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ORIGINAL RESEARCH article

Front. Public Health

Sec. Infectious Diseases: Epidemiology and Prevention

Volume 13 - 2025 | doi: 10.3389/fpubh.2025.1596876

Predicting HIV Self-Testing Intentions Among Chinese College Students: A Dual-Model Analysis Integrating Health Belief Constructs and Machine Learning Prioritization

Provisionally accepted
Jing  LiJing Li1Jingfen  LuJingfen Lu2Liping  HeLiping He3Lin  HuLin Hu3Jiazhen  HeJiazhen He3Xianli  HuangXianli Huang3Yuchao  LiYuchao Li4Yan  JiangYan Jiang3*
  • 1Jinan University, Guangzhou, China
  • 2Guangzhou University of Chinese Medicine, Guangzhou, Guangdong Province, China
  • 3Xiangnan University, Chenzhou, Hunan Province, China
  • 4College of Humanities and Management, Hunan University of Chinese Medicine, Changsha, Anhui Province, China

The final, formatted version of the article will be published soon.

As college students emerge as a key HIV-vulnerable population in China, HIV selftesting (HIVST) presents a critical strategy for enhancing detection rates and enabling timely intervention. While observational studies have identified multifactorial influences on HIVST willingness, few investigations integrate behavioral theory with machine learning approaches among high-risk subgroups. This cross-sectional study employed stratified cluster sampling to recruit 1,015 undergraduates from Xiangnan College (July-August 2022), synthesizing the Health Belief Model (HBM) with random forest analytics to elucidate determinants of HIVST willingness. Among participants, 69.3% (n = 703) expressed willingness to adopt HIVST within the next 6 months. 15.0% reported sexual activity (n = 152), with 12.0% (n = 122) of sexually active participants demonstrating concurrent engagement in unprotected intercourse and HIV testing willingness. HBM-based logistic regression revealed that self-efficacy (OR = 1.64, 95% CI: 1.21-2.21) and cues to action (OR = 1.34, 1.04-1.75) were significant facilitators, contrasting with the inhibitory effects of perceived barriers (OR = 0.69, 0.55-0.86).Random forest modeling prioritized these psychological constructs (mean decrease Gini >2.5), identifying male students and arts majors as critical subpopulations requiring targeted intervention. Our dual-method analysis establishes that campus HIV control necessitates: 1) Gender-specific prevention programs addressing male students' elevated risk exposure; 2) HBM-informed education strengthening self-efficacy and environmental cues; 3) Structural interventions reducing testing barriers through discreet service delivery. This theoretical-empirical integration advances predictive understanding of HIVST behaviors, providing actionable insights for developing precision public health strategies in academic settings.

Keywords: health belief model, College student, HIV self-testing, high-risk behaviors, Random Forest modeling

Received: 21 Mar 2025; Accepted: 08 Jul 2025.

Copyright: © 2025 Li, Lu, He, Hu, He, Huang, Li and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Yan Jiang, Xiangnan University, Chenzhou, 423000, Hunan Province, China

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