Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 10 Apr 2024

Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy

in Predictive Toxicology

James A. Coleman
Ruben Doste
Matteo Beltrami
Alessia Argirò
Raffaele Coppini
Iacopo Olivotto
Betty Raman
Alfonso Bueno-Orovio

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1379236

3,590 views
10 citations

Original Research

Published on 10 Apr 2024

Exploiting the predictive power of educated spheroids to detect immune-mediated idiosyncratic drug-induced liver injury: the case of troglitazone

in Predictive Toxicology

Salomé Roux
Sara Cherradi
Hong Tuan Duong

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1378371

3,893 views
6 citations

Case Report

Published on 27 Mar 2024

Case report: Paralytic ileus resulted from nirmatrelvir/ritonavir-tacrolimus drug-drug interaction in a systemic lupus erythematosus patient with COVID-19

in Predictive Toxicology

Wei Zhang
Xingguo Zhang
Jinming Han
Wen Zhang
Jiarui Xu
Xin Zhang
Hongjun Bian
Chong Meng
Deya Shang
Yi Zhou

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1389187

3,063 views
1 citation

Original Research

Published on 19 Mar 2024

Safety assessment of Acori Tatarinowii Rhizoma: acute and subacute oral toxicity

in Predictive Toxicology

Jia Liu
Xin Ping
Shu-jie Sun
Jiali Yang
Ye Lu
Lin Pei

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1377876

3,768 views
6 citations

Review

Published on 19 Mar 2024

Emerging insights into the impacts of heavy metals exposure on health, reproductive and productive performance of livestock

in Predictive Toxicology

Ali Afzal
Naima Mahreen

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1375137

20,538 views
69 citations

Original Research

Published on 18 Mar 2024

Product labeling accuracy and contamination analysis of commercially available cannabidiol product samples

in Predictive Toxicology

Barry E. Gidal
Ryan Vandrey
Chela Wallin
Sean Callan
Alan Sutton
Timothy B. Saurer
Jennifer L. Triemstra

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1335441

9,751 views
30 citations

Original Research

Published on 14 Mar 2024

Post-marketing safety evaluation of lurbinectedin: a pharmacovigilance analysis based on the FAERS database

in Predictive Toxicology

Zhao Li
Changying Guo
Xingfei Liu
Zhengzhou Qiu
Ruilin Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1368763

5,223 views
7 citations

Case Report

Published on 07 Mar 2024

Case Report: Minocycline-induced drug reaction with eosinophilia and systemic symptoms syndrome: a case report and literature review

in Predictive Toxicology

Zhe Zhao
Ming Lu
Yingqiu Ying

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1355774

4,752 views
4 citations

Original Research

Published on 07 Mar 2024

Next generation risk assessment: an ab initio case study to assess the systemic safety of the cosmetic ingredient, benzyl salicylate, after dermal exposure

in Predictive Toxicology

Johanna Ebmeyer
Abdulkarim Najjar
Daniela Lange
Mareike Boettcher
Silja Voß
Katrin Brandmair
Jaqueline Meinhardt
Jochen Kuehnl
Nicola J. Hewitt
Christopher-Tilman Krueger

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1345992

6,757 views
18 citations

Original Research

Published on 06 Mar 2024

Evaluation of the lncRNA-miRNA-mRNA ceRNA network in lungs of miR-147 −/− mice

in Predictive Toxicology

Nan Zhang
Gui-Yuan Song
Qing-Hua Yu
Xin-Ming Fan
Wen-Shuo Zhang
Yong-Jian Hu
Tian-Zhu Chao
Yao-Yao Wu
Shu-Yan Duan
Fei Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1335374

2,945 views
3 citations

Original Research

Published on 21 Feb 2024

Prediction of risk factors for linezolid-induced thrombocytopenia based on neural network model

in Predictive Toxicology

Xian Zhao
Qin Peng
Dongmei Hu
Weiwei Li
Qing Ji
Qianqian Dong
Luguang Huang
Miyang Piao
Yi Ding
Jingwen Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1292828

