Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Published on 19 Mar 2025

Ethanol extract of Portulaca oleracea L. mitigates atherosclerosis through modulation of cholesterol efflux and uptake pathways

in Experimental Pharmacology and Drug Discovery

Bin Chen
Shanshan Sun
Jialei Fu
Ling Ge
Wei Nie
Peina Zhou
Peng Cao
Qian Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550812

1,635 views
1 citation

Editorial

Published on 19 Mar 2025

Editorial: Targeting cellular signalling pathways for disease therapy: the potential of cellular reprogramming and protein kinase inhibitors

in Experimental Pharmacology and Drug Discovery

Vanessa Marensi
Pedro Fontes Oliveira
Ariane Zamoner

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1580686

627 views

Editorial

Published on 19 Mar 2025

Editorial: Old drugs: confronting recent advancements and challenges

in Experimental Pharmacology and Drug Discovery

Anna Wiktorowska-Owczarek
Diego Iacono
Magdalena Jasińska-Stroschein

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565890

843 views

Editorial

Published on 18 Mar 2025

Editorial: Education and training in pharmaceutical medicine, medicines development and regulation for scientists worldwide

in Experimental Pharmacology and Drug Discovery

Bernd Rosenkranz
Tomoya Tachi
Rolf Bass

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1544678

618 views

Original Research

Published on 17 Mar 2025

FDA-approved drug repurposing screen identifies inhibitors of SARS-CoV-2 pseudovirus entry

in Experimental Pharmacology and Drug Discovery

Manisha Singh
Shruthi Shanmukha
Raghda E. Eldesouki
Maged M. Harraz

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1537912

1,362 views

Original Research

Published on 17 Mar 2025

Resveratrol prevents gallstones in mice fed on a high fat diet via regulating PPAR-γ and SR-BI

in Experimental Pharmacology and Drug Discovery

Menglu Zhao
Boya Xie
Yuxuan Li
Haiqing Dong
Sijia Jiang
Tiantian Zhu
Xiaolong Wu
Chengchen Xu
Jian Zhang
Shiyi Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1543865

1,578 views

Original Research

Published on 12 Mar 2025

Exosomes enriched with miR-124-3p show therapeutic potential in a new microfluidic triculture model that recapitulates neuron–glia crosstalk in Alzheimer’s disease

in Experimental Pharmacology and Drug Discovery

Artemizia Évora
Gonçalo Garcia
Ana Rubi
Eleonora De Vitis
Ana Teresa Matos
Ana Rita Vaz
Francesca Gervaso
Giuseppe Gigli
Alessandro Polini
Dora Brites

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1474012

2,810 views

Original Research

Published on 12 Mar 2025

The role of TRAF2 in pan-cancer revealed by integrating informatics and experimental validation

in Experimental Pharmacology and Drug Discovery

Xizheng Wang
Jianfeng Yuan
Chenchen Zhang
Lingyu Kong
Enzhen Wu
Jianxin Guo
Zhongbing Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1563435

1,579 views

Review

Published on 12 Mar 2025

Advances in the study of death receptor 5

in Experimental Pharmacology and Drug Discovery

Xuan Qiao
Shuang Guo
Zhiyun Meng
Hui Gan
Zhuona Wu
Yunbo Sun
Shuchen Liu
Guifang Dou
Ruolan Gu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1549808

865 views

Original Research

Published on 11 Mar 2025

Predicting protein–protein interactions in microbes associated with cardiovascular diseases using deep denoising autoencoders and evolutionary information

in Experimental Pharmacology and Drug Discovery

Senyu Zhou
Jian Luo
Mei Tang
Chaojun Li
Yang Li
Wenhua He

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1565860

603 views

Original Research

Published on 10 Mar 2025

Prediction of adverse drug reactions based on pharmacogenomics combination features: a preliminary study

in Experimental Pharmacology and Drug Discovery

Mingxiu He
Yiyang Shi
Fangfang Han
Yongming Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1448106

1,166 views

Original Research

Published on 10 Mar 2025

Antimicrobial photodynamic therapy with 5-aminolevulinic acid plus antibiotics: a promising treatment for tibial osteomyelitis caused by drug-resistant bacteria

in Experimental Pharmacology and Drug Discovery

Ju Zuo
Feiyan Kong
Xiyu Wang
Tianyu Wang
Jianxi Zhao
Zhanjuan Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1566744

776 views

Original Research

Published on 10 Mar 2025

Semaglutide promotes the proliferation and osteogenic differentiation of bone-derived mesenchymal stem cells through activation of the Wnt/LRP5/β-catenin signaling pathway

in Experimental Pharmacology and Drug Discovery

Yawei Tian
Huiming Liu
Xiaoxue Bao
Yukun Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1539411

2,230 views

Correction

Published on 07 Mar 2025

Corrigendum: Novel chemical scaffolds to inhibit the neutral amino acid transporter B0AT1 (SLC6A19), a potential target to treat metabolic diseases

in Experimental Pharmacology and Drug Discovery

Aditya Yadav
Nishank Shah
Praveen Kumar Tiwari
Kiran Javed
Qi Cheng
Indrapal Singh Aidhen
Stefan Bröer

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1485054

974 views

Editorial

Published on 07 Mar 2025

Editorial: Machine learning advancements in pharmacology: transforming drug discovery and healthcare

in Experimental Pharmacology and Drug Discovery

Moom Rahman Roosan
Ramgopal Mettu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1583486

986 views

Original Research

Published on 07 Mar 2025

Pharmacophore screening, molecular docking, and MD simulations for identification of VEGFR-2 and c-Met potential dual inhibitors

in Experimental Pharmacology and Drug Discovery

Junmin Dong
Xiaohua Hao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534707

1,457 views