ORIGINAL RESEARCH article
Front. Public Health
Sec. Aging and Public Health
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1577138
Reducible Burden of Laryngeal Cancer in Men Aged 50 and Older Attributable to Smoking and Alcohol Use: Insights from the Global Burden of Disease Study 2021
Provisionally accepted
- First Hospital of Jiaxing, Jiaxing, China
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Background: Smoking, alcohol use, advanced age, and male gender are well-established risk factors for laryngeal cancer. As smoking and alcohol consumption are modifiable behaviors, the burden of laryngeal cancer attributable to these factors is potentially reducible. This study aims to quantify the global, regional and national burden of laryngeal cancer attributable to smoking and alcohol use in men aged 50 years and older, assess temporal trends from 1990 to 2021, and project the disease burden through 2040.The burden of laryngeal cancer was assessed using data from the Global Burden of Disease 2021, including deaths, disability-adjusted life years (DALYs), years of life lost (YLLs), and years lived with disability (YLDs). The estimated average percentage change (EAPC) was used to evaluate trends in the disease burden from 1990 to 2021. Finally, projections for 2040 were generated and calculated with Nordpred.Results: From 1990 to 2021, globally, the absolute burden of laryngeal cancer-measured by deaths, DALYs, YLLs, and YLDs-attributable to smoking and alcohol use increased among men aged 50 years and older, despite declining age-standardized rates (ASRs). Regionally, Central and Eastern Europe experienced the highest burden, which may be attributed to historically elevated rates of smoking and alcohol consumption in these regions. Countries with the greatest disease burden related to smoking at ` the national level include Cuba, Montenegro, Seychelles, Georgia, and Monaco, while Montenegro, Bulgaria, Romania, and Monaco have the highest alcohol-related burden. By 2040, the overall burden is projected to rise.Smoking and alcohol-related laryngeal cancer will pose a significant public health challenge in the future. As the aging demographic continues to grow, the disease burden among elderly men is expected to rise. There are notable regional and national differences in terms of deaths, DALYs, YLLs, and YLDs. To address the rising burden, targeted public health actions are urgently required. These include higher taxation on tobacco and alcohol, comprehensive bans on related advertising, stricter enforcement of sales and age restrictions, enhanced health education regarding their health risks, and strengthened efforts in early screening.
Keywords: Laryngeal cancer, Smoking, alcohol use, Men, Global burden disease
Received: 15 Feb 2025; Accepted: 27 May 2025.
Copyright: © 2025 Chen, Deng, Sun, Sun, Lu and Sima. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Guoqi Sima, First Hospital of Jiaxing, Jiaxing, China
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