ORIGINAL RESEARCH article
Front. Public Health
Sec. Environmental Health and Exposome
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1545872
Association between combined urinary phthalate metabolites exposure and Grip strength among residents in Guangzhou, China
Provisionally accepted
- 1Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases, Guangzhou, China
- 2KingMed School of Laboratory Medicine, Guangzhou Medical University, Guangzhou, Guizhou Province, China
- 3Guangzhou Center for Disease Control and Prevention, Guangzhou, China
- 4Guangzhou Medical University, Guangzhou, Guangdong Province, China
- 5Guangzhou Conghua District Center for Disease Control and Prevention, Guangzhou, China
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Background: Exposure to environmental phthalate metabolites (mPAEs) has been suggested to potentially affect grip strength, either directly or indirectly. however, research on the impact of mPAEs mixtures on grip strength remains limited. This study aimed to investigate the independent and joint effects of co-exposure to multiple mPAEs on grip strength among residents of Guangzhou, China.Methods: Data were collected from 972 participants, and urinary concentrations of nine mPAEs (mMP, mEP, miBP, mnBP, mCHP, mEOHP, mEHHP, mBzP, and mEHP) were measured. To assess these relationships, we conducted Generalized linear regression models, Bayesian Kernel Machine Regression (BKMR), and Weighted Quantile Sum (WQS) regression analyses.The Results showed that higher quartiles of mMP, miBP, mCHP, mEHHP, and mEHP were associated with decreased grip strength compared to the first quartile (Q1):
Keywords: mPAEs, Phthalates, Grip strength, Combined effects, BKMR mMP (Q4 vs. Q1: β = -1.44, 95% CI: -2.65 to -0.23, P = 0.019), miBP (Q2 vs. Q1: β = -1.78, 95% CI: -2.956 to -0.61, P = 0.003, Q3 vs. Q1: β = -1.39, 95% CI: -2.57 to -0.21, P = 0.002, Q4 vs. Q1: β = -1.23, 95% CI: -2.43 to 0.03, P = 0.045), mCHP (Q2 vs. Q1: β = -1.20, 95% CI: -2.38 to -0.03, P = 0.043), mEHHP (Q3 vs
Received: 16 Dec 2024; Accepted: 29 Apr 2025.
Copyright: © 2025 Chen, Shi, Xu, Feng, Lv, Shi and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Tongxing Shi, Guangzhou Center for Disease Control and Prevention, Guangzhou, 510440, China
Qinqin Jiang, Guangzhou Center for Disease Control and Prevention, Guangzhou, 510440, China
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