Frontiers in Pharmacology | Integrative and Regenerative Pharmacology

Specialty Grand Challenge

Accepted on 28 Oct 2025

Unifying pharmacology, systems biology, and regenerative medicine to advance personalized therapies

in Integrative and Regenerative Pharmacology

Albino Martins

Frontiers in Pharmacology

368 views

Original Research

Accepted on 22 Oct 2025

Early Intervention with Extracellular Vesicles Derived from Human Umbilical Cord Mesenchymal Stem Cells Enhances Survival and Functional Recovery after Spinal Cord Injury in Rats

in Integrative and Regenerative Pharmacology

Barbara Porto Cipriano
Rachel Santana Cunha
Thaís Alves de Santana
Kátia Nunes da Silva
Erick Correia Loiola
Júlio César Queiroz Figueiredo
Elisama Araújo da Silva
Erik Aranha Rossi
Adne Vitória Rocha de Lima
Igor Campos Da Silva

Frontiers in Pharmacology

Review

Accepted on 15 Oct 2025

The PI3K/AKT/mTOR Pathway in Scar Remodeling and Keloid Formation: Mechanisms and Therapeutic Perspectives

in Integrative and Regenerative Pharmacology

Jing Liu
Junfei Yan
Shengbin Qi
Jie Zhang
Xin Zhang
Yaping Zhao

Frontiers in Pharmacology

273 views

Original Research

Published on 15 Oct 2025

Combined multi-omics approach to identify the key metabolites, key microorganisms and biomarkers correlated with the neutrophil extracellular traps-associated gene TIMP1 in osteoarthritis

in Integrative and Regenerative Pharmacology

Yaoyu Xiang
Jizheng Li
Xidan Hu
Xianguang Yang
Fei Sun
Jing Yang
Weiqing Ge
Tao Zhou
En Song

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1665228

1,487 views

Original Research

Published on 15 Oct 2025

Simvastatin impairs fracture healing under ischemic conditions

in Integrative and Regenerative Pharmacology

S. Schreiber
J. Stutz
J. Finkler
W. Metzger
T. Fritz
D. Osche
H. Hawi
S. Razaeian
M. Örgel
M. D. Menger

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1693683

618 views

Review

Published on 07 Oct 2025

3D in vitro blood–brain barrier models: recent advances and their role in brain disease research and therapy

in Integrative and Regenerative Pharmacology

Laura O’Halloran
Olutoyosi Akinsete
A. Leah Kogan
Michelle Wrona
Amira F. Mahdi

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1637602

3,445 views

Review

Published on 25 Sep 2025

Adipose-derived stem cell exosomes: emerging roles and therapeutic application

in Integrative and Regenerative Pharmacology

Yuhan Gong
Hui Ma
Zhongren Zheng
Xinjie Wang
Jiahua Zhang
Xiaowei Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1637342

3,256 views

Mini Review

Published on 22 Sep 2025

Serotonin-modulating therapies for the management of chronic wounds

in Integrative and Regenerative Pharmacology

Anuj Budhiraja
Alisha Mehta
Johanna Ghebrehiwet-Kuflom
Janmesh D. Patel
Christiane How-Volkman
Lara Ali
Sara Dahle
Roslyn Rivkah Isseroff

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1656302

3,153 views

Correction

Published on 17 Sep 2025

Correction: Resveratrol and Angiogenin-2 combined with PEGDA/TCS hydrogel for the targeted therapy of hypoxic bone defects via activation of the autophagy pathway

in Integrative and Regenerative Pharmacology

Dehui Fan
Hengping Liu
Zhenning Zhang
Meiyi Su
Zhixian Yuan
Ying Lin
Shuquan Yang
Wenqiang Li
Xintao Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1597755

1,443 views

Original Research

Published on 15 Sep 2025

Modulation of ASC-derived extracellular vesicles containing cargo that specifically enhances wound healing

in Integrative and Regenerative Pharmacology

Jodi P. Gurney
John W. Ludlow
Michael J. Van Kanegan
Robin L. Smith

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1635151

1,536 views

Review

Published on 12 Sep 2025

Mesenchymal stromal cell-laden hydrogels in tissue regeneration: insights from preclinical and clinical research

in Integrative and Regenerative Pharmacology

Silvia Barbon
Senthilkumar Rajendran
Antara Banerjee
Pier Paolo Parnigotto
Raffaele De Caro
Veronica Macchi
Andrea Porzionato

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1670649

2,979 views

Review

Published on 03 Sep 2025

Efficacy of platelet-rich plasma injection with percutaneous endoscopic lumbar discectomy for lumbar disc herniation: a systematic review and meta-analysis

in Integrative and Regenerative Pharmacology

Yu Zhang
Jidong Ju
Jinchun Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1622974

3,838 views

Original Research

Published on 28 Aug 2025

A comprehensive bibliometric exploration of hydrogel applications in spinal cord injury

in Integrative and Regenerative Pharmacology

Guosong Han
Huihui Zhang
Zhixiang Li

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1606186

2,225 views

Original Research

Published on 21 Aug 2025

2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity

in Integrative and Regenerative Pharmacology

Yeasmin Akter Munni
Khoa Nguyen Tran
Seon-Min Jeon
Meeyul Hwang
Jong-Won Yoon
Young-Ha Song
Tae Woo Oh
Sang Il Gum
In-Jun Yang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1598030

2,550 views

Original Research

Published on 30 Jun 2025

Narirutin treatment accelerates the process of diabetic wound repair by regulating phenotype switching of macrophages through affecting metabolic reprogramming

in Integrative and Regenerative Pharmacology

Liang Liu
Han Wang
Juan Zhou
Jing Lu
Yan Zhang
Haiyan Liu
Li Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1614967

2,453 views
1 citation

Review

Published on 24 Jun 2025

Advances in hydrogel-based materials for breast cancer bone metastasis: from targeted drug delivery to bone microenvironment remodeling

in Integrative and Regenerative Pharmacology

Jiayi Chen
Jun Ma
Zhuoming Xu
Huanhuan Luo
Chenhong Qian

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1627883

2,281 views
1 citation