REVIEW article
Front. Pediatr.
Sec. Pediatric Immunology
This article is part of the Research TopicAdvances and Challenges in Pediatric Immune Disorders: From Pathogenesis to Personalized TherapyView all 7 articles
Progress of biological agents and CAR cell therapy in the treatment of common autoimmune diseases in children
Provisionally accepted
- 1Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, China
- 2Rainbow Hospital of Xianyang, Xianyang,Shaanxi Province, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Autoimmune diseases are characterized by immune disorders that lead to abnormal activation of autoreactive immune cells, which in turn lead to tissue destruction and organ dysfunction. Compared with adults, autoimmune diseases in children are more severe, with increased disease activity and organ damage occurring earlier, and with higher mortality. In addition to the poor effect of traditional therapy in some children, children also have the needs for growth and development, and the use of traditional therapy will lead to severe immunosuppression and sequelae, affecting the quality of life of children. The emergence of Chimeric antigen receptors (CAR) cell therapy and biological agents has provided new treatment options for children with autoimmune diseases.
Keywords: Autoimmune Diseases, Biological Agents, car cell therapy, Children, Immunomodulatory agents
Received: 09 Nov 2025; Accepted: 09 Feb 2026.
Copyright: © 2026 Yin, Zhang, Liu, Gao, Wang and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wei-Hua Zhang
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.