Frontiers in Psychiatry | Molecular Psychiatry

Original Research

Published on 12 May 2025

Unveiling chiral amino acid alterations and glycine dysregulation in late-life depression through targeted metabolomics

in Molecular Psychiatry

Mingxia Liu
Weigang Pan
Jing He
Sihai Ling
Yi He
Jian Yang
Peixian Mao
Zuoli Sun

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1558796

146 views

Systematic Review

Published on 29 Apr 2025

Translational interdisciplinary research on human chorionic gonadotropin’s enhancement of neuroendocrine crosstalk: a novel medical hypothesis for systemic adjunctive treatment of psychiatric disorders

in Molecular Psychiatry

João Francisco Pollo Gaspary
Luis Felipe Dias Lopes
Antonio Geraldo Camara

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1537442

314 views

Original Research

Accepted on 25 Apr 2025

Association between GRIN2B DNA methylation and cognitive impairment: a cross-sectional study of patients with bipolar depression

in Molecular Psychiatry

Hao Yu
Chengji Wang
Yao Wu
Changxing He
Zou Shaohong

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1574391

169 views

Original Research

Published on 22 Apr 2025

Genetic association between gene expression profiles in oligodendrocyte precursor cells and psychiatric disorders

in Molecular Psychiatry

Reon Kondo
Hiroki Kimura
Masashi Ikeda

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1566155

817 views

Original Research

Accepted on 14 Apr 2025

Exosomal microRNA signatures in youth at clinical high risk for bipolar disorder

in Molecular Psychiatry

Xinyu Meng
Shengmin Zhang
Yingzhen Xu
Zaohui Ma
Shuzhe Zhou
Yantao Ma
Hong Ma
Xin Yu
Lili Guan

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1589374

101 views

Editorial

Published on 10 Apr 2025

Editorial: The individual and joint contributions of molecular and environmental factors on gene expression and psychopathology development

in Molecular Psychiatry

Gabriela Ariadna Martínez-Levy
Diego Luiz Rovaris
Rodrigo G. Arzate-Mejía
Jill A. Rabinowitz

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1599378

489 views

Original Research

Published on 21 Mar 2025

Sentence-level multi-modal feature learning for depression recognition

in Molecular Psychiatry

Guanghua Zhang
Guangping Zhuo
Yang Yang
Guohua Xu
Shukui Ma
Hao Liu
Zhiyong Ren

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1439577

721 views

Review

Published on 18 Mar 2025

Knowledge graph and its application in the study of neurological and mental disorders

in Molecular Psychiatry

Qizheng Wang
Fan Yang
Lijie Quan
Mengjie Fu
Zhongli Yang
Ju Wang

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1452557

1,350 views

Original Research

Published on 12 Mar 2025

Interplay between polygenic risk and family processes in predicting trajectories of adolescent externalizing behaviors

in Molecular Psychiatry

Jinni Su
Belal Jamil
Kit K. Elam
Angel D. Trevino
Kathryn Lemery-Chalfant
Eleanor K. Seaton
Rick A. Cruz
Kevin J. Grimm

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1505035

870 views

Original Research

Published on 27 Feb 2025

LncRNA of peripheral blood mononuclear cells: HYMAI acts as a potential diagnostic and therapeutic biomarker for female major depressive disorder

in Molecular Psychiatry

Tianyi Bu
Jiarun Yang
Jiawei Zhou
Yeran Liu
Kexin Qiao
Yan Wang
Jili Zhang
Erying Zhao
Boakye Kwame Owura
Xiaohui Qiu

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1241089

667 views

Original Research

Published on 20 Feb 2025

Proteome analysis of the prefrontal cortex and the application of machine learning models for the identification of potential biomarkers related to suicide

in Molecular Psychiatry

Manuel Alejandro Rojo-Romero
Nora Andrea Gutiérrez-Nájera
Carlos Sabás Cruz-Fuentes
Ana Luisa Romero-Pimentel
Roberto Mendoza-Morales
Fernando García-Dolores
Mirna Edith Morales-Marín
Xóchitl Castro-Martínez
Elier González-Sáenz
Jonatan Torres-Campuzano

Frontiers in Psychiatry

doi 10.3389/fpsyt.2024.1429953

1,810 views

Original Research

Published on 18 Feb 2025

Utilizing metagenomic profiling and machine learning model to identify bacterial biomarkers for major depressive disorder

in Molecular Psychiatry

Xuan Wang
Di Cao
Hanlin Zhang
Wei Chen
Jiaxin Sun
Huimin Hu

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1539596

1,182 views

Original Research

Published on 14 Feb 2025

Assessing the feasibility of using salivary microRNAs as biomarkers to distinguish between chronic stress and childhood trauma in African American young women in an exploratory pilot study

in Molecular Psychiatry

Erica Holliday
Anisah Bagasra
Omar Bagasra
Pratima Pandey

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1507064

910 views

Original Research

Published on 13 Feb 2025

Impact of life adversity and gene expression on psychiatric symptoms in children and adolescents: findings from the Brazilian high risk cohort study

in Molecular Psychiatry

Vanessa Kiyomi Ota
Adrielle Martins Oliveira
Amanda Victória Gomes Bugiga
Helena B. Conceição
Pedro Alexandre Favoretto Galante
Paula Fontes Asprino
Julia Luiza Schäfer
Mauricio Scopel Hoffmann
Rodrigo Bressan
Elisa Brietzke

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1505421

1,826 views
1 citation

Original Research

Published on 30 Jan 2025

NEK4: prediction of available drug targets and common genetic linkages in bipolar disorder and major depressive disorder

in Molecular Psychiatry

Bin Gong
Chenxu Xiao
Yu Feng
Jing Shen

Frontiers in Psychiatry

doi 10.3389/fpsyt.2025.1414015

1,734 views

Original Research

Published on 29 Jan 2025

Trace amine-associated receptors (TAARs)2-9 knockout mice exhibit reduced wakefulness and disrupted REM sleep

in Molecular Psychiatry

Sunmee Park
Jasmine Heu
Gavin Scheldrup
Ryan K. Tisdale
Yu Sun
Meghan Haire
Shun-Chieh Ma
Marius C. Hoener
Thomas S. Kilduff

Frontiers in Psychiatry

doi 10.3389/fpsyt.2024.1467964

1,234 views