Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Original Research

Accepted on 26 Sep 2025

20(S)-protopanaxadiol prolongs lifespan and enhances stress resistance in Caenorhabditis elegans via the insulin/IGF-1 signaling pathway

in Experimental Pharmacology and Drug Discovery

Zhuo Song
Xiuci Yan
Xiaohao Xu
Tingting Lou
Yu Wang
Limei Ren
Fangbing Liu
Shuai Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657436

Methods

Published on 26 Sep 2025

Enhancing therapeutic antibody profiling: orthogonal strategies for stability and quality assessment

in Experimental Pharmacology and Drug Discovery

Nicole G. Metzendorf
Inga Petersen
Greta Hultqvist

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1667210

419 views

Original Research

Published on 26 Sep 2025

Pharmacokinetics and safety of a fixed-dose combination of pregabalin and thioctic acid in healthy volunteers: a randomized, open-label, phase 1 crossover study

in Experimental Pharmacology and Drug Discovery

Edith Zárate
Cecilia Bravo-Lamicq
Diego Antonio Ocampo-Gutiérrez de Velasco
Oscar Arias-Carrión

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1692519

650 views

Original Research

Published on 26 Sep 2025

Neurotherapeutics across blood–brain barrier: screening of BBB-permeable and CNS-active molecules for neurodegenerative disease

in Experimental Pharmacology and Drug Discovery

D. Mohan Kumar
Priti Talwar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1616144

519 views

Mini Review

Accepted on 25 Sep 2025

The Computationally Guided Design of Selective Targeters of Multiple Proteins (STaMPs) as a New Opportunity for Small Molecule Drug Discovery

in Experimental Pharmacology and Drug Discovery

Thomas M Kaiser

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1691119

277 views

Original Research

Accepted on 25 Sep 2025

HuangLian-4 Alleviates Myocardial Ischemia-Reperfusion Injury by Activating the Pro-Survival STAT3 Signaling Pathway

in Experimental Pharmacology and Drug Discovery

Chelimuge Gong
Dalintai Wang
Qingshan Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683575

172 views

Original Research

Published on 25 Sep 2025

Biosynthesized zinc oxide nanoparticles from Cycas revoluta seed extract demonstrate significant wound healing, antimicrobial, antioxidant, and cytotoxic potential

in Experimental Pharmacology and Drug Discovery

Hajar Hassan AlWadai
Shifhali Morabad
Uday M. Muddapur
Abdulrahman Manaa Alamri
Bader Aldoah
Adel Moalwi
Nasser A. N. Alzerwi
Saeed Ali Alsareii
Mater H. Mahnashi
Ibrahim Ahmed Shaikh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1605717

677 views

Original Research

Accepted on 24 Sep 2025

Topical prevention from High Energy Visible light-induced pigmentation by 2-Mercaptonicotinoyl glycine, but not by Ascorbic Acid antioxidant: 2 randomized controlled trials

in Experimental Pharmacology and Drug Discovery

Virginie Piffaut
Romain De Dormael
Jean-Philippe Belaidi
Laudine Bertrand
Thierry Passeron
Françoise Bernerd
Claire Marionnet

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1651068

313 views

Systematic Review

Published on 24 Sep 2025

Exploring the potential of computer simulation models in drug testing and biomedical research: a systematic review

in Experimental Pharmacology and Drug Discovery

Rahul Mittal
Alan Ho
Harini Adivikolanu
Muskaan Sawhney
Joana R. N. Lemos
Mannat Mittal
Khemraj Hirani

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1644907

583 views

Original Research

Published on 24 Sep 2025

Insecticidal activity of the linear pseudoscorpion venom peptide Ammogarypin revealed by functional profiling

in Experimental Pharmacology and Drug Discovery

Maurice Pierry
Ludwig Dersch
Jonas Krämer
Lennart Schulte
Kornelia Hardes
Tobias Kessel
Jens Grotmann
Maximilian Seip
Andreas Vilcinskas
Tim Lüddecke

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1661173

636 views

Original Research

Published on 24 Sep 2025

Multi-pathway mechanisms of Liujunzi decoction in promoting glioma apoptosis and reversing drug resistance: network pharmacology and experimental validation

in Experimental Pharmacology and Drug Discovery

Jinxiang Huang
Shengnan Lin
Lei Lin
Luning Xu
Dezhi Kang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682550

465 views

Original Research

Published on 24 Sep 2025

Integrating network analysis and experimental validation to reveal the ferroptosis-associated mechanism of acteoside in the treatment of diabetic nephropathy

in Experimental Pharmacology and Drug Discovery

Zheng Luo
Shu-Jiao Zhang
Jing-Yi Tang
Yuanyuan Deng
Yi Kang
Xing-Hua Zhang
Hong-Mei Lu
Yao-Xian Wang
Wei-Jing Liu
Yu Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1660227

746 views

Editorial

Accepted on 23 Sep 2025

Editorial: Opportunities and Challenges in Drug Repurposing

in Experimental Pharmacology and Drug Discovery

Ihosvany Camps
Stephan R Künzel
Mario Schubert
Ramendra K. Singh

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1709217

764 views

Review

Accepted on 23 Sep 2025

Decoding the Structural and Functional Diversity of GABAA Receptors: From Ensemble Logic to Therapeutic Opportunities

in Experimental Pharmacology and Drug Discovery

Mario Treviño
Magdalena Guerra Crespo
Francisco J. Padilla-Godínez
Oskar Soto
Elias Manjarrez
Emmanuel Ortega-Robles
Julieta Rodríguez-de Ita
Oscar Arias-Carrión

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697905

238 views

Review

Accepted on 23 Sep 2025

Emerging Therapeutic Potential of Glucagon-Like Peptide-1 Receptor Agonists in Knee Osteoarthritis: A Systematic Review

in Experimental Pharmacology and Drug Discovery

Yapeng Li
Lanbo Yang
Feng Li
Jia Fu
Wangyu Zhao
Xiaolong Wu
Jiayi Guo
Chen Yue

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1627691

247 views

Review

Published on 23 Sep 2025

Betulinic acid and obesity-related disorders

in Experimental Pharmacology and Drug Discovery

Lara Azevedo
Ricardo Ferraz
Mónica Vieira
Cristina Prudêncio
Sílvia Fernandes

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1674713

866 views