3,785 views
9 citations

Original Research

Published on 21 Feb 2024

Evaluation of the hepatotoxicity of Psoralea corylifolia L. based on a zebrafish model

in Predictive Toxicology

Shu-Yan Gao
Jing-Cheng Zhao
Qing Xia
Chen Sun
Maimaiti Aili
Ainiwaer Talifu
Shi-Xia Huo
Yun Zhang
Zhi-Jian Li

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1308655

4,673 views
8 citations

Case Report

Published on 26 Jan 2024

Case report: One case of refractory membranous nephropathy with hypokalemia after rituximab infusion was switched to obinutuzumab without recurrence of hypokalemia

in Predictive Toxicology

Yao Zhang
Jing Sun
Jie Gao
Weiyan Sun
Liang Xu
Chunjuan Zhai
WenYan Su
Haiping Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1347880

3,590 views
11 citations

Original Research

Published on 25 Jan 2024

Development and application of consensus in silico models for advancing high-throughput toxicological predictions

in Predictive Toxicology

Sean P. Collins
Brandon Mailloux
Sunil Kulkarni
Matthew Gagné
Alexandra S. Long
Tara S. Barton-Maclaren

Frontiers in Pharmacology

doi 10.3389/fphar.2024.1307905

4,730 views
10 citations

Original Research

Published on 14 Dec 2023

Moderate selenium mitigates hand grip strength impairment associated with elevated blood cadmium and lead levels in middle-aged and elderly individuals: insights from NHANES 2011–2014

in Predictive Toxicology

Yafeng Liang
Junqi Wang
Tianyi Wang
Hangyu Li
Chaohui Yin
Jialin Liu
Yulong Wei
Junxing Fan
Shixing Feng
Shuangqing Zhai

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1324583

8,580 views
10 citations

Case Report

Published on 23 Nov 2023

Case report: Severe respiratory failure caused by licorice

in Predictive Toxicology

Hiroaki Taniguchi
Takero Terayama
Nobuaki Kiriu
Hiroshi Kato
Soichiro Seno
Yasumasa Sekine
Yoshihiro Tanaka
Tetsuro Kiyozumi

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1289755

6,460 views
2 citations

Review

Published on 21 Nov 2023

Research progress in cardiotoxicity of organophosphate esters

in Predictive Toxicology

Hui Fang
Longfei Yang
Meng Yan
Yanan Fan
Jianping Zhu
Lizhen Ji

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1264515

3,449 views
2 citations

Case Report

Published on 31 Oct 2023

Torsade de pointes associated with long-term antiretroviral drugs in a patient with HIV: a case report

in Predictive Toxicology

Xuechun Mu
Yujiao Duan
Qiuhua Xu
Sa Wang
Guiju Gao
Ning Han
Hongxin Zhao

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1268597

2,777 views
2 citations

Original Research

Published on 14 Sep 2023

Safety assessment of fluorescently labeled anti-EGFR Nanobodies in healthy dogs

in Predictive Toxicology

Nayra Cristina Herreira do Valle
Simone Janssen
Marcus C. M. Stroet
Sofie Pollenus
Sonja Van den Block
Nick Devoogdt
Jens M. Debacker
Sophie Hernot
Hilde De Rooster

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1266288

5,318 views
5 citations

Original Research

Published on 06 Sep 2023

Integrating distribution kinetics and toxicodynamics to assess repeat dose neurotoxicity in vitro using human BrainSpheres: a case study on amiodarone

in Predictive Toxicology

Carolina Nunes
Susana Proença
Giovanna Ambrosini
David Pamies
Aurélien Thomas
Nynke I. Kramer
Marie-Gabrielle Zurich

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1248882

3,895 views
6 citations

Original Research

Published on 04 Sep 2023

Graph generative and adversarial strategy-enhanced node feature learning and self-calibrated pairwise attribute encoding for prediction of drug-related side effects

in Predictive Toxicology

Ping Xuan
Kai Xu
Hui Cui
Toshiya Nakaguchi
Tiangang Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1257842

