Frontiers in Pharmacology

Original Research

Published on 11 Feb 2026

Impaired adenosine pathways in HFpEF: insights into cardiorenal alterations and endothelial responses

in Cardiovascular and Smooth Muscle Pharmacology

Maria Antonietta Riemma
Gennaro Madonna
Elena Mele
Elena Conte
Marialucia Telesca
Giacomo De Palma
Barbara Kutryb-Zając
Carla Cicala
Paola Imbrici
Antonella Liantonio

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1720123

358 views

Original Research

Published on 11 Feb 2026

Multitarget mechanisms of the herb pair Achyranthes bidentata and Paeonia lactiflora Pall. in ameliorating hypertensive cardiomyopathy: combining network pharmacology and functional exploration

in Cardiovascular and Smooth Muscle Pharmacology

Yanyan Zhang
Yingwanqi Wang
Jianing Liu
Yu Zhao
Yuhui He
Peimei Yan
Shan Ren
Ying Lyu
Weiwei Jia
Yuran Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1717533

329 views

Original Research

Published on 11 Feb 2026

A retrospective clinical analysis of inappropriate Xiangdan Injection use: clinical risk profiling and computational hypothesis generation

in Ethnopharmacology

Ji Zeng
Yougang Wei
Jinke Zhang
Yiming Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1742792

404 views

Review

Accepted on 10 Feb 2026

Inconsistent medication recommendations for immune-mediated inflammatory diseases across pregnancy, lactation, and paternal preconception: a guideline-based review

in Obstetric and Pediatric Pharmacology

Elise Van den Broeck
Sien Lenie
Marc Ferrante
Ellen De Langhe
Barbara Neerinckx
Tom Hillary
Kristel Van Calsteren
Anne Smits
Laure Sillis
Mette Julsgaard

Frontiers in Pharmacology

Review

Accepted on 10 Feb 2026

Epidemiological relevant effect biomarkers for thyroid hormone system related adverse outcome pathways: a literature review

in Predictive Toxicology

Maria Wielsøe
Manhai Long
Antonios K. Stratidakis
Elisavet Renieri
Dimosthenis Sarigiannis
Eva Cecilie Bonefeld-Jørgensen

Frontiers in Pharmacology

Original Research

Accepted on 10 Feb 2026

Hydrochlorothiazide and Chlorthalidone Use and Glaucoma Risk: Pharmacovigilance Analysis and Nationwide Cohort Study

in Pharmacoepidemiology

Jooyoung Yoon
Jiyeong Kim
Ko Eun Kim
Jee-Eun Chung
Seong Joon Ahn

Frontiers in Pharmacology

216 views

Original Research

Accepted on 10 Feb 2026

Comprehensive dose-dependent hepatorenal protective effects of Ziziphus nummularia leaf extract against Quinolphos-induced toxicity in Wistar rats

in Ethnopharmacology

Ramya Rengaraj
Stalin Arumugam
Praveen Kumar Dharmaraj
Varadharajan Gokula
Aarthi Murugavel
Mohamed Saiyad Musthafa
Cristiana Roberta Multisanti
Caterina Faggio

Frontiers in Pharmacology

Original Research

Accepted on 10 Feb 2026

Antifungal and anti-virulence activities of cinnamon, thyme, and clove essential oils against Candida species

in Pharmacology of Infectious Diseases

Toni Gabaldón
Islam Ahaik
Juan Carlos Nunez-Rodríguez
Sònia Abelló-Cros
Oscar Yanes
Samira Bouhdid

Frontiers in Pharmacology

106 views

Original Research

Accepted on 10 Feb 2026

Efficacy and safety of camrelizumab-based regimens in advanced squamous cell carcinoma patients: a prospective multicenter study

in Translational Pharmacology

Weijia Jiang
Wanren Peng
Dong Qian
Genhe Wang
Hong Qian
Wenxia Deng
Zishu Wang
Zhiyong Wei
Tai Ma
Dong Zhao

