CASE REPORT article
Front. Pediatr.
Sec. Pediatric Endocrinology
Tamoxifen Therapy in Juvenile Gigantomastia Associated with PASH: A Case Report
Simone Coslovich 1
Marina Bortul 2
Fabrizio Zanconati 2
Gianluca Tornese 1,2
1. IRCCS materno infantile Burlo Garofolo Biblioteca Scientifica, Trieste, Italy
2. Universita degli Studi di Trieste, Trieste, Italy
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Abstract
Pseudoangiomatous stromal hyperplasia (PASH) is a rare benign breast lesion in children. We report a 10-year-old girl with hormonally driven gigantomastia and recurrent mastitis, interpreted as a secondary inflammatory complication of rapid breast enlargement. Treatment with oral tamoxifen led to arrest of breast growth and resolution of inflammatory symptoms. This case supports tamoxifen as a potential non-surgical option for hormonally driven pediatric gigantomastia associated with PASH.
Summary
Keywords
breast volume reduction, Gigantomastia, Non-surgical management, PASH, pediatric breast mass, Tamoxifen
Received
11 December 2025
Accepted
17 February 2026
Copyright
© 2026 Coslovich, Bortul, Zanconati and Tornese. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Simone Coslovich
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