Frontiers in Pharmacology | Integrative and Regenerative Pharmacology

Original Research

Published on 17 Feb 2026

Pharmacological activation of SIRT1–AMPK by ginsenoside Rb1: a novel therapeutic strategy for pressure injury via dual suppression of ferroptosis and inflammation

in Integrative and Regenerative Pharmacology

Hongbo Zhu
Hang Li
Yinong Shi
Hua Zhi
Xuelu Zhao
Zhiwen Wang
Jinhui Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1683479

325 views

Review

Published on 12 Feb 2026

Use of genetics in the prediction of success in male pattern hair loss therapy and mechanistic studies

in Integrative and Regenerative Pharmacology

Gustavo Torres de Souza
Greg Williams
Carolina Costa Vicente Silva
Caroline Brandão Chiovatto
Gorana Kuka Epstein
Laura Vila-Vecilla
Valentina Russo

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1765808

703 views

Original Research

Accepted on 06 Feb 2026

Asiaticoside promotes intestinal epithelial proliferation and barrier function in ischemia/reperfusion injury by activating FoxM1

in Integrative and Regenerative Pharmacology

Guo Zu
Chenglin Zhao
Qingyu Du
Yuhang Wu
Xiangwen Zhang

Frontiers in Pharmacology

141 views

Review

Published on 05 Feb 2026

Mesenchymal stem cell-derived exosomes in myocardial infarction repair: therapeutic potential and scaffold-based delivery strategies

in Integrative and Regenerative Pharmacology

Vajiheh Azimian Zavareh
Negar Eslampoor
Sanaz Panahi-Alanagh
Latifeh Malekmohammad
Agata Stanek

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1762630

957 views

Review

Accepted on 02 Feb 2026

Regulatory Mechanisms of Deer Antler Extracellular Vesicles in Multilevel Tissue Repair: A state-of-the-art Review

in Integrative and Regenerative Pharmacology

Lei Yuan
Bowen Deng
Fengrui Zhang
Deyou Wang
Haiyan Chen

Frontiers in Pharmacology

119 views

Review

Published on 21 Jan 2026

Expanding the therapeutic landscape of minoxidil for androgenetic alopecia: topical, oral and sublingual formulations

in Integrative and Regenerative Pharmacology

Flavia Rodrigues Dias
Shin Shen Yong
Holly FitzGerald
Rodney D. Sinclair
Bevin Bhoyrul

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1718208

2,069 views

Editorial

Published on 21 Jan 2026

Editorial: Advancements in therapeutic strategies for skeletal muscle and cardiovascular diseases: integrating innovative approaches for enhanced outcomes

in Integrative and Regenerative Pharmacology

Sara Carolina Vieira Terra
Leonardo Martin
Roberta Sessa Stilhano

Frontiers in Pharmacology

doi 10.3389/fphar.2026.1779437

555 views

Editorial

Published on 08 Jan 2026

Editorial: Mesenchymal stem cells and derived extracellular vesicles as next-generation biological drugs for tissue regeneration

in Integrative and Regenerative Pharmacology

Silvia Barbon
Antara Banerjee
Andrea Porzionato

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1770314

664 views

Review

Published on 05 Jan 2026

Osteoarthritis: multitissue pathology, molecular mechanisms, clinical management, and emerging precision and regenerative therapies

in Integrative and Regenerative Pharmacology

Lina Qiu
Ahmad Alhaskawi
Safwat Adel Abdo Moqbel

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1697192

1,456 views
1 citation

Original Research

Published on 05 Jan 2026

Randomized trial and multi-omics, machine learning–based mechanistic exploration of daixie decoction granules in type 2 diabetes

in Integrative and Regenerative Pharmacology

Zhong Zheng
Kepei Zhang
Xiaogang Ma
Yuezhou Qian
Miao Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1723584

1,026 views

Original Research

Published on 19 Dec 2025

Generation of Phd2-haplodeficient macrophages with proresolution effects for the treatment of limb ischemia

in Integrative and Regenerative Pharmacology

Patrícia Terra Alves
Sayone Andrade de Moura
Helen Taylor
Antonella Fidanza
Cristiane Damas Gil
Leonardo Martin
Aléx Martins Nasare
André van Helvoort Lengert
Bianca Bonetto Moreno Garcia
Gabriel Cicolin Guarache

