ORIGINAL RESEARCH article
Front. Pediatr.
Sec. Pediatric Neurology
Clinical Application of Regional Cerebral Oxygen Saturation with Disturbance Coefficient in Children with Brain Functional Injury
Shuai Liu
Lihong Hu
Meixian Xu
Xin Zhao
Zexi Wang
Hebei Children's Hospital, Shijiazhuang, China
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Abstract
To exploring the clinical value of monitoring cerebral oxygen saturation and disturbance coefficient in children with brain injury.Methods:This study enrolled 92 children with brain dysfunction from March 2024 to May 2025 as the research group. They were divided into three subgroups based on age: 1-3 years old, 3-6 years old, and 6-16 years old. During the same period,150 children who underwent outpatient health examinations were selected as the control group.General information (age, gender, etc.) was collected for both groups. Within 24 hours of admission, the research group monitored and recorded DC and rSO2 using non-invasive brain edema and cerebral oxygen saturation monitors, while the control group was monitored DC and rSO2 during outpatient visits.This study aims to compare different DC and rSO₂ groups, examine their correlation with GCS scores, and evaluate the utility of DC and rSO₂ in assessing clinical status and predicting prognosis in children with brain injury. Results:There was no statistically significant difference in age and gender between the two groups of patients (P>0.05). The DC and rSO2 levels in the research group were lower than those in the control group, and the difference was statistically significant (P<0.05). There was no statistically significant difference (P>0.05) in DC and rSO2 levels among children of different genders and etiologies in the research group. There is a positive correlation between DC, rSO2, and GCS scores in the research group, indicating that the more severe the brain injury, the lower the DC and rSO2 levels. In the 3-6 year old group of children, DC may be useful in identifying children at risk for cerebral edema, with an area under the curve of 0.834. The optimal cutoff value for DC is 75, with a sensitivity of 75% and a specificity of 78.6%.rSO2 was associated with poor clinical outcomes, with an area under the curve of 0.765, an optimal cut-off point of 73.5%, a sensitivity of 70.7%, and a specificity of 83.3%.Conclusion:DC and rSO2 may provide complementary information in the evaluation of the condition and prognosis of children with brain injury, as they are non-invasive, dynamic, and have a wider range of clinical applications.
Summary
Keywords
cerebral edema, Childhood brain injury, Disturbance coefficient, Monitoring of cerebral oxygen saturation, Non invasive monitoring
Received
16 January 2026
Accepted
20 February 2026
Copyright
© 2026 Liu, Hu, Xu, Zhao and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Zexi Wang
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