Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 12 May 2025

Exploring the mechanisms and targets of proton pump inhibitors-induced osteoporosis through network toxicology, molecular docking, and molecular dynamics simulations

in Predictive Toxicology

Yaqi Mu
Yaqi Zhou
Xinan Zhang
Yiming Shao

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1592048

5,816 views
5 citations

Editorial

Published on 17 Apr 2025

Editorial: Model organisms in predictive toxicology 2023

in Predictive Toxicology

Cristina Luceri
Abdulahad Dogan
Angel León-Buitimea

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1609126

1,270 views

Original Research

Published on 15 Apr 2025

Acute and subacute toxicity evaluation of ZhenzhuXiaoji decoction in preclinical models: implications for safe clinical use

in Predictive Toxicology

Songzhe Li
Shuchang Bao
Lingyun Cai
Baolong Li
Yue Sun
Yang Sun

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1554732

2,166 views

Original Research

Published on 08 Apr 2025

Risk of medication-induced lactic acidosis and hyperlactatemia: a pharmacovigilance study of the United States Food and Drug Administration’s Adverse Event Reporting System database

in Predictive Toxicology

Houci Yang
Haibin Dai
Xveying Chen
Jiaqi Huang
Fangzhou Miao
Jiani Lv
Jiali Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1555955

4,899 views
4 citations

Case Report

Published on 05 Mar 2025

Transdermal fentanyl induced paralytic intestinal obstruction in advanced liver cancer: a case report

in Predictive Toxicology

Chen Li
Jindong Chu
Xiaodong Jia
Haibin Su

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1550296

2,908 views
4 citations

Original Research

Published on 28 Feb 2025

Blood compatibility evaluation of polydopamine nanoparticles

in Predictive Toxicology

Sha Li
Si-Ming Yan
Li-Wei Zhang
Xiao-Yan Yang
Zhong Guo

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1530650

2,185 views
3 citations

Editorial

Published on 25 Feb 2025

Editorial: Methods in predictive toxicology 2023

in Predictive Toxicology

Sankalp Jain
Serena Manganelli
Vitalina Gryshkova
Maria Armanda Rodrigues
Aniket Magarkar

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1556352

1,817 views

Original Research

Published on 13 Feb 2025

Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways

in Predictive Toxicology

Qingshan Tang
Jiachen Dong
Feng Zhang
Dan Zhao
Qi Yang
Jiayu Wen
Yuhao Sun
Jifu Wei
Zhixian Liu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1489210

3,399 views
3 citations

Original Research

Published on 06 Feb 2025

Safety assessment of rosuvastatin-fenofibrate combination in the treatment of hyperlipidemia based on FDA’s adverse event reporting system database

in Predictive Toxicology

Qun Li
Wenya Shan
Saiwei Wu

Frontiers in Pharmacology

doi 10.3389/fphar.2025.1415701

6,281 views
2 citations

Original Research

Published on 24 Jan 2025

MDTR: a knowledge-guided interpretable representation for quantifying liver toxicity at transcriptomic level

in Predictive Toxicology

Inyoung Sung
Sangseon Lee
Dongmin Bang
Jungseob Yi
Sunho Lee
Sun Kim

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1398370

2,458 views
1 citation

Case Report

Published on 09 Jan 2025

Case report: Accidental aconitine poisoning caused by the inappropriate use of a type of Chinese patent medicine

in Predictive Toxicology

Ruikai Shang
Hongyu Liu
Qiaoxin Tian
Yuru Liu
Xiangdong Jian
Qilu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1426006

3,075 views
3 citations

Review

Published on 09 Jan 2025

Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies

in Predictive Toxicology

Zhichao Liu
Yongkang Gan
Zhen Shen
Siqi Cai
Xizhen Wang
Yong Li
Xiaofeng Li
Huanjie Fu
Jinhong Chen
Ningcen Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1527901

