ORIGINAL RESEARCH article
Front. Public Health
Sec. Children and Health
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1527569
Global, regional, and national burdens of pancreatitis in children and adolescents aged 0-24 years from 1992 to 2021: a trend analysis based on the Global Burden of Disease Study 2021
Provisionally accepted
- 1Sanming First Hospital, Fujian Medical University, Sanming, China
- 2The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian Province, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background:The younger onset of pancreatitis presents a significant public health challenge. This study aims to analyze the global burden of pancreatitis in younger populations based on the Global Burden of Disease 2021.Methods:This study uses incidence rates and Disability-Adjusted Life Years (DALYs) to assess the burden of pancreatitis. Joinpoint modeling was used to assess the trend of the burden. Age-Period-Cohort (APC) modeling was used to assess the annual percentage changes by age, as well as the period and cohort relative risks. Norpred modeling was used to predict the burden through 2040.Results:In 2021, the global incidence of pancreatitis among younger individuals was 9.16/100,000 (95% UI 5.74-13.85), with an annual average percentage change (AAPC) of 0.13 (95% CI 0.12-0.14). The DALYs was 6.36/100,000 (95% UI 5.21-7.97), with an AAPC of -0.93 (95% CI -1.01 to -0.85). Global incidence rates of pancreatitis have notably increased since 1999, while the overall burden of DALYs has decreased over the past 30 years. In the APC model, different age groups experienced varying risks. According to the Norpred predictive model, by 2040, the global incidence of pancreatitis among younger individuals is projected to reach 313,567 cases, with an incidence rate of 9.07/100,000.Globally, the incidence of pancreatitis in younger individuals has increased over the past three decades. Urgent policy interventions are needed to address healthcare inequities and alleviate this burden.
Keywords: Pancreatitis, Burden, Children, adolescents, Acute pancreatis, Chronic pancreaititis
Received: 13 Nov 2024; Accepted: 27 May 2025.
Copyright: © 2025 Deng, Qiu, Huang, Huang, Lian, Chen and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hongbin Chen, Sanming First Hospital, Fujian Medical University, Sanming, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.