Frontiers in Pharmacology

Editorial

Published on 13 Jun 2025

Editorial: Multi-target drug discovery and design for complex health disorders

in Experimental Pharmacology and Drug Discovery

Farid A. Badria
Barbara De Filippis
Mohammed Abu El-Magd
Mostafa M. Elbadawi
Abdelrahman Hamdi
Abdullah A. Elgazar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1633600

237 views

Review

Published on 13 Jun 2025

Advances and challenges in cancer immunotherapy: mechanisms, clinical applications, and future directions

in Translational Pharmacology

Neeharika Vatsavai
Sumeet Kaur Bhinder
Rahaman Shaik
Shaheen Mahira
Shruti Kapoor
Md Shadab Ali
Deepak Verma
Jay Singh
Sreelakshmi Badavenkatappa Gari
Prabhat Upadhyay

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1602529

635 views

Original Research

Published on 13 Jun 2025

AduCPI2 alleviates MSU-induced acute gouty arthritis in mice by inhibiting cathepsin S and the C5a-C5aR1 axis

in Inflammation Pharmacology

Sijing Liu
Yongli Situ
Li Deng
Meng Liang
Haoyuan He
Zheng Shao
Lifei Peng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1604329

251 views

Systematic Review

Published on 13 Jun 2025

Efficacy and safety of Danhong injection on inflammatory factors and vascular endothelial function in patients with unstable angina pectoris: a systematic review and meta-analysis of randomized clinical trials

in Ethnopharmacology

Zunqi Kan
Wenli Yan
Cong Chen
Huanyu Gao
Yongmei Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1389746

195 views

Original Research

Published on 13 Jun 2025

Clinical features and genetic spectrum of children with primary ciliary dyskinesia in central China: a referral center retrospective analysis

in Respiratory Pharmacology

Xiaoning Zhang
Xiuhong Jin
Zhiying Zhang
Yanqiong Wang
Xiangfeng Zhang
Zhen Dong
Haiming Yang
Yuelin Shen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1526675

306 views

Systematic Review

Published on 13 Jun 2025

Efficacy of Xiaoyao-san preparations in treating Hashimoto’s thyroiditis: a meta-analysis and systematic review

in Ethnopharmacology

Chengna Wang
Wenxin Ma
Lingling Qin
Lili Wu
Tonghua Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1528506

276 views

Original Research

Published on 13 Jun 2025

The anti-depressive role of the Pei Yuan Kai Yu formula in cerebral small vessel disease based on gut microbiota

in Experimental Pharmacology and Drug Discovery

Lixuan Yang
Yutian Ao
Yannan Li
Baoan Dai
Junnan Li
Wenzhe Duan
Kaiqiang Dong
Zhenyun Han
Rongjuan Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1510250

211 views

Review

Published on 13 Jun 2025

Lactate-induced lactylation: from basic research to clinical perspectives

in Experimental Pharmacology and Drug Discovery

Henghe Shi
Yifei Zou
Sijie Jin
Junduo Wu
Bin Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586973

248 views

Original Research

Published on 13 Jun 2025

Therapeutic drug monitoring of voriconazole and the impact of inflammation on plasma trough concentrations in children

in Obstetric and Pediatric Pharmacology

Lin Hu
Changyu Wang
Xi Tang
Qi Huang
Yanfei Li
Shiqiong Huang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1575233

220 views

Review

Published on 13 Jun 2025

Guarding minds: a narrative review on how n-acetylcyteine and ketones could shield sensitive patients from antibiotic neurotoxicity

in Neuropharmacology

Astrid Lounici

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1613152

283 views

Original Research

Published on 13 Jun 2025

Integrating Drosophila and Vibrio fischeri models for toxicity evaluation: uncovering detoxification trends in psoralea Fructus-TCM formulations

in Ethnopharmacology

Cheng Zhang
Yina Li
Fangyang Li
Wanyun Dang
Zhuo Shi
Chunqi Yang
Chengrong Xiao
Xianglin Tang
Yuguang Wang
Yue Gao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1590929

252 views

Original Research

Published on 13 Jun 2025

Identification of an Ara-C resistance-related gene risk score and the role of S100A4 in AML via NR6A1-dependent activation and p53 regulation

in Pharmacology of Anti-Cancer Drugs

Li Wang
Aoshuang Huang
Bingqing Cheng
Xiuying Hu
Jishi Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1574759

332 views

Systematic Review

Published on 13 Jun 2025

Efficacy and safety of Rhodiola crenulata extract in the treatment of acute high altitude disease, based on studies involving populations in China: A systematic review and meta-analysis

in Ethnopharmacology

Zixuan Gao
Yaoyuan Liu
Weiwen Liao
Wenting Song
Xinyi Zhang
Hanqing Lin
Han Zhang
Tao Zhang
Wentai Pang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1595953

345 views

Original Research

Published on 13 Jun 2025

Hsa_circ_0002238 promotes the malignant behavior of colorectal cancer

in Pharmacogenetics and Pharmacogenomics

Lin-Ting Zhang
Yuejia Zhou
Tiantian Wang
Boran Chen
Zhigao Cai
Shubin Wang
Gangling Tong

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541820

215 views

Original Research

Published on 13 Jun 2025

Mechanistic Insights and Anti-cancer Activity of 2H-benzo[b][1,4]oxazin-3(4H)-one Linked 1,2,3-Triazoles in Human Cancer Cells

in Pharmacology of Anti-Cancer Drugs

Qingying Liu
Xixi Hou
Mingyue Tian
Baoyu He
Jingjing Guo
Yajie Guo
Jianxue Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565657

285 views

Original Research

Published on 13 Jun 2025

Molecular mechanisms of polychlorinated biphenyls in breast cancer: insights from network toxicology and molecular docking approaches

in Predictive Toxicology

Xiaoyu Yang
Wenlong Liang
Zhenchu Feng
Guangyan Li
Xi Chen
Jianguo Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1604993

289 views