Frontiers in Pharmacology | Predictive Toxicology

Original Research

Published on 02 Mar 2023

Physiologically based kinetic modeling of senecionine N-oxide in rats as a new approach methodology to define the effects of dose and endpoint used on relative potency values of pyrrolizidine alkaloid N-oxides

in Predictive Toxicology

Frances Widjaja
Liang Zheng
Sebastiaan Wesseling
Ivonne M. C. M. Rietjens

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1125146

2,265 views
7 citations

Original Research

Published on 22 Feb 2023

PBPK modeling to evaluate maximum tolerated doses: A case study with 3-chloroallyl alcohol

in Predictive Toxicology

Rory P. Conolly
Harvey J. Clewell
Martha M. Moore
Jerry L. Campbell
Wanyun Cheng
R. Robinan Gentry

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1088011

2,341 views
2 citations

Original Research

Published on 20 Feb 2023

Development, testing, parameterisation, and calibration of a human PBPK model for the plasticiser, di-(2-ethylhexyl) terephthalate (DEHTP) using in silico, in vitro and human biomonitoring data

in Predictive Toxicology

Kevin McNally
Craig Sams
Alex Hogg
George Loizou

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1140852

4,215 views
2 citations

Original Research

Published on 10 Feb 2023

Biosafety, histological alterations and residue depletion of feed administered anti-parasitic drug emamectin benzoate in golden mahseer, Tor putitora (Hamilton, 1822) as a model candidate fish for sport fishery and conservation in temperate waters

in Predictive Toxicology

Sumanta Kumar Mallik
Shivam Singh
Neetu Shahi
Prasanna Kumar Patil
Krishna Kala
Richa Pathak
Abhay Kumar Giri
Partha Das
Ritesh Shantilal Tandel
Suresh Chandra

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1106124

3,859 views
8 citations

Original Research

Published on 08 Feb 2023

Development of a microphysiological skin-liver-thyroid Chip3 model and its application to evaluate the effects on thyroid hormones of topically applied cosmetic ingredients under consumer-relevant conditions

in Predictive Toxicology

Thi-Phuong Tao
Ilka Maschmeyer
Edward L. LeCluyse
Eda Rogers
Katrin Brandmair
Silke Gerlach
Julia Przibilla
Fredy Kern
Camille Genies
Carine Jacques

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1076254

5,350 views
12 citations

Editorial

Published on 06 Feb 2023

Editorial: Toxicity mechanism and clinical features of PD-1/PD-l1 inhibitors in treatment of cancer, volume II

in Predictive Toxicology

Chuqi Lei
Xiangyi Kong
Ryan J. Sullivan
Caisheng Wu
Dawei Wang
Lin Zhang

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1136373

1,635 views

Original Research

Published on 02 Feb 2023

Pharmacological screening of silibinin for antischizophrenic activity along with its acute toxicity evaluation in experimental animals

in Predictive Toxicology

Qurat Ul Ain
Uzma Saleem
Bashir Ahmad
Iqra Khalid

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1111915

3,642 views
6 citations

Original Research

Published on 02 Feb 2023

Refinement and calibration of a human PBPK model for the plasticiser, Di-(2-propylheptyl) phthalate (DPHP) using in silico, in vitro and human biomonitoring data

in Predictive Toxicology

Kevin McNally
George Loizou

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1111433

2,405 views
3 citations

Original Research

Published on 26 Jan 2023

Fenchone, a monoterpene: Toxicity and diuretic profiling in rats

in Predictive Toxicology

Asifa Bashir
Muhammad Naveed Mushtaq
Waqas Younis
Irfan Anjum

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1119360

4,289 views
8 citations

Case Report

Published on 26 Jan 2023

Case report: An autopsy case of pilsicainide poisoning

in Predictive Toxicology

Sella Takei
Hiroshi Kinoshita
Mitsuru Kumihashi
Mostofa Jamal
Hiroko Abe
Shoji Kimura

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1090265

4,606 views
1 citation

Original Research

Published on 23 Jan 2023

Pharmacokinetics and biosafety evaluation of a veterinary drug florfenicol in rainbow trout, Oncorhynchus mykiss (Walbaum 1792) as a model cultivable fish species in temperate water

in Predictive Toxicology

Sumanta Kumar Mallik
Neetu Shahi
Richa Pathak
Krishna Kala
Prasanna Kumar Patil
Bhupendra Singh
Rajisha Ravindran
Nanitha Krishna
Pramod Kumar Pandey

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1033170

4,781 views
17 citations

Original Research

Published on 23 Jan 2023

Nephroprotective potential of Polyalthia longifolia roots against vancomycin-induced renal toxicity in experimental animals

in Predictive Toxicology

Kuntal Das
A. Muthukumar
Mansour Almuqbil
Mohd. Imran
Ali A. Rabaan
Muhammad A. Halwani
Mohammed Garout
Abdulmonem A. Alsaleh
Mohammed Alissa
Ameen S. S. Alwashmi

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1107435

3,201 views
2 citations

Original Research

Published on 19 Jan 2023

Characterization of pathological remodeling in the chronic atrioventricular block cynomolgus monkey heart

in Predictive Toxicology

Hiroko Izumi-Nakaseko
Kengo Sakamoto
Ai Goto
Ryuichi Kambayashi
Akio Matsumoto
Yoshinori Takei
Akira Takahara
Atsushi Sugiyama

Frontiers in Pharmacology

doi 10.3389/fphar.2023.1055031

2,437 views
1 citation

Original Research

Published on 16 Jan 2023

Curcumin and cinnamon mitigates lead acetate-induced oxidative damage in the spleen of rats

in Predictive Toxicology

Mahmoud Abdelghaffar Emam
Sameh Mohamed Farouk
Ahmed Aljazzar
Abeer A. Abdelhameed
Abeer A. Eldeeb
Fatma Abdel-monem Gad

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1072760

4,419 views
9 citations

Editorial

Published on 11 Jan 2023

Editorial: Toxicity mechanisms, exposure, toxicokinetic and risk assessment aspects of metals, toxic for animals and humans, Volume II

in Predictive Toxicology

Yanzhu Zhu
Fatma M. El-Demerdash
Xu Yang
Alex Boye
Michel Mansur Machado
Xinwei Li

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1107327

1,207 views

Case Report

Published on 23 Dec 2022

A case report of severe pirimiphos-methyl intoxication: Clinical findings and cholinesterase status

in Predictive Toxicology

Tobias Zellner
Christian Rabe
Jens von der Wellen-Pawlowski
Dagmar Hansen
Harald John
Franz Worek
Florian Eyer

Frontiers in Pharmacology

doi 10.3389/fphar.2022.1102160

3,662 views
2 citations