ORIGINAL RESEARCH article
Front. Public Health
Sec. Children and Health
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1592358
This article is part of the Research TopicEnvironmental Risk Factors and Psychosomatic DisordersView all 4 articles
Paternal Separation as an Independent Risk Factor for Irritable Bowel Syndrome in Rural Chinese Left-Behind Children: A Multicenter Cross-Sectional Study
Provisionally accepted
- 1The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
- 2Shaanxi Provincial People's Hospital, Xi'an, Shaanxi Province, China
- 3Xi'an Jiaotong University, Xi'an, China
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No study has assessed the relationship between separation factors and irritable bowel syndrome (IBS). We assess the association between the separation factors and IBS in Chinese leftbehind children (LBC). Methods: In this school-based study, we analyzed data from eight representative primary and secondary schools to assess the association between separation factors and IBS in Chinese LBC based on the Rome IV criteria. While individual-level income data were unavailable, all analyses were adjusted for regional socioeconomic disparities (Guanzhong Basin vs. Northern Shaanxi vs. Southern Shaanxi). Results: A total of 349 IBS and 7355 non-IBS children were included, and the proportion of LBC was 21.13%. Univariate analysis showed statistically significant differences in separation status between IBS and non-IBS children (P < 0.05). Multivariate analysis showed that in the model adjusted for demographic variables, separation from both parents demonstrated the strongest association with IBS (OR = 2.2, P < 0.0001) , and separation from father only (OR = 2.1, P < 0.0001) was significantly positively associated with IBS, but separation from mother only was not significantly associated with IBS (P ＞ 0.05), and the same trend was observed in the subgroup analysis of sex. The relationship between age and IBS risk in LBC was nonlinear, and the risk of IBS in LBC was highest at age 8 years. Conclusions: Separation from father only was significantly positively associated with IBS. And the relationship between age and IBS risk in LBC was nonlinear.
Keywords: Irritable Bowel Syndrome, Left-behind Children, Association, SEPARATION, risk factor
Received: 12 Mar 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Wei, Zhang, Xu, Tong, Yang, Xing, Dai, Wang and Qin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bin Qin, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
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