Your new experience awaits. Try the new design now and help us make it even better

SYSTEMATIC REVIEW article

Front. Pediatr.

Sec. Children and Health

Risks and benefits of face masks in children

Provisionally accepted
Kai  KisielinskiKai Kisielinski1*Claudia  Steigleder-SchweigerClaudia Steigleder-Schweiger2Susanne  WagnerSusanne Wagner3Stephan  KoruppStephan Korupp4Stefan  HockertzStefan Hockertz5Oliver  HirschOliver Hirsch6,7
  • 1Independent researcher, Smart medical solutions, scientific and technological services and research work, clinical medicine, orthopedic and trauma surgery, emergency medicine, social medicine, 40212 Düsseldorf, Germany
  • 2Department of Paediatrics, University Hospital of Salzburg, Paracelsus Medical University, 5020 Salzburg, Austria
  • 3Non-clinical expert, veterinary medicine, Wagner MSL Management, 15831 Mahlow, Germany
  • 4Surgeon, Emergency Medicine, Private Practice, 52070 Aachen, Germany
  • 5tpi consult AG, Haldenstr. 1, CH 6340 Baar, Switzerland
  • 6FOM Hochschulzentrum Siegen, Siegen, Germany
  • 7Department of Psychology, FOM University of Applied Sciences, 57078 Siegen, Germany

The final, formatted version of the article will be published soon.

Introduction: Children, a significant and vulnerable portion of the global population, are particularly susceptible to environmental factors. Methods: We conducted a systematic search and scoping review of 3,144 articles, including 107 publications from medical literature, to assess mask use in children during the 2020–2023 pandemic. We examined expected viral protection versus scientific evidence and side effects, synthesising findings with SWiM and GRADE frameworks for evidence certainty and the Cochrane adverse effects approach. Results: Masking children lacks ecological validity, with high-quality studies showing little real-world effectiveness against viruses. On the other hand, side effects can clearly be identified. Masks contain hazardous materials (carcinogens, heavy metals, organic compounds, microplastic), impacting children´s health by altering inhaled air (including elevated carbon dioxide) and causing many physical symptoms and bio-psychosocial issues (MIES syndrome), akin to sick building syndrome. Toxicological assessments highlight risks to biology of the young. Evidence certainty is high for non-effectiveness, moderate for risks and side effects, and low to very low for viral protection or benefits in children. Conclusions: With a negligible COVID-19 mortality rate in children (0.0003%) and no evidence of child-to-child or school-based transmission, masks offered little benefit during the pandemic. The documented adverse effects — respiratory impairment, toxicity, and health risks — outweigh any justification for their mandatory use. An individual risk-benefit analysis is essential (individual medical advice), but this review suggests avoiding this intervention in children due to its numerous downsides and lack of proven efficacy. It is the responsibility of political leaders to address our findings.

Keywords: adverse effects, Children, health risk assessment, Long-term adverse effects, Masks, MIES syndrome, N95, risk

Received: 04 Aug 2025; Accepted: 21 Jan 2026.

Copyright: © 2026 Kisielinski, Steigleder-Schweiger, Wagner, Korupp, Hockertz and Hirsch. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Kai Kisielinski

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.