The Resurgence of Lassa Fever in Nigeria: Economic Impact, Challenges, and Strategic Public Health Interventions

Stanley Chinedu Eneh^1,2*Chidera Gabriel Obi³Ephraim Udokang⁴Zakariya'u Dauda⁵Samson Adiaetok Udoewah⁶Collins Chibueze Anokwuru⁷Francisca Ogochukwu Onukansi⁷Ogechi Vinaprisca Ikhuoria⁸Temitope Olumuyiwa Ojo²Chukwuocha Uchechukwu Madukaku⁹Ibuchukwu Nkeonyenasoya Orabueze^10,11Amara Frances Chizoba¹²

• ¹Ivan Research Institute, University of Nigeria, Enugu, Nigeria
• ²Department of Community Health, Faculty of Clinical Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria
• ³Department of Parasitology and Entomology, Nnamdi Azikiwe University, Awka, Nigeria
• ⁴Faculty of Pharmacy, University of Uyo, Uyo, Nigeria
• ⁵School of Medical Laboratory Science, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria
• ⁶Department of Public Health Nursing, Africa Centre of Excellence in Public Health and Toxicological Research, University of, Port Harcourt, Nigeria
• ⁷Department of Public Health, Federal University of Technology Owerri, Owerri, Imo State, Nigeria
• ⁸School of Public Health, University of Port Harcourt, Port Harcourt, Nigeria
• ⁹Innovations and Technologies for Disease Control Research Group, Department of Public Health, Federal University of Technology, Owerri, Imo state, Nigeria
• ¹⁰Department of Medical Microbiology, Faculty of Basic Clinical Sciences, College of Medicine, University of Nigeria, Ituku-Ozalla Campus, Enugu, Nigeria
• ¹¹Department of Microbiology, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria
• ¹²Mission to Elderlies Foundation, Anambra, Nigeria

Lassa fever remains a persistent public health challenge in Nigeria, with annual outbreaks expanding across the country. Between 2018 and 2023, the disease spread from 20 to 34 of Nigeria's 37 states, underscoring its endemic nature. Recent data from the Nigeria Centre for Disease Control and Prevention (NCDC) indicates 1171 suspected cases, 290 confirmed cases, and 53 deaths between January 6 to 26, 2025, with a case fatality rate of 18.3%. Lassa fever transmission is highly seasonal, peaking during the dry months when food scarcity drives rodenthuman interactions. Inadequate early detection, weak surveillance systems, and economic constraints exacerbate the burden on Nigeria's healthcare infrastructure. Environmental, socioeconomic, and systemic healthcare limitations drive the resurgence of Lassa fever. Climate change-induced shifts in temperature and precipitation patterns have disrupted rodent habitats, increasing human exposure to the virus. Additionally, poverty, poor sanitation, and urban expansion facilitate the proliferation of disease-carrying rodents. Limited funding and insufficient healthcare facilities hinder timely responses, contributing to high mortality rates. The economic impact extends beyond healthcare costs to agricultural disruptions, trade restrictions, and workforce productivity losses. To mitigate future outbreaks, Nigeria must adopt a multifaceted strategy that includes robust disease surveillance, the use of environmental data, effective rodent control measures, improved waste management, and strengthened cross-sectoral collaboration and policy implementation. Strengthening healthcare infrastructure, investing in vaccine development will enhance early detection and response efforts. By adopting an integrated One Health approach, Nigeria can improve disease control, reduce fatalities, and alleviate the economic burden of Lassa fever outbreaks.