Frontiers in Pharmacology

Original Research

Accepted on 10 Feb 2026

Anjiang Formula Inhibits PVN Microglial Activation and Lowers Blood Pressure by Targeting RhoA/ROCK2 Pathway: A Retrospective Clinical and Experimental Study

in Ethnopharmacology

Xuanjing Chen
Jun Chen
Zhenglin Chen
Dwei Lian
Jing Wang
Jin Luo
Meizu Wu
Aling Shen
Lianfa Chen

Frontiers in Pharmacology

Original Research

Accepted on 10 Feb 2026

Risk Assessment of Drug-Associated Miscarriage Using XGBoost and SHAP Explainability: A Real-World Pharmacovigilance Analysis Based on the FAERS Database

in Pharmacoepidemiology

Sen Lin
Lanyue Ma
Ruiqi Zhao
Lisheng Peng
Xinyu Zhang
Bei Zhang
Danfei Li
Yijia Li
Li He

Frontiers in Pharmacology

Review

Accepted on 10 Feb 2026

Systems-Level Actions of Luteolin in Female Reproductive Disorders: From Molecular Mechanisms to Clinical Translation

in Translational Pharmacology

Lenah Saeed Binmahfouz

Frontiers in Pharmacology

Correction

Accepted on 10 Feb 2026

Correction: The night is dark and full of hesitation. The latest step in the legal trajectory of assisted suicide in Italy: through tentative judicial openings, bioethical contradictions and the Parliament's deafness

in Drugs Outcomes Research and Policies

Frontiers Production Office

Frontiers in Pharmacology

Original Research

Published on 10 Feb 2026

Immunosuppressant treatment reduces cocaine-induced behavioral sensitization in mice

in Neuropharmacology

Gabriella Luciana de Oliveira
Maria Carolina Machado da Silva
Giovanni Freitas Gomes
Roberta dos Santos Ribeiro
Gabriela Reis Cussat
Rúbia Aparecida Fernandes
Jorge Lucas Nascimento Souza
Heliana de Barros Fernandes
Aline Silva de Miranda
Victor Rodrigues Santos

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1757023

519 views

Review

Published on 10 Feb 2026

Cellular strategies for repairing trapped protein-DNA complexes

in Pharmacogenetics and Pharmacogenomics

Maria Sideridou
Doukissa Ioanna Machli
Dora Lontra
Theodoros Rampias

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1716415

305 views

Original Research

Published on 10 Feb 2026

A comparative study on the efficacy and safety of biosimilar (Rimmyrah) and reference ranibizumab in patients with diabetic macular edema

in Drugs Outcomes Research and Policies

Gaixia Zhai
Xiaona Ren
Bing Xu
Dongming Mi

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1773081

354 views

Original Research

Published on 10 Feb 2026

Impact of non-steroidal anti-inflammatory drugs on malignant transformation in oral lichen planus: insights from a real-world cohort study

in Pharmacoepidemiology

Christian Seebauer
Ralf Ludwig
Peter Sieg
Henning Olbrich
Philip Curman

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1752108

311 views

Review

Published on 10 Feb 2026

Alternative methods for pharmacological research on the action mechanisms of natural products used in the treatment of type 2 diabetes: a systematic review

in Ethnopharmacology

Fernanda Artemisa Espinoza-Hernández
Samantha Martínez-Medina
Gerardo Mata-Torres
Christian Alan Cabello-Hernández
Adolfo Andrade-Cetto

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1729030

514 views

Original Research

Published on 10 Feb 2026

Historical studies on the use of Rhubarb in Japan

in Ethnopharmacology

Misato Ota
Toshiaki Makino

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1726521

531 views

Case Report

Published on 10 Feb 2026

Clopidogrel-induced drug-induced hypersensitivity syndrome following percutaneous coronary intervention: a case report of therapeutic dilemma and management strategy

in Cardiovascular and Smooth Muscle Pharmacology

Sikun Wang
Jiang Zhou
Yuanhua Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1695177

586 views

Editorial

Published on 10 Feb 2026

Editorial: Digital health innovations in Africa: harnessing AI, telemedicine, and personalized medicine for improved healthcare

in Drugs Outcomes Research and Policies

Rohan M. Benecke
Innocent G. Asiimwe
Ahmed A. Abulfathi
Samer Mouksassi
Bernd Rosenkranz