2,731 views
5 citations

Original Research

Published on 17 Aug 2023

Using available in vitro metabolite identification and time course kinetics for β-chloroprene and its metabolite, (1-chloroethenyl) oxirane, to include reactive oxidative metabolites and glutathione depletion in a PBPK model for β-chloroprene

in Predictive Toxicology

J. L. Campbell
H. J. Clewell
C. Van Landingham
P. R. Gentry
M. E. Andersen

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1223808

2,202 views
1 citation

Original Research

Published on 11 Aug 2023

β-hydroxybutyrate impairs bovine oocyte maturation via pyruvate dehydrogenase (PDH) associated energy metabolism abnormality

in Predictive Toxicology

Kai-Yan Zhang
Jing Guo
Cheng-Lin Zhan
Chong-Shan Yuan
Chang-Guo Min
Zhi-Qiang Li
Hong-Yu Liu
Jun Wang
Jing Zhao
Wen-Fa Lu

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1243243

4,240 views
6 citations

Original Research

Published on 04 Aug 2023

Subacute toxicity evaluations of LPM3480392 in rats, a full µ-opioid receptor biased agonist

in Predictive Toxicology

Liang Ye
Chunmei Li
Wanglin Jiang
Yifei Yang
Wenyan Wang
Haibo Zhu
Zhengping Hu
Ning Li
Xiaobo Cen
Hongbo Wang

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1218380

5,904 views
2 citations

495 articles

articles

Effects of ranolazine on the arrhythmic substrate in hypertrophic cardiomyopathy

Exploiting the predictive power of educated spheroids to detect immune-mediated idiosyncratic drug-induced liver injury: the case of troglitazone

Case report: Paralytic ileus resulted from nirmatrelvir/ritonavir-tacrolimus drug-drug interaction in a systemic lupus erythematosus patient with COVID-19

Safety assessment of Acori Tatarinowii Rhizoma: acute and subacute oral toxicity

Emerging insights into the impacts of heavy metals exposure on health, reproductive and productive performance of livestock

Product labeling accuracy and contamination analysis of commercially available cannabidiol product samples

Post-marketing safety evaluation of lurbinectedin: a pharmacovigilance analysis based on the FAERS database

Case Report: Minocycline-induced drug reaction with eosinophilia and systemic symptoms syndrome: a case report and literature review

Next generation risk assessment: an ab initio case study to assess the systemic safety of the cosmetic ingredient, benzyl salicylate, after dermal exposure

Evaluation of the lncRNA-miRNA-mRNA ceRNA network in lungs of miR-147 −/− mice

Prediction of risk factors for linezolid-induced thrombocytopenia based on neural network model

Evaluation of the hepatotoxicity of Psoralea corylifolia L. based on a zebrafish model

Case report: One case of refractory membranous nephropathy with hypokalemia after rituximab infusion was switched to obinutuzumab without recurrence of hypokalemia

Development and application of consensus in silico models for advancing high-throughput toxicological predictions

Moderate selenium mitigates hand grip strength impairment associated with elevated blood cadmium and lead levels in middle-aged and elderly individuals: insights from NHANES 2011–2014

Case report: Severe respiratory failure caused by licorice

Research progress in cardiotoxicity of organophosphate esters

Torsade de pointes associated with long-term antiretroviral drugs in a patient with HIV: a case report

Safety assessment of fluorescently labeled anti-EGFR Nanobodies in healthy dogs

Integrating distribution kinetics and toxicodynamics to assess repeat dose neurotoxicity in vitro using human BrainSpheres: a case study on amiodarone

Graph generative and adversarial strategy-enhanced node feature learning and self-calibrated pairwise attribute encoding for prediction of drug-related side effects

Using available in vitro metabolite identification and time course kinetics for β-chloroprene and its metabolite, (1-chloroethenyl) oxirane, to include reactive oxidative metabolites and glutathione depletion in a PBPK model for β-chloroprene

β-hydroxybutyrate impairs bovine oocyte maturation via pyruvate dehydrogenase (PDH) associated energy metabolism abnormality

Subacute toxicity evaluations of LPM3480392 in rats, a full µ-opioid receptor biased agonist