BRIEF RESEARCH REPORT article
Front. Pediatr.
Sec. General Pediatrics and Pediatric Emergency Care
Volume 13 - 2025 | doi: 10.3389/fped.2025.1518908
This article is part of the Research TopicNovel targets in pediatrics: advances in diagnostic and therapeutic approachesView all 9 articles
Identification of the key genes in children with sepsis by WGCNA in multiple GEO datasets
Provisionally accepted
- 1Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, China
- 2Wenzhou Medical University, Wenzhou, China
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Pediatric sepsis is a serious condition causing organ failure due to immune dysregulation, linked to high morbidity and mortality, highlighting the need for quick detection and treatment. This study aims to identify key genes involved in pediatric sepsis using three gene expression datasets from the Gene Expression Omnibus. We first identified differentially expressed genes (DEGs) with R, then conducted gene set enrichment analysis, and integrated DEGs with important module genes from weighted gene co-expression network analysis (WGCNA). We also screened adult sepsis datasets to find genes specific to pediatric cases, ultimately validating XCL1 as a key gene.This study suggests XCL1 is crucial in understanding pediatric sepsis etiology and its molecular mechanisms.
Keywords: Pediatric sepsis, WGCNA, GEO datasets, KEGG analysis, Molecular mechanisms
Received: 29 Oct 2024; Accepted: 28 Apr 2025.
Copyright: © 2025 Shen, Yu, Yu and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ze Yu, Wenzhou Medical University, Wenzhou, China
Xue Zhao, Zhejiang Chinese Medical University, Hangzhou, 310053, Zhejiang Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.