ORIGINAL RESEARCH article
Front. Public Health
Sec. Aging and Public Health
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1580340
This article is part of the Research TopicBiological Markers of Healthy AgingView all 4 articles
Association Between Atherogenic Index of Plasma and Physical Dysfunction: A Cross-Sectional Study of Middle-Aged and Elderly Adults in China
Provisionally accepted
- 1Tianjin Medical University, Tianjin, China
- 2Tianjin Third Central Hospital, Tianjin, China
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Background:Physical dysfunction is common in older adults and increases disease risk. The atherogenic index of plasma (AIP) is a promising biomarker for this condition. This study explored the dose–response relationship between AIP and physical dysfunction.Methods:Data from 11,369 CHARLS participants (aged ≥45 years) in 2015 and 2018 were analyzed using univariate and multivariate logistic regression, adjusting for demographics and lifestyle factors. The restricted cubic splines were used to examine possible non-linear associations and visualize the dose–response relationship between AIP and physical dysfunction. ROC curve analysis assessed AIP’s predictive performance, and subgroup analyses evaluated interactions.Results:Each interquartile range (IQR) increase in AIP was associated with a 13.4% higher odds of physical dysfunction (adjusted OR = 1.134, 95% CI: 1.066–1.207, P < 0.001), with a dose-response threshold identified at an AIP value of approximately 0.37. Beyond this threshold, the odds of physical dysfunction increased steadily, confirming a non-linear relationship. AIP exhibited moderate predictive accuracy for physical dysfunction (AUC = 0.748, 95% CI: 0.738–0.758). Stratified analysis showed AIP was significantly linked to higher physical dysfunction risk in subgroups including those aged <65, females, married individuals, high school or college-educated, rural residents, non-smokers, and non-drinkers (P<0.05), with no significance in other subgroups. Interaction analysis identified marital status (P=0.035) and education level (P=0.034) as significant effect modifiers, where subgroup differences notably altered the AIP-dysfunction association, warranting further study.Conclusion:Elevated AIP is significantly associated with increased physical dysfunction risk, highlighting its potential as a simple, predictive biomarker.Keywords: Atherogenic Index of Plasma, Physical Dysfunction, Restricted Cubic Spline Regression, Cross-Sectional Study, Elderly Population, Lipid Metabolism
Keywords: Atherogenic index of plasma, Physical dysfunction, Restricted cubic spline regression, Cross-sectional study, elderly population, Lipid Metabolism
Received: 20 Feb 2025; Accepted: 16 May 2025.
Copyright: © 2025 Zhou, Chang, Shen, Zhang, Wang, Liang and Gao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Wenqing Gao, Tianjin Medical University, Tianjin, China
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