ORIGINAL RESEARCH article
Front. Public Health
Sec. Aging and Public Health
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1584293
Negative Correlation Between Relative Fat Mass and Bone Mineral Density: NHANES 2011-2018
Provisionally accepted
- Zhejiang Taizhou Hospital, Taizhou, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Utilizing data from the National Health and Nutrition Examination Survey (NHANES), this study investigated the association between Relative Fat Mass (RFM) and lumbar spine bone mineral density (BMD) in adults, specifically evaluating the impact of RFM on lumbar BMD and determining the consistency of this relationship across diverse populations. Methods: Cross-sectional data from 9,238 adults aged ≥20 years in the 2011-2018 NHANES cycles were analyzed. Relative fat mass (RFM) values were derived through a formula incorporating waist circumference (WC) and height. The relationship between RFM and lumbar BMD was assessed through weighted multiple linear regression models, subgroup analyses, and smooth curve fitting. Results: After adjusting for multiple covariates, RFM exhibited a statistically significant inverse relationship with lumbar spine BMD. In the fully adjusted model, a per-unit increment in RFM was linked to a decline of 0.0110 g/cm² in lumbar BMD (β = -0.0110, 95% CI: -0.0132 to -0.0088; P < 0.0001). Additionally, an inflection point was detected at RFM = 20.5847 (P < 0.001), with significantly distinct correlations between RFM and lumbar spine BMD when values were above or below this point. Subgroup analyses confirmed the persistence of this inverse relationship in virtually all population subgroups stratified by demographic characteristics or health statuses. Conclusions: The analysis reveals a notable inverse relationship between RFM values 2 and BMD measurements in the lumbar spine, suggesting that elevated RFM levels might correlate with reduced BMD and heightened susceptibility to osteoporosis (OP) development. These observations highlight the critical role of evaluating adipose distribution patterns when devising preventive measures against OP and support employing RFM as an potential indicator for initiating early clinical interventions aimed at mitigating bone density deterioration.
Keywords: Relative Fat Mass (RFM), Bone Mineral Density (BMD), Osteoporosis (OP), NHANES, Obesity
Received: 27 Feb 2025; Accepted: 18 Jun 2025.
Copyright: © 2025 Jiang, Zhang, Ye, Fang, Zhang, Yu and Liang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Xingan Jiang, Zhejiang Taizhou Hospital, Taizhou, China
Jun-Bo Liang, Zhejiang Taizhou Hospital, Taizhou, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.