ORIGINAL RESEARCH article
Front. Public Health
Sec. Disaster and Emergency Medicine
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1560587
Incorporation of oXiris Bioabsorbent Filter to CRRT in the Treatment of Severe Abdominal Infections and Analysis of Associated Risk Factors for Early Off-Machine
Provisionally accepted
- First Affiliated Hospital of Fujian Medical University, Fuzhou, China
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This study aims to evaluate the impact of oXiris continuous renal-replacement therapy (CRRT) on the prognosis of patients with severe intra-abdominal infections and to analyze potential risk factors for early off-machine of oXiris CRRT during treatment.Methods: 49 patients with severe abdominal infections admitted to the intensive care unit of the First Affiliated Hospital of Fujian Medical University from October 2020 to October 2023 were retrospectively analyzed. They were divided into conventional and oXiris groups, and heart rate, blood lactate level, mean arterial pressure, and total CRRT operation time were observed 72 hours before and after CCRT treatment.Results:Comparing the changes in indicators over the 72-hour period between the two groups, there was no significant difference in the survival rate between the two groups. D-dimer (per 1 ng/mL increase, OR = 0.930, 95% CI: 0.866-0.999) was a risk factor for early off-machine, whereas prothrombin time (PT, per 1-second increase, OR = 1.117, 95% CI: 1.017-1.226), activated partial thrombo-plastin time (APTT, per 1-second increase, OR = 1.021, 95% CI: 1.006-1.037), and blood flow velocity (per 1 mL/min increase, OR = 1.027, 95% CI: 1.009-1.046) were protective factors.:oXiris CRRT has a better prognosis in the treatment of severe abdominal infections, and APTT, PT, D-dimer, and blood flow velocity are associated risk factors leading to early off-machine during oXiris CRRT.
Keywords: early off-machine, Risk factors, severe abdominal infections, oXiris Bioabsorbent Filter, CRRT
Received: 14 Jan 2025; Accepted: 11 Jul 2025.
Copyright: © 2025 LI, Chen, Wu, Zhang and DONG. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yiming LI, First Affiliated Hospital of Fujian Medical University, Fuzhou, China
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