Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Correction

Published on 05 Dec 2025

Correction: Transdermal administration of herbal essential oil alleviates high-fat diet-induced obesity by regulating metabolism and gut microbiota

in Experimental Pharmacology and Drug Discovery

Zu-Wen Ye
Qi-Yue Yang
Dong-Hua Yang
Qiao-Hong Lin
Xiao-Xia Liu
Feng-Qin Li
Fang-Fang Yan
Ping Luo
Si Qin
Fang Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1743063

Mini Review

Published on 04 Dec 2025

Effect of plant-derived exosome-like nanoparticles in ultraviolet-induced skin photoaging

in Experimental Pharmacology and Drug Discovery

Hai Dong
Yi Deng
Jiayan Li
Wen Lin
Yangyan Luo
Yuan Jiang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721879

192 views

Original Research

Published on 04 Dec 2025

A food-medicine homology formulation ameliorates atherosclerosis by attenuating dyslipidemia and inflammation via the PI3K/Akt/NF-κB pathway

in Experimental Pharmacology and Drug Discovery

Yadong Zheng
Kaili Chen
Shuo Zhang
Junsong Jing
Zhihao Zhou
Junfeng Lu
Christian Holscher
Wenlong Chen
Liguo Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1710585

890 views

Original Research

Accepted on 03 Dec 2025

Mechanistic Insights into Shenqi Dihuang Decoction in the Treatment of Immunoglobulin A Nephropathy

in Experimental Pharmacology and Drug Discovery

Yachan Gao
Xinxin Pang
Dongdong Li
Xiaoyong Chen
Dongyang Li
Zhenyi Chen

Frontiers in Pharmacology

Original Research

Accepted on 03 Dec 2025

Identify the Therapeutic Role and Potential Mechanism of α-Cyperone in diminished ovarian reserve Based on Network Pharmacology, Molecular docking, Lip-MS and Experimental Validation

in Experimental Pharmacology and Drug Discovery

Jingwen Guo
Xitang Yang
Xue Chen
Rong Hu
Hua Guo

Frontiers in Pharmacology

Original Research

Published on 03 Dec 2025

An integrated multimodal approach to drug repurposing in endometriosis, using ROR1 as a target

in Experimental Pharmacology and Drug Discovery

Kate Gunther
Dongli Liu
Gill Stannard
Melissa Holmes
Christine Loo
Belinda Guo
Nikola Bowden
Jason Abbott
Caroline E. Ford

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1716062

468 views

Review

Published on 03 Dec 2025

Preparation and biomedical application of light-responsive hydrogels based on natural products

in Experimental Pharmacology and Drug Discovery

Xinyi Fan
Haihua Shang
Liyuan Ji
Shitang Ma
Maoliang Liao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714907

206 views

Original Research

Published on 03 Dec 2025

Novel drug candidates targeting Toxoplasma gondii in maternal–fetal interface models

in Experimental Pharmacology and Drug Discovery

Rafael Martins de Oliveira
Natália Carine Lima dos Santos
Marcos Paulo Oliveira Almeida
Joed Pires De Lima Júnior
Guilherme De Souza
Matheus Carvalho Barbosa
Guilherme Vieira Faria
Marina Paschoalino
Rosiane Nascimento Alves
Angelica Oliveira Gomes

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1673462

414 views

Review

Published on 03 Dec 2025

Treatment strategies for motor fluctuations in Parkinson’s disease: a systematic review of efficacy, functionality, and drug accessibility with a focus on Latin America

in Experimental Pharmacology and Drug Discovery

Oscar Arias-Carrión
Emmanuel Ortega-Robles

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1725248

371 views

Original Research

Published on 02 Dec 2025

The protective effects and mechanisms of rosmarinic acid against Pseudomonas aeruginosa infection in Caenorhabditis elegans

in Experimental Pharmacology and Drug Discovery

Ying Zhang
Chengjie Shu
Zhuohang Li
Man Qu
Chunwu Wang
Shihui Nie
Qijiang Xu
Shunlin Gu
Mingjie Fan
Baojun Shi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1701885

296 views

Review

Published on 01 Dec 2025

Repurposing dimethyl fumarate for cancer therapy: current evidence and future directions

in Experimental Pharmacology and Drug Discovery

Mingjuan Zhang
Yaping Jing
Qingbin Cui

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1721876

274 views

Original Research

Published on 01 Dec 2025

Decoding the therapeutic potential mechanism of Cornus officinalis in Parkinson’s disease: a network pharmacology insight

in Experimental Pharmacology and Drug Discovery

Zheng Wu
Jiwei Zhao
Wen Wang
Yuan Dong
Taotao Zhou
Yide Feng
Yalan Deng
Yingmei Feng

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1714796

476 views

Original Research

Published on 01 Dec 2025

Improved exposure of curcumin-loaded nanocapsules: drug quantification in LPS-induced Drosophila melanogaster and pharmacokinetics in Wistar rats

in Experimental Pharmacology and Drug Discovery

Ana Pozzato Funghetto-Ribeiro
Camila de Oliveira Pacheco
Flávia Elizabete Guerra Teixeira
Joane Ferreira
Eliana Fernandes
Gustavo Guerra
Francine Johansson Azeredo
Sandra Elisa Haas

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1688992

269 views

Original Research

Published on 01 Dec 2025

Integrating multi-omics, network pharmacology, and experimental validation to unveil the molecular mechanisms of Fructus Xanthii in treating asthma

in Experimental Pharmacology and Drug Discovery

Yiqun Dong
Zhaosen Fan
Xiaoxiao Li
Yucheng Ming
Dong Wang
Yuanda Song
Youpeng Fan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1722150

397 views

Review

Accepted on 29 Nov 2025

Systemic Metabolic Reprogramming and Microbial Dysbiosis in Fabry Disease: Multi-Omics Mechanisms and Implications for Drug Development

in Experimental Pharmacology and Drug Discovery

Nuria Gómez-Cebrián
María Chovi Trull
Elena Gras Colomer
María Dolores Edo Solsona
José Luis Poveda Andrés
Leonor Puchades-Carrasco

Frontiers in Pharmacology

356 views

Original Research

Accepted on 29 Nov 2025

Efficacy and safety of vunakizumab in moderate-to-severe plaque psoriasis patients with different body mass index: A post hoc analysis based on a phase III trial

in Experimental Pharmacology and Drug Discovery

Xin Wang
Linfeng Li

Frontiers in Pharmacology