ORIGINAL RESEARCH article
Front. Public Health
Sec. Infectious Diseases: Epidemiology and Prevention
Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1593055
Global, regional and national burden of acute glomerulonephritis from1990 to 2021 and future trend prediction until 2036: a systematic analysis for the global burden of diseases study 2021
Provisionally accepted
- 1Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
- 2Department of Urology, China-Japan Friendship Hospital, Beijing 100029, China, Beijing, China
- 3China-Japan Friendship Hospital, Beijing 100029, China, Beijing, China
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To analyze the global, regional, and national burden of acute glomerulonephritis (AGN) from 1990 to 2021 and project its trends through 2036 using data from the Global Burden of Disease (GBD) study.Using the GBD 2021 dataset, we evaluated AGN burden in terms of incidence, mortality, and disability-adjusted life years (DALYs). Agestandardized rates (ASRs) were calculated, and trends were assessed using Estimated Annual Percentage Change (EAPC). Decomposition analysis quantified the contributions of population growth, aging, and epidemiological changes. Projections for AGN burden were modeled using the Auto-Regressive Integrated Moving Average (ARIMA) approach. Results: From 1990 to 2021, the global age-standardized incidence rate (ASIR) of AGN declined by 46.09%, and the age-standardized DALY rate decreased by 65.87%. Middle-SDI regions exhibited the highest burden, while high-SDI regions showed increasing mortality and DALY trends, potentially linked to autoimmune and systemic conditions. Decomposition analysis highlighted the role of epidemiological improvements, countered by the impacts of population growth and aging. Projections indicate a continued global decline, with a 43.81% reduction in ASIR and a 62.92% decline in the age-standardized DALY rate by 2036. Conclusion: Despite significant global progress, disparities persist, particularly in low-and middle-income regions. Targeted interventions, enhanced diagnostic capabilities, and strategies addressing socioeconomic determinants are essential to achieving equitable reductions in AGN burden. This study emphasizes the importance of global and regional strategies to improve AGN outcomes worldwide.
Keywords: Acute glomerulonephritis, Global Burden of Diseases, Incidence, Prevalence, Disability-adjusted life years
Received: 13 Mar 2025; Accepted: 26 Jun 2025.
Copyright: © 2025 Yu, Jiao, Chen, Zhang, Ma and Shen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Bo Yu, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
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