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1698623

1,610 views

Original Research

Published on 12 Dec 2025

Alginate-encapsulated muscle-derived stem cell spheroids promote muscle regeneration in a murine model of volumetric muscle loss

in Integrative and Regenerative Pharmacology

Lucas Pari Mitre
Giovana Zanetti Ivanov
Shahin Shams
Fabio Yamaguchi
André Petraconi
Ricardo Jorge Espanhol Andrade
Eduardo Silva
Leonardo Martin
Roberta Sessa Stilhano

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1657563

1,324 views

Editorial

Published on 09 Dec 2025

Editorial: Innovative approaches for wound treatment

in Integrative and Regenerative Pharmacology

Junxiao Zhang
Shenglin Geng
Guojuan Fan
Jinlong Ma

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1738213

755 views

Review

Published on 04 Dec 2025

The PI3K/AKT/mTOR pathway in scar remodeling and keloid formation: mechanisms and therapeutic perspectives

in Integrative and Regenerative Pharmacology

Jing Liu
Junfei Yan
Shengbin Qi
Jie Zhang
Xin Zhang
Yaping Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1678953

2,301 views

Original Research

Published on 27 Nov 2025

Ofatumumab-mediated CD20+ B-cell depletion promotes neuromuscular junction functional recovery and sustains long-term efficacy in refractory generalized myasthenia gravis

in Integrative and Regenerative Pharmacology

Zhuangzhuang Ren
Yuping Chen
Yudan Liu
Yan Wang
Shengjie Xu
Yanhua Yang
Feng Qiu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1728721

1,592 views

Original Research

Published on 27 Nov 2025

Gentamicin-loaded exosomes from IMMUNEPOTENT CRP enhance healing of infected diabetic wound in mice

in Integrative and Regenerative Pharmacology

Paola Leonor García Coronado
Brandon Alberto Garza Martínez
Kenia Arisbe Moreno Amador
David Reding Hernández
Diana G. Zárate Triviño
Diana Elia Caballero Hernández
Pablo Zapata Benavides
Gabriel Luna Barcenas
Cristina Rodríguez‐Padilla
Moisés Armides Franco Molina

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1682468

1,316 views

Original Research

Published on 27 Nov 2025

Xiaozhi Yufa decoction ameliorates androgenetic alopecia through inhibition of MAPK signaling and regulation of lipid metabolism

in Integrative and Regenerative Pharmacology

Yiyu Guo
Jie Wu
Yu Lu
Jianping Qin
Lanlan Huang
Fengrui Zhang
Xiaomei Zhou
Dengke Yang
Jianzhou Ye

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1724224

1,409 views

Review

Published on 26 Nov 2025

Endoplasmic reticulum stress and exosomes secretion in the pathogenesis of inflammatory bowel disease: a concise summary of research findings

in Integrative and Regenerative Pharmacology

Ashiq Shibili P
Antara Banerjee
Soham Chakraborty
Suresh Babu Kondaveeti
Andrea Porzionato
Silvia Barbon
Surajit Pathak

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1702825

2,001 views

Review

Published on 26 Nov 2025

Eryptosis in renal anemia: mechanisms, clinical implications, and therapeutic targeting

in Integrative and Regenerative Pharmacology

Xiang Deng
Xiangyu Gong
Yi Huang
Jie Zhou
Sichong Ren

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1718803

1,595 views
3 citations

Specialty Grand Challenge

Published on 20 Nov 2025

Unifying pharmacology, systems biology, and regenerative medicine to advance personalized therapies

in Integrative and Regenerative Pharmacology

Albino Martins

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1729610

1,387 views

Original Research

Published on 12 Nov 2025

Early intervention with extracellular vesicles derived from human umbilical cord mesenchymal stem cells enhances survival and functional recovery after spinal cord injury in rats

in Integrative and Regenerative Pharmacology

Barbara Porto Cipriano
Rachel Santana Cunha
Thaís Alves de Santana
Kátia Nunes da Silva
Erick Correia Loiola
Júlio César Queiroz Figueiredo
Elisama Araújo da Silva
Adne Vitória Rocha de Lima
Erik Aranha Rossi
Igor Campos da Silva