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1799832

293 views

Original Research

Published on 10 Feb 2026

Licochalcone B suppresses oxidative stress and apoptosis accompanied by upregulating Nrf2/HO-1 pathway to ameliorate diabetic nephropathy in mice

in Experimental Pharmacology and Drug Discovery

Shan Luo
Yake Lan
Ruoqi Zhang
Zhongqiu Luan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1737091

404 views

Original Research

Published on 10 Feb 2026

Evaluating a multifaceted stewardship intervention on proton pump inhibitor utilization: an interrupted time-series analysis of prescribing patterns in a northwest Chinese hospital

in Drugs Outcomes Research and Policies

Xiaoling Wang
David J. McIver
Hui Min
Jia Guo
Haiyan Li

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1700146

328 views

Brief Research Report

Published on 10 Feb 2026

Sphingosine-1-phosphate receptor signaling regulates an ERK1/2–p65 molecular switch in macrophages during Leishmania donovani infection

in Pharmacology of Infectious Diseases

Mohd Arish
Farha Naz

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1769137

277 views

29,505 articles

articles

Impaired adenosine pathways in HFpEF: insights into cardiorenal alterations and endothelial responses

Multitarget mechanisms of the herb pair Achyranthes bidentata and Paeonia lactiflora Pall. in ameliorating hypertensive cardiomyopathy: combining network pharmacology and functional exploration

A retrospective clinical analysis of inappropriate Xiangdan Injection use: clinical risk profiling and computational hypothesis generation

Inconsistent medication recommendations for immune-mediated inflammatory diseases across pregnancy, lactation, and paternal preconception: a guideline-based review

Epidemiological relevant effect biomarkers for thyroid hormone system related adverse outcome pathways: a literature review

Hydrochlorothiazide and Chlorthalidone Use and Glaucoma Risk: Pharmacovigilance Analysis and Nationwide Cohort Study

Comprehensive dose-dependent hepatorenal protective effects of Ziziphus nummularia leaf extract against Quinolphos-induced toxicity in Wistar rats

Antifungal and anti-virulence activities of cinnamon, thyme, and clove essential oils against Candida species

Efficacy and safety of camrelizumab-based regimens in advanced squamous cell carcinoma patients: a prospective multicenter study

Anjiang Formula Inhibits PVN Microglial Activation and Lowers Blood Pressure by Targeting RhoA/ROCK2 Pathway: A Retrospective Clinical and Experimental Study

Risk Assessment of Drug-Associated Miscarriage Using XGBoost and SHAP Explainability: A Real-World Pharmacovigilance Analysis Based on the FAERS Database

Systems-Level Actions of Luteolin in Female Reproductive Disorders: From Molecular Mechanisms to Clinical Translation

Correction: The night is dark and full of hesitation. The latest step in the legal trajectory of assisted suicide in Italy: through tentative judicial openings, bioethical contradictions and the Parliament's deafness

Immunosuppressant treatment reduces cocaine-induced behavioral sensitization in mice

Cellular strategies for repairing trapped protein-DNA complexes

A comparative study on the efficacy and safety of biosimilar (Rimmyrah) and reference ranibizumab in patients with diabetic macular edema

Impact of non-steroidal anti-inflammatory drugs on malignant transformation in oral lichen planus: insights from a real-world cohort study

Alternative methods for pharmacological research on the action mechanisms of natural products used in the treatment of type 2 diabetes: a systematic review

Historical studies on the use of Rhubarb in Japan

Clopidogrel-induced drug-induced hypersensitivity syndrome following percutaneous coronary intervention: a case report of therapeutic dilemma and management strategy

Editorial: Digital health innovations in Africa: harnessing AI, telemedicine, and personalized medicine for improved healthcare

Licochalcone B suppresses oxidative stress and apoptosis accompanied by upregulating Nrf2/HO-1 pathway to ameliorate diabetic nephropathy in mice

Evaluating a multifaceted stewardship intervention on proton pump inhibitor utilization: an interrupted time-series analysis of prescribing patterns in a northwest Chinese hospital

Sphingosine-1-phosphate receptor signaling regulates an ERK1/2–p65 molecular switch in macrophages during Leishmania donovani infection