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Original Research

Published on 18 Oct 2021

Mechanistic Modeling of Placental Drug Transfer in Humans: How Do Differences in Maternal/Fetal Fraction of Unbound Drug and Placental Influx/Efflux Transfer Rates Affect Fetal Pharmacokinetics?

in Obstetric and Pediatric Pharmacology

  • Xiaomei I. Liu
  • Dionna J. Green
  • John N. van den Anker
  • Natella Y. Rakhmanina
  • Homa K. Ahmadzia
  • Jeremiah D. Momper
  • Kyunghun Park
  • Gilbert J. Burckart
  • André Dallmann
Mechanistic Modeling of Placental Drug Transfer in Humans: How Do Differences in Maternal/Fetal Fraction of Unbound Drug and Placental Influx/Efflux Transfer Rates Affect Fetal Pharmacokinetics?
Frontiers in Pediatrics
doi 10.3389/fped.2021.723006
  • 4,687 views
  • 7 citations