3,789 views
4 citations

Case Report

Published on 07 Jan 2025

Ceftriaxone-induced hemolytic anemia managed successfully in a 54-year-old woman: a case report and literature review

in Predictive Toxicology

Liqian Zhang
Wenfeng Huang
Jiakai Xu
Yunxing Li
Jihong Zhu

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1505366

2,325 views
2 citations

Original Research

Published on 06 Jan 2025

CPT1 deficiency blocks autophagic flux to promote lipid accumulation induced by co-exposure to polystyrene microplastic and cadmium

in Predictive Toxicology

Zhixuan Chen
Huayi Qu
Jian Sun
Tao Wang
Yan Yuan
Jianhong Gu
Jianchun Bian
Zongping Liu
Hui Zou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1533188

2,362 views
1 citation

Original Research

Published on 17 Dec 2024

Quantitative study on hepatic genotoxicity of neodymium and its molecular mechanisms based on Benchmark Dose method

in Predictive Toxicology

Ning Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1484111

1,918 views
4 citations

Original Research

Published on 28 Nov 2024

Integration of genomics, clinical characteristics and baseline biological profiles to predict the risk of liver injury induced by high-dose methotrexate

in Predictive Toxicology

Chenquan Lin
Rui Ma
Xiao Zeng
Bikui Zhang
Ting Cao
Shimeng Jiao
Hui Chen
Yifang He
Mouze Liu
Hualin Cai

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1423214

2,488 views
2 citations

Case Report

Published on 26 Nov 2024

Case Report: Sudden death caused by methylene chloride poisoning

in Predictive Toxicology

Ruikai Shang
Qiaoxin Tian
Yuru Liu
Hongyu Liu
Xiangxing Zhang
Mengdi Shi
Xiangdong Jian
Qilu Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1471744

2,488 views
1 citation

Perspective

Published on 26 Nov 2024

Mitigating Paxlovid™-induced drug‒drug interaction toxicity: an in silico insight

in Predictive Toxicology

Giang H. Ta
Max K. Leong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1496630

1,399 views

Original Research

Published on 11 Nov 2024

Delayed immune-related adverse events profile associated with immune checkpoint inhibitors: a real-world analysis

in Predictive Toxicology

Yana Yang
Linman Li
Jing Tian
Linwen Ma
Yaoxin Wu
Qian Luo
Yan Luo

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1453429

4,116 views
9 citations

Original Research

Published on 05 Nov 2024

DDIT4/mTOR signaling pathway mediates cantharidin-induced hepatotoxicity and cellular damage

in Predictive Toxicology

Wenchao Tang
Yue Pan
Can Zhu
Didong Lou
Fang Peng
Qin Shi
Yuanyuan Xiao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1480512

3,379 views

Original Research

Published on 29 Oct 2024

Osteonecrosis of the jaw in patients with clear cell renal cell carcinoma treated with targeted agents: a case series and large-scale pharmacovigilance analysis

in Predictive Toxicology

Shuyun Wang
Rui Zhang
Song Wang
Qian Guo
Donghong Yin
Yan Song
Xianhua She
Xuyan Wang
Jinju Duan

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1309148

3,618 views
1 citation

Original Research

Published on 29 Oct 2024

Modelling hemodynamics regulation in rats and dogs to facilitate drugs safety risk assessment

in Predictive Toxicology

Christopher J. Morris
Michael G. Rolf
Linda Starnes
Inmaculada C. Villar
Amy Pointon
Holly Kimko
Giovanni Y. Di Veroli

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1402462

2,424 views
2 citations

Original Research

Published on 23 Oct 2024

Identification of human pregnane X receptor antagonists utilizing a high-throughput screening platform

in Predictive Toxicology

Caitlin Lynch
Ryan Margolis
Jacob Niebler
Jameson Travers
Srilatha Sakamuru
Tongan Zhao
Carleen Klumpp-Thomas
Ruili Huang
Menghang Xia

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1448744

3,312 views
1 citation

Original Research

Published on 18 Oct 2024

Monocrotaline-mediated autophagy via inhibiting PI3K/AKT/mTOR pathway induces apoptosis in rat hepatocytes

in Predictive Toxicology

Yazhou Guo
Yang Yuan
Ruibo Wang
Jun Bai
Yanqing Jia
Xinxin Qiu
Huafeng Niu
Long Li
Yan Luo
Baoyu Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1499116

2,291 views
2 citations