ORIGINAL RESEARCH article

Front. Public Health

Sec. Infectious Diseases: Epidemiology and Prevention

Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1557678

This article is part of the Research TopicAdvancements in HPV Research: Integrating Diagnostics, Vaccination, and Women's HealthView all 4 articles

A Study of HPV Self-Sampling by Female Residents in Communities of Zhengzhou, Henan Province, China: A cross-sectional observational study

Provisionally accepted
Yang ZheYang Zhe1,2,3,4Yue LuYue Lu3Yiping ZhangYiping Zhang2Yunfeng ZhangYunfeng Zhang2Jingyi MuJingyi Mu1,2,4Yicheng LiYicheng Li2Shihao MeiShihao Mei1,2Yuru GuoYuru Guo1,3Wanyue ZhangWanyue Zhang1,3Peiru ZhuPeiru Zhu1,4Yongjie LiYongjie Li1,2,3,4Guiqin ChenGuiqin Chen1,2,3,4Ruijiao ZhaoRuijiao Zhao1Aixia HuAixia Hu1Rujia FanRujia Fan1,2,3,4Yue WangYue Wang1,2,3,4*
  • 1Department of Gynecology and Obstetrics, Henan Provincial People's Hospital, Zhengzhou, Henan Province, China
  • 2Department of Obstetrics and Gynecology, People's Hospital of Zhengzhou University, Zhengzhou, China
  • 3Department of Obstetrics and Gynecology, People's Hospital of Henan University, Zheng Zhou, China
  • 4Henan International Joint Laboratory of Early Diagnosis and Treatment of Gynecological Malignant Tumors, Zhengzhou, China

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Objective: Evaluate the feasibility of HPV self-sampling typing and quantitative detection as a cervical cancer screening scheme, and provide new methods to reduce the incidence of cervical cancer.Methods: This was a cross-sectional observational study of 1,228 female residents in communities in Zhengzhou city, Henan Province, who participated in HPV self-sampling detection. All the samples were subjected to HPV typing and quantitative detection. HPV-positive individuals were recalled for further cervical liquid-based cytology and colposcopy.The results of this study revealed that 33.71% of female residents lacked awareness of cervical cancer screening. Older age and low educational level are independent influencing factors for the lack of screening awareness. The overall positive rate of HPV was 18.89%. The three most common subtypes were types 16 (2.61%), 52 (2.44%), and 53 (2.28%). Results revealed that age at first sexual intercourse, sexual frequency, parity, having multiple sexual partners, cleaning behavior after sexual intercourse, and using condoms during sexual intercourse were factors related to HPV infection (P<0.05). Logistic regression analysis revealed that age at first sexual intercourse ≤20 years, sexual frequency >2 times/week, parity >1 time, and having multiple sexual partners were risk factors for HPV infection (OR>1, P<0.05). Frequent cleaning after sexual intercourse and frequent use of condoms during sexual intercourse were protective factors against HPV infection (OR<1, P<0.05).HPV self-sampling detection had a good experience and a high degree of acceptance, which can be promoted and applied in cervical cancer screening in Henan province.

Keywords: cervical cancer, HPV self-sampling, communities, Early Screening, HPV typing and quantitative

Received: 09 Jan 2025; Accepted: 10 Jun 2025.

Copyright: © 2025 Zhe, Lu, Zhang, Zhang, Mu, Li, Mei, Guo, Zhang, Zhu, Li, Chen, Zhao, Hu, Fan and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Yue Wang, Department of Gynecology and Obstetrics, Henan Provincial People's Hospital, Zhengzhou, Henan Province, China

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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