ORIGINAL RESEARCH article
Front. Public Health
Sec. Health Economics
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1570792
Global, Regional, and National Economic Burden of Hematologic Malignancies (1990-2021) with Projections to 2050
Provisionally accepted
Li Luo*
Guangpeng Chen- Fudan University, Shanghai, China
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Background Hematologic malignancies (HM) impose substantial healthcare and productivity-related costs globally. However, disparities in economic impact across regions and countries remain insufficiently explored. This study aimed to evaluate the global, regional, and national economic burden of HM and its subtypes (leukemia, non-Hodgkin lymphoma, multiple myeloma, and Hodgkin lymphoma) from 1990 to 2021, with projections to 2050.Methods Data from the Global Burden of Disease 2021 study were utilized to estimate the economic burden of HM using the value of a statistical life year (VSLY) approach, based on disability-adjusted life years (DALYs). Decomposition analysis was conducted to identify drivers of economic burden, including population growth and aging. Future trends were modeled using the Bayesian Age-Period-Cohort (BAPC) model, and comparisons of economic burden were made across countries by income levels.In 2021, the global economic burden of HM reached $1.516 trillion, a 52.8% increase from $992 billion in 1990. This represented approximately 1% of the global GDP, with high-income countries (HICs) bearing the largest share of 2.17% of GDP, compared to 0.58% in lower-middleincome countries (LMICs).
Keywords: Global burden of disease, hematologic malignancies, economic burden, Hodgkin lymphoma, Leukemia, Multiple Myeloma, non-Hodgkin lymphoma
Received: 04 Feb 2025; Accepted: 08 May 2025.
Copyright: © 2025 Luo and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Li Luo, Fudan University, Shanghai, China
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