ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Neonatology
Observation of the blood pressure changes in preterm infants with gestational age of 28 to <37 weeks within 7 days after birth:a single center retrospective study
Provisionally accepted
- Jinan Children's Hospital, Jinan, China
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Objective: To investigate the blood pressure change pattern in preterm infants (28 to <37 weeks of gestation) within 7 postnatal days. Methods: A retrospective analysis was performed on preterm infants admitted to our neonatal department from January 2022 to January 2025, who underwent non-invasive blood pressure monitoring and received no hypotension intervention. We collected demographic data of infants and their mothers, postnatal 7-day blood pressure readings, clinical outcomes and complications. Blood pressure trends were analyzed to support the establishment of gestational age-specific blood pressure reference intervals. Results: A total of 191 eligible preterm infants were enrolled. Systolic blood pressure (SBP) and mean arterial pressure (MAP) increased significantly within 7 days (P<0.001). SBP differed significantly between postnatal day 1 vs days 3–7, and day 2 vs day 6. MAP differed significantly between day 1 vs days 5–6, and day 2 vs day 6. No significant differences were found in other pairwise comparisons. Diastolic blood pressure (DBP) showed no obvious trend within one week. Conclusion: SBP and MAP rise spontaneously with postnatal age in 28 to <37 weeks preterm infants within 7 days, with SBP increasing more markedly and stabilizing after day 3. Gestational age-specific blood pressure references can support early blood pressure evaluation and clinical management for preterm infants.
Keywords: Blood preasure, First 7 days after birth, Gestational age of 28 to <37 weeks, preterm infants, Regularity of blood pressure changes
Received: 30 Nov 2025; Accepted: 16 Feb 2026.
Copyright: © 2026 Guan and Yu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Peiru Yu
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