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1695914

1,820 views

Original Research

Published on 15 Oct 2025

Combined multi-omics approach to identify the key metabolites, key microorganisms and biomarkers correlated with the neutrophil extracellular traps-associated gene TIMP1 in osteoarthritis

in Integrative and Regenerative Pharmacology

Yaoyu Xiang
Jizheng Li
Xidan Hu
Xianguang Yang
Fei Sun
Jing Yang
Weiqing Ge
Tao Zhou
En Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1665228

2,864 views
1 citation

Original Research

Published on 15 Oct 2025

Simvastatin impairs fracture healing under ischemic conditions

in Integrative and Regenerative Pharmacology

S. Schreiber
J. Stutz
J. Finkler
W. Metzger
T. Fritz
D. Osche
H. Hawi
S. Razaeian
M. Örgel
M. D. Menger

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693683

1,241 views

Review

Published on 07 Oct 2025

3D in vitro blood–brain barrier models: recent advances and their role in brain disease research and therapy

in Integrative and Regenerative Pharmacology

Laura O’Halloran
Olutoyosi Akinsete
A. Leah Kogan
Michelle Wrona
Amira F. Mahdi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1637602

8,845 views
2 citations

291 articles

articles

Pharmacological activation of SIRT1–AMPK by ginsenoside Rb1: a novel therapeutic strategy for pressure injury via dual suppression of ferroptosis and inflammation

Use of genetics in the prediction of success in male pattern hair loss therapy and mechanistic studies

Asiaticoside promotes intestinal epithelial proliferation and barrier function in ischemia/reperfusion injury by activating FoxM1

Mesenchymal stem cell-derived exosomes in myocardial infarction repair: therapeutic potential and scaffold-based delivery strategies

Regulatory Mechanisms of Deer Antler Extracellular Vesicles in Multilevel Tissue Repair: A state-of-the-art Review

Expanding the therapeutic landscape of minoxidil for androgenetic alopecia: topical, oral and sublingual formulations

Editorial: Advancements in therapeutic strategies for skeletal muscle and cardiovascular diseases: integrating innovative approaches for enhanced outcomes

Editorial: Mesenchymal stem cells and derived extracellular vesicles as next-generation biological drugs for tissue regeneration

Osteoarthritis: multitissue pathology, molecular mechanisms, clinical management, and emerging precision and regenerative therapies

Randomized trial and multi-omics, machine learning–based mechanistic exploration of daixie decoction granules in type 2 diabetes

Generation of Phd2-haplodeficient macrophages with proresolution effects for the treatment of limb ischemia

Alginate-encapsulated muscle-derived stem cell spheroids promote muscle regeneration in a murine model of volumetric muscle loss

Editorial: Innovative approaches for wound treatment

The PI3K/AKT/mTOR pathway in scar remodeling and keloid formation: mechanisms and therapeutic perspectives

Ofatumumab-mediated CD20+ B-cell depletion promotes neuromuscular junction functional recovery and sustains long-term efficacy in refractory generalized myasthenia gravis

Gentamicin-loaded exosomes from IMMUNEPOTENT CRP enhance healing of infected diabetic wound in mice

Xiaozhi Yufa decoction ameliorates androgenetic alopecia through inhibition of MAPK signaling and regulation of lipid metabolism

Endoplasmic reticulum stress and exosomes secretion in the pathogenesis of inflammatory bowel disease: a concise summary of research findings

Eryptosis in renal anemia: mechanisms, clinical implications, and therapeutic targeting

Unifying pharmacology, systems biology, and regenerative medicine to advance personalized therapies

Early intervention with extracellular vesicles derived from human umbilical cord mesenchymal stem cells enhances survival and functional recovery after spinal cord injury in rats

Combined multi-omics approach to identify the key metabolites, key microorganisms and biomarkers correlated with the neutrophil extracellular traps-associated gene TIMP1 in osteoarthritis

Simvastatin impairs fracture healing under ischemic conditions

3D in vitro blood–brain barrier models: recent advances and their role in brain disease research and therapy