MINI REVIEW article
Front. Pediatr.
Sec. Pediatric Oncology
Lipid Metabolism Abnormalities in Pediatric Abdominal Solid Malignant Tumors: A Comprehensive Review
Provisionally accepted
- 1Yijishan Hospital of Wannan Medical College, Wuhu, China
- 2Wannan Medical College, Wuhu, China
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Pediatric abdominal solid tumors mainly include neuroblastoma, nephroblastoma, hepatoblastoma, and rhabdomyosarcoma. Although significant progress has been made in the treatment of these tumors with the combination of surgery and chemotherapy, the treatment outcomes for some patients remain unsatisfactory, and the mortality rate for late-stage patients is still high. The diagnosis and treatment of abdominal solid tumors remain one of the key challenges in pediatric oncology. Numerous studies have found that lipid metabolism abnormalities in tumor tissues and cells lead to a significant increase in lipid levels, promoting cell proliferation, tumor progression, and chemoresistance. This review focuses on the recent advances in the study of lipid metabolism abnormalities in pediatric abdominal solid tumors, aiming to provide a theoretical basis for the treatment of these tumors.
Keywords: Abdominal, Lipid Metabolism, pediatric, solid malignant tumor, Update
Received: 17 Oct 2025; Accepted: 03 Dec 2025.
Copyright: © 2025 Hao, Han, Mi, Hu, Lin and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Jie Liu
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