Frontiers in Pharmacology | Experimental Pharmacology and Drug Discovery

Systematic Review

Accepted on 22 May 2025

Mesenchymal stem cell-derived exosomes for the treatment of knee osteoarthritis: a systematic review and meta-analysis based on rat model

in Experimental Pharmacology and Drug Discovery

Zhe Wang
Zihao Hu
Lin Niu
Yongsheng Xu
Yansong Qi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1588841

214 views

Original Research

Published on 22 May 2025

Repurposing of the small-molecule adrenoreceptor-inhibitor carvedilol for treatment of the fibrotic lung

in Experimental Pharmacology and Drug Discovery

Maria Jordan
Kevin Schmidt
Maximilian Fuchs
Annette Just
Angelika Pfanne
Lena Willmer
Lavinia Neubert
Christopher Werlein
Patrick Zardo
Andreas Pich

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1534989

621 views

Original Research

Published on 22 May 2025

Exploring the molecular mechanisms of huperzine a in the treatment of rosacea through network pharmacology, machine learning, and molecular dynamics simulations

in Experimental Pharmacology and Drug Discovery

Xin Luo
Suhan Yang
Lian Zhong
Peng Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586829

380 views

Review

Published on 22 May 2025

From malaria fighter to diabetes guardian: the emerging role of artesunate in treating diabetes and diabetic complications

in Experimental Pharmacology and Drug Discovery

Dongze Li
Qingyue Liang
Linghao Xu
Li Zhang
Qiming Gong
Tingting Zhou
Changfang Luo
Wei Huang
Yuan Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1583575

345 views

Systematic Review

Published on 21 May 2025

Comparative efficacy of teriparatide and bisphosphonates or denosumab vs. teriparatide monotherapy in osteoporosis: a meta-analysis

in Experimental Pharmacology and Drug Discovery

Huan Jin
Cai Huang
Yan Zhang
Ying Dong
Qi Xiong
Di Wang
Ziyi He
Lin Shen
Chen Ma
Zixian Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1605279

316 views

Original Research

Published on 21 May 2025

Metabolomics combined with molecular docking and dynamics simulation to investigate the mechanism of action of Fibraurea recisa Pierre in the treatment of chronic urticaria

in Experimental Pharmacology and Drug Discovery

Tian Xiao
Jie Tao
Jiaoyang Tan
Zhourong Zhao
Liping Yang
Chao Zhang
Xiaohua Duan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1571819

322 views

Original Research

Published on 21 May 2025

Effectiveness and priority of irradiation and six NSAIDs in prevention heterotopic ossification after total hip arthroplasty: a network meta-analysis of randomized controlled studies

in Experimental Pharmacology and Drug Discovery

Fei Yang
Lei Wen
Changshun Chen
Qiao Zhao
Zhiwei Feng
Bin Ran
Xuwei Luo
Dongqin Xiao
Qifan Fang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1601349

323 views

Original Research

Published on 20 May 2025

LncRNA OIP5-AS1 suppresses lung adenocarcinoma progression and modulates macrophage polarization through the miR-429/DOCK4 regulatory axis

in Experimental Pharmacology and Drug Discovery

Yihan Liu
Yuhua Wang
Long Cui
Runze Li
Dan Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1569644

478 views

Original Research

Published on 20 May 2025

Exploring the antidiabetic potential of Octhochloa compressa: a comprehensive study on chemical profiling, in vitro, in vivo and in silico pharmacological properties

in Experimental Pharmacology and Drug Discovery

Jawaria Aslam
Mirza Imran Shahzad
Hanan Y. Aati
Kashif-ur-Rehman Khan
Maria Aslam
Athar Jamal
Umar Farooq
Bilal Ahmad Ghalloo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1541482

351 views

Systematic Review

Published on 20 May 2025

From basic to clinical translation: advances and perspectives of photodynamic nanodrugs

in Experimental Pharmacology and Drug Discovery

Shitang Ma
Shasha Shi
Xin Hu
Ye Zhao
Boran Yang
Maoliang Liao
Baowei Lu
Qilin Xu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1606372

322 views

Original Research

Accepted on 19 May 2025

Reversal of ABCG2-mediated drug resistance by Tinodasertib (ETC-206)

in Experimental Pharmacology and Drug Discovery

HAIGAN YANG
Zheshen Li
Zhuo-Xun Wu
Xiang Chen
Letao Bo
Harsh Patel
Bohan Zhang
Wenjun Xiong
Wei Wang
Zhe-Sheng Chen

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1606857

Editorial

Published on 19 May 2025

Editorial: Exploring new therapeutic frontiers in Glaucoma: from molecular targets to patient outcomes

in Experimental Pharmacology and Drug Discovery

Silvia Sgambellone
Arianna Carolina Rosa
Ana Raquel Santiago
Ivana Josimovic
Laura Lucarini

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1624534

358 views

Original Research

Published on 19 May 2025

Gambogic acid targets HSP90 to alleviate DSS-induced colitis via inhibiting the necroptosis of intestinal epithelial cells

in Experimental Pharmacology and Drug Discovery

Yuanyuan Wang
Siqi Liu
Keyi Lu
Erping Xu
Zhibin Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1586705

344 views

Original Research

Accepted on 16 May 2025

Integrating Network Pharmacology, IPA, and Molecular Docking to Reveal the Anti-Osteoporosis Effects of EA and EB via the FAK Pathway Abstract：

in Experimental Pharmacology and Drug Discovery

Ziheng Wei
Fei You
Henghui Li
Si Wu
Fen Tang
Xiangyang Wan
Huizhong Dong
Wenxuan Huang
Songyan Gao
Bo Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1532665

261 views

Systematic Review

Accepted on 16 May 2025

Analysis of research trends and development prospects of soluble guanylate cyclase stimulators/activators: using bibliometric methods

in Experimental Pharmacology and Drug Discovery

Jing Zhang
Bingju Yan
Jun Wang
Hongxia Yuan

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1501330

168 views

Original Research

Accepted on 16 May 2025

Molecular pharmacokinetic mechanism of quercetin-encapsulated polymeric micelles in alleviating cisplatin-induced nephrotoxicity and enhancing antineoplastic effects

in Experimental Pharmacology and Drug Discovery

Tangna Hao
Xiaokui Huo
Zhen Li
Changyuan Wang
Sha Wu
Anni Song
Fengyu Zhang
Kexin Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1590688

171 views