MINI REVIEW article
Front. Public Health
Sec. Children and Health
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1568140
This article is part of the Research TopicThe Impact of Non-Communicable Diseases on Maternal Health and Pregnancy OutcomesView all articles
The impact of maternal systemic diseases on the occurrence of cleft lip and palate in newborns: a narrative review
Provisionally accepted
- West China School of Stomatology, Sichuan University, Chengdu, China
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Cleft lip and palate (CLP) is a prevalent congenital anomaly of the maxillofacial region, characterized by abnormal openings in the lip or palate. This condition, affecting approximately 1 in 700 newborns globally, can manifest as cleft lip only, cleft palate only, or both. The etiology of CLP remains multifactorial, involving genetic and environmental influences, with maternal systemic diseases during pregnancy emerging as significant risk factors. Conditions such as circulatory disorders, endocrine and metabolic disorders, infectious diseases, and autoimmune diseases have been associated with increased CLP incidence. These maternal health issues can disrupt normal embryonic development, leading to cleft formation and affecting the child's overall well-being, including feeding, speech, dental health, and psychological state. This review explores the relationship between maternal systemic diseases, including circulatory, endocrine, infectious, and autoimmune disorders, and the occurrence of CLP in newborns. Understanding these connections is crucial for improving maternal health during pregnancy and reducing the risk of CLP, highlighting the importance of early monitoring and intervention.
Keywords: clp, maternal, Pregnancy, Systemic diseases, Risk factors
Received: 05 Feb 2025; Accepted: 21 Jul 2025.
Copyright: © 2025 Sui, Du, Chen, Yang, Shi, Huang and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Hanyao Huang, West China School of Stomatology, Sichuan University, Chengdu, China
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