ORIGINAL RESEARCH article
Front. Public Health
Sec. Radiation and Health
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1535155
This article is part of the Research TopicRecent Studies on the Use of Magnetic Fields in Experimental Oncology: Effects of Magnetic Fields on Cancer BiologyView all articles
The Proliferation Rates of HT-1080 Human Fibrosarcoma Cells Can Be Accelerated or Inhibited by Weak Static and Extremely Low Frequency Magnetic Fields
Provisionally accepted
Marek Bajtoš1
Nhat Dang2*
Isabel Lopez De Mingo3,4
Jason Keller2
Hakki Gurhan2Ladislav Janoušek1
Frank Barnes2- 1University of Žilina, Žilina, Slovakia
- 2University of Colorado Boulder, Boulder, United States
- 3Centro de Tecnología Biomédica, Universidad Politécnica de Madrid, Madrid, Madrid, Spain
- 4Escuela Técnica Superior de Ingenieros de Caminos, Canales y Puertos, Universidad Politécnica de Madrid, Madrid, Madrid, Spain
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This study presents experimental findings demonstrating that weak static and low-frequency magnetic fields (MFs) can alter the growth rates of HT-1080 fibrosarcoma cells in vitro, accompanied by a theoretical explanation of possible underlying mechanisms. Results indicate that weak MFs can both increase and decrease the growth rates of fibrosarcoma and fibroblast cells in addition to altering mitochondrial superoxide (O2-) and calcium ion (Ca2+) concentrations. These effects are hypothesized to arise from changes in chemical reaction rates mediated by changes in nuclear spin coupling. The growth rates of fibrosarcoma cells were significantly modulated during 4-day exposures to MFs with a 10 μT amplitude and frequencies between 12 Hz and 33 Hz, superimposed on a 45 μT static background field. Growth rates were highly sensitive to small variations in frequency and amplitude, near postulated oscillations of nuclear spin orientations. Inversions in growth rates are observed at 16.5 Hz for changes of 0.5 Hz. Near this frequency, amplitude changes as small as 250 nT reversed growth rates compared to controls at 45 μT. Additionally, inverting the static magnetic field led to an inversion of growth rate effects relative to controls. Further data reveal concurrent changes in membrane potential, Ca2+ concentrations, and mitochondrial superoxide levels, emphasizing the role of cellular bioenergetics in MF-induced growth modulation. Differences between normal and diseased tissues offers potential therapeutic applications.
Keywords: Weak magnetic fields, J coupling, Fibrosarcoma cells, cell growth, feedback effect, Time-delay effect, resonance frequencies
Received: 26 Nov 2024; Accepted: 29 May 2025.
Copyright: © 2025 Bajtoš, Dang, Lopez De Mingo, Keller, Gurhan, Janoušek and Barnes. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Nhat Dang, University of Colorado Boulder, Boulder, United States
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