin S-C, Wang Y and Fang X (2024) Antiphospholipid syndrome onset with hemolytic anemia and accompanied cardiocerebral events: a case report. Front. Pediatr. 12:1370285. doi: 10.3389/fped.2024.1370285
Received
14 January 2024
Accepted
27 September 2024
Published
18 October 2024
Volume
12 - 2024
Edited by
Claudia Bracaglia, IRCCS Ospedale Pediatrico Bambino Gesù, Italy
Reviewed by
Rakesh Kumar Pilania, Post Graduate Institute of Medical Education and Research, India
Jiuliang Zhao, Peking Union Medical College Hospital (CAMS), China
Amira Ibrahim, Kafr El-Sheikh University, Egypt
Updates
Copyright
© 2024 Zheng, Wei, Lin, Wang and Fang.
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*Correspondence: Yong Wang wangyong0664@163.com Xin Fang fx7311@163.com
ORCID Jie Zheng orcid.org/0000-0002-1044-5527 Yong Wang orcid.org/0000-0001-7261-